Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12835-12847

  Sharp, Jared D ^a,b   Cruz, Jonathan W ^a   Raman, Sahadevan ^b,d   Inouye, Masayori ^c   Husson, Robert N ^b   Woychik, Nancy A ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL PROPERTIES; CELL-FREE SYSTEM; CELLULAR TARGETS; CLEAVAGE ACTIVITIES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDORIBONUCLEASE; GROWTH ARREST; M. TUBERCULOSIS; MODE OF ACTION; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN SYNTHESIS; RNA BINDING; RNA CLEAVAGE; STEADY-STATE LEVEL;

BACTERIA; BINDING ENERGY; ELECTROPHORETIC MOBILITY; ESCHERICHIA COLI; METABOLITES; RNA; TUBES (COMPONENTS);

TOXIC MATERIALS;

BACTERIAL TOXIN; MESSENGER RNA; RIBONUCLEASE; RNA; UNCLASSIFIED DRUG; VAPC TOXIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CELL FREE SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; GEL MOBILITY SHIFT ASSAY; GROWTH INHIBITION; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN RNA BINDING; PROTEIN SYNTHESIS INHIBITION; RNA CLEAVAGE; RNA SEQUENCE; STEADY STATE; TRANSLATION INHIBITION; TRANSLATION REGULATION;

ANTITOXINS; BACTERIAL TOXINS; DNA, BACTERIAL; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, BACTERIAL; RNA, MESSENGER; RNA-BINDING PROTEINS; VIRULENCE FACTORS;

ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 84859783727     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.340109     Document Type: Article

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