In Vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-hydroxythalidomide in humanized TK-NOG mice

Chemical Research in Toxicology

Volumn 25, Issue 2, 2012, Pages 274-276

  Yamazaki, Hiroshi ^a   Suemizu, Hiroshi ^b   Shimizu, Makiko ^a   Igaya, Sho ^a   Shibata, Norio ^c   Nakamura, Masato ^b   Chowdhury, Goutam ^d   Guengerich, F Peter ^d  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^c NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYTHALIDOMIDE; CATECHOL; GANCICLOVIR; THALIDOMIDE; THALIDOMIDE DERIVATIVE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD LEVEL; CELL TRANSPLANTATION; CONTROLLED STUDY; GLUTATHIONE METABOLISM; IN VIVO STUDY; LIVER; MOUSE; NONHUMAN;

ANIMALS; CHIMERA; GLUTATHIONE; HEPATOCYTES; HUMANS; HYDROXYLATION; MICE; TERATOGENS; THALIDOMIDE;

MUS;

EID: 84859748529     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300009j     Document Type: Article

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