Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis

Medical Mycology

Volumn 50, Issue 4, 2012, Pages 421-426

  Schulz, Bettina ^a   Knobloch, Mathias ^a   Moran, Gary P ^b   Weber, Kai ^a   Ruhnke, Markus ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DUBLIN DENTAL UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Candida dubliniensis; Doxorubicin; Drug efflux pumps; Fluconazole susceptibility; Resistance

Indexed keywords

DOXORUBICIN; FLUCONAZOLE;

ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CANDIDA DUBLINIENSIS; CDCDR2 GENE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; FUNGAL GENE; FUNGUS ISOLATION; GENE EXPRESSION; NONHUMAN;

ANTIFUNGAL AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CANDIDA; DOXORUBICIN; FLUCONAZOLE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MICROBIAL SENSITIVITY TESTS;

CANDIDA DUBLINIENSIS;

EID: 84859744918     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2011.608730     Document Type: Article

References (21)

1. Viscoli C, Girmenia C, Marinus A, et al . Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC). Clin Infect Dis 1999; 28 : 1071-1079. (Pubitemid 29203541)
2. Vogel M, Hartmann T, Koberle M, et al . Rifampicin induces MDR1 expression in Candida albicans. J Antimicrob Chemother 2008; 61 : 541-547. (Pubitemid 351321125)
3. Kofl a G, Turner V, Schulz B, e t al . Doxorubicin induces drug effl ux pumps in Candida albicans. Med Mycol 2011; 49 : 132-142.
4. Karababa M, Coste AT, Rognon B, Bille J, Sanglard D. Comparison of gene expression profi les of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters. Antimicrob Agents Chemother 2004; 48 : 3064-3079. (Pubitemid 38989176)
5. de Micheli M, Bille J, Schueller C, Sanglard D. A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol Microbiol 2002; 43 : 1197-1214. (Pubitemid 34304537)
6. Sullivan DJ, Westerneng TJ, Haynes KA, Bennett DE, Coleman DC. Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIVinfected individuals. Microbiology 1995; 141 : 1507-1521.
7. Kibbler CC, Seaton S, Barnes RA, et al . Management and outcome of bloodstream infections due to Candida species in England and Wales. J Hosp Infect 2003; 54 : 18-24. (Pubitemid 38002021)
8. Manfredi M, McCullough MJ, Al-Karaawi ZM, Hurel SJ, Porter SR. The isolation, identifi cation and molecular analysis of Candida spp. isolated from the oral cavities of patients with diabetes mellitus. Oral Microbiol Immunol 2002; 17 : 181-185. (Pubitemid 34580756)
9. Peltroche-Llacsahuanga H, Dohmen H, Haase G. Recovery of C andida dubliniensis from sputum of cystic fi brosis patients. Mycoses 2002; 45 : 15-18. (Pubitemid 34175498)
10. Davies AN, Brailsford S, Broadley K, Beighton D. Oral yeast carriage in patients with advanced cancer. Oral Microbiol Immunol 2002; 17 : 79-84.
11. Dahiya MC, Redding SW, Dahiya RS, e t al . Oropharyngeal candidiasis caused by non- albicans yeast in patients receiving external beam radiotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2003; 57 : 79-83. (Pubitemid 36959741)
12. Dougherty PF, Yotter DW, Matthews TR. Microdilution transfer plate technique for determining in vitro synergy of antimicrobial agents. Antimicrob Agents Chemother 1977; 11 : 225-228. (Pubitemid 8042471)
13. Odds FC. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother 2003; 52 : 1. (Pubitemid 36850074)
14. Moran G, Sullivan D, Morschha user J, Coleman D. The Candida dubliniensis CdCDR1 gene is not essential for fl uconazole resistance. Antimicrob Agents Chemother 2002; 46 : 2829-2841.
15. Perea S, Lopez-Ribot JL, Wickes BL, e t al . Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother 2002; 46 : 1695-1703. (Pubitemid 34535185)
16. Pinjon E, Moran GP, Jackson CJ, et al . Molecular mechanisms of itraconazole resistance in Candida dubliniensis . Antimicrob Agents Chemother 2003; 47 : 2424-2437. (Pubitemid 36919440)
17. Moran GP, Sanglard D, Donnelly SM, et al . Identifi cation and expression of multidrug transporters responsible for fl uconazole resistance in Candida dubliniensis . Antimicrob Agents Chemother 1998; 42 : 1819-1830. (Pubitemid 28311586)
18. Pinjon E, Jackson CJ, Kelly SL, et al. Reduced azole susceptibility in genotype 3 Candida dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression. Antimicrob Agents Chemother 2005; 49 : 1312-1318. (Pubitemid 40463353)
19. Coleman DC, Moran GP, McManus BA, Sullivan DJ. Mechanisms of antifungal drug resistance in Candida dubliniensis. Future Microbiol 2010; 5 : 935-949.
20. Sanger Institute. Candida dubliniensis sequencing. www.sanger. ac.uk/sequencing/Candida/dubliniensis/.
21. Krishnamurthy S, Gupta V, Snehlata P, Prasad R. Characterisation of human steroid hormone transport mediated by Cdr1p, a multidrug transporter of Candida albicans , belonging to the ATP binding cassette super family. FEMS Microbiol Lett 1998; 158 : 69-74. (Pubitemid 28088104)