Abnormal epidermal barrier in the pathogenesis of psoriasis

Clinics in Dermatology

Volumn 30, Issue 3, 2012, Pages 323-328

  Wolf, Ronni ^a,b   Orion, Edith ^a,b   Ruocco, Eleonora ^c   Ruocco, Vincenzo ^c  

^a KAPLAN MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY   (Israel)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; ANTIMALARIAL AGENT; CERAMIDE; CHOLESTEROL; DNA; GEMFIBROZIL; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; SKIN LIPID;

ABNORMAL EPIDERMAL BARRIER; DISEASE PREDISPOSITION; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; DNA SYNTHESIS; EPIDERMIS HYPERPLASIA; GENE; GENE MAPPING; GENE MUTATION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HUMAN; IMMUNOPATHOLOGY; KERATINIZATION; KERATINOCYTE; LIPOGENESIS; NONHUMAN; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PSORIASIS; PSORIASIS SUSCEPTIBILITY LOCUS 4 GENE; SKIN DISEASE; SKIN STRUCTURE; STRATUM CORNEUM; T LYMPHOCYTE; TISSUE DIFFERENTIATION; TISSUE ENGINEERING;

CELL DIFFERENTIATION; CELL DIVISION; CORNIFIED ENVELOPE PROLINE-RICH PROTEINS; DNA REPLICATION; EPIDERMIS; GENE EXPRESSION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MUTATION; PERMEABILITY; PSORIASIS;

EID: 84859757141     PISSN: 0738081X     EISSN: 18791131     Source Type: Journal    
DOI: 10.1016/j.clindermatol.2011.08.022     Document Type: Note

References (47)

1. Nickoloff B.J., Wrone-Smith T., Bonish B., et al. Response of murine and normal human skin to injection of allogeneic blood-derived psoriatic immunocytes: detection of T cells expressing receptors typically present on natural killer cells, including CD94, CD158, and CD161. Arch Dermatol 1999, 135:546-552.
2. Nickoloff B.J., Schröder J.M., von den D.P., et al. Is psoriasis a T-cell disease?. Exp Dermatol 2000, 9:359-375.
3. Daikeler T., Gunaydin I., Einsele H., et al. Transmission of psoriatic arthritis by allogeneic bone marrow transplantation for chronic myelogenous leukaemia from an HLA-identical donor. Rheumatology (Oxford) 1999, 38:89-90.
4. Gardembas-Pain M., Ifrah N., Foussard C., et al. Psoriasis after allogeneic bone marrow transplantation. Arch Dermatol 1990, 126:1523.
5. Snowden J.A., Heaton D.C. Development of psoriasis after syngeneic bone marrow transplant from psoriatic donor: further evidence for adoptive autoimmunity. Br J Dermatol 1997, 137:130-132.
6. He Y.L., Lu X.J., Qiu J.Y., et al. Severe vulgaris psoriatic patients with acute myelogenous leukaemia and resolution after allogeneic bone marrow transplantation/peripheral blood stem cell transplantation. Chin Med J (Engl ) 2005, 118:861-865.
7. Kanamori H., Tanaka M., Kawaguchi H., et al. Resolution of psoriasis following allogeneic bone marrow transplantation for chronic myelogenous leukemia: case report and review of the literature. Am J Hematol 2002, 71:41-44.
8. Zenz R., Eferl R., Kenner L., et al. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 2005, 437:369-375.
9. Guinea-Viniegra J., Zenz R., Scheuch H., et al. TNFalpha shedding and epidermal inflammation are controlled by Jun proteins. Genes Dev 2009, 23:2663-2674.
10. Sano S., Chan K.S., Carbajal S., et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 2005, 11:43-49.
11. Williams M.L., Elias P.M. From basket weave to barrier. Unifying concepts for the pathogenesis of the disorders of cornification. Arch Dermatol 1993, 129:626-629.
12. Elias P.M. Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005, 125:183-200.
13. Eckert R.L., Sturniolo M.T., Broome A.M., et al. Transglutaminase function in epidermis. J Invest Dermatol 2005, 124:481-492.
14. Hitomi K. Transglutaminases in skin epidermis. Eur J Dermatol 2005, 15:313-319.
15. Schmuth M., Gruber R., Elias P.M., et al. Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders. Adv Dermatol 2007, 23:231-256.
16. Wolf R., Ruocco V. Triggered psoriasis. Adv Exp Med Biol 1999, 455:221-225.
17. Wolf R., Lo Schiavo A., Lombardi M.L., et al. The in vitro effect of hydroxychloroquine on skin morphology and transglutaminase. Int J Dermatol 1997, 36:704-707.
18. Wolf R., Lo Schiavo A., Lombardi M.L., et al. The in vitro effect of hydroxychloroquine on skin morphology in psoriasis. Int J Dermatol 1999, 38:154-157.
19. Harrison C.A., Layton C.M., Hau Z., et al. Transglutaminase inhibitors induce hyperproliferation and parakeratosis in tissue-engineered skin. Br J Dermatol 2007, 156:247-257.
20. Elias P.M., Williams M.L., Maloney M.E., et al. Stratum corneum lipids in disorders of cornification. Steroid sulfatase and cholesterol sulfate in normal desquamation and the pathogenesis of recessive X-linked ichthyosis. J Clin Invest 1984, 74:1414-1421.
21. Proksch E., Feingold K.R., Man M.Q., et al. Barrier function regulates epidermal DNA synthesis. J Clin Invest 1991, 87:1668-1673.
22. Grubauer G., Elias P.M., Feingold K.R. Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 1989, 30:323-333.
23. Feingold K.R., Man M.Q., Proksch E., et al. The lovastatin-treated rodent: a new model of barrier disruption and epidermal hyperplasia. J Invest Dermatol 1991, 96:201-209.
24. Wolf R., Lo Schiavo A., Russo A., et al. Effects of gemfibrozil on in vitro cultured normal human skin explants. Int J Dermatol 1999, 38:65-69.
25. Choi M.J., Maibach H.I. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol 2005, 6:215-223.
26. Wartewig S., Neubert R.H. Properties of ceramides and their impact on the stratum corneum structure: a review. Part 1:ceramides. Skin Pharmacol Physiol 2007, 20:220-229.
27. Jensen J.M., Proksch E. The skin's barrier. G Ital Dermatol Venereol 2009, 144:689-700.
28. Motta S., Monti M., Sesana S., et al. Ceramide composition of the psoriatic scale. Biochim Biophys Acta 1993, 1182:147-151.
29. Motta S., Sesana S., Monti M., et al. Interlamellar lipid differences between normal and psoriatic stratum corneum. Acta Derm Venereol Suppl (Stockh) 1994, 186:131-132.
30. Motta S., Monti M., Sesana S., et al. Abnormality of water barrier function in psoriasis. Role of ceramide fractions. Arch Dermatol 1994, 130:452-456.
31. Alessandrini F., Pfister S., Kremmer E., et al. Alterations of glucosylceramide-beta-glucosidase levels in the skin of patients with psoriasis vulgaris. J Invest Dermatol 2004, 123:1030-1036.
32. Hong K.K., Cho H.R., Ju W.C., et al. A study on altered expression of serine palmitoyltransferase and ceramidase in psoriatic skin lesion. J Korean Med Sci 2007, 22:862-867.
33. Alessandrini F., Stachowitz S., Ring J., et al. The level of prosaposin is decreased in the skin of patients with psoriasis vulgaris. J Invest Dermatol 2001, 116:394-400.
34. Cho Y., Lew B.L., Seong K., et al. An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis. J Korean Med Sci 2004, 19:859-863.
35. Travers J.B., Hamid Q.A., Norris D.A., et al. Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis. J Clin Invest 1999, 104:1181-1189.
36. Roberson E.D., Bowcock A.M. Psoriasis genetics: breaking the barrier. Trends Genet 2010, 26:415-423.
37. Strange A., Capon F., Spencer C.C., et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 2010, 42:985-990.
38. Stuart P.E., Nair R.P., Ellinghaus E., et al. Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet 2010, 42:1000-1004.
39. Sun L.D., Cheng H., Wang Z.X., et al. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet 2010, 42:1005-1009.
40. Mischke D., Korge B.P., Marenholz I., et al. Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex (' epidermal differentiation complex' ) on human chromosome 1q21. J Invest Dermatol 1996, 106:989-992.
41. Capon F., Novelli G., Semprini S., et al. Searching for psoriasis susceptibility genes in Italy:genome scan and evidence for a new locus on chromosome 1. J Invest Dermatol 1999, 112:32-35.
42. Capon F., Semprini S., Chimenti S., et al. Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21. J Invest Dermatol 2001, 116:728-730.
43. Liu Y., Helms C., Liao W., et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008, 4:e1000041.
44. de Cid R., Riveira-Munoz E., Zeeuwen P.L., et al. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet 2009, 41:211-215.
45. Zhang X.J., Huang W., Yang S., et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 2009, 41:205-210.
46. de Guzman S.C., Conlan S., Deming C.B., et al. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis. Hum Mol Genet 2010, 19:1453-1460.
47. Bergboer J.G., Zeeuwen P.L., Irvine A.D., et al. Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis. J Invest Dermatol 2010, 130:2057-2061.