Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites

Reproductive Toxicology

Volumn 33, Issue 3, 2012, Pages 353-360

  Paulose, Tessie ^a   Hannon, Patrick R ^a   Peretz, Jackye ^a   Craig, Zelieann R ^a   Flaws, Jodi A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Antral follicles; Apoptosis; Atresia; Estrogenic; Metabolites; Methoxychlor; Reproduction

Indexed keywords

CASPASE 3; CASPASE 7; DRUG METABOLITE; ESTROGEN RECEPTOR ALPHA; METHOXYCHLOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GENOTYPE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY FOLLICLE; OVARY FOLLICLE ATRESIA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 3; CASPASE 7; ESTROGEN RECEPTOR ALPHA; FEMALE; FOLLICULAR ATRESIA; GENE EXPRESSION; INSECTICIDES; METHOXYCHLOR; MICE; MICE, TRANSGENIC; OVARIAN FOLLICLE; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2;

MUS;

EID: 84859741133     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.01.007     Document Type: Article

References (35)

1. Hirshfield A.N. Development of follicles in the mammalian ovary. Int Rev Cytol 1991, 124:43-101.
2. Richards J.S., Jahnsen T., Hedin L., Lifka J., Ratoosh S., Durica J.M., et al. Ovarian follicular development: from physiology to molecular biology. Recent Prog Horm Res 1987, 43:231-274.
3. McGee E.A., Hsueh A.J. Initial and cyclic recruitment of ovarian follicles. Endocr Rev 2000, 21:200-214.
4. Tilly J.L. The molecular basis of ovarian cell death during germ cell attrition, follicular atresia, and luteolysis. Front Biosci 1996, 1:d1-d11.
5. Zuckerman S. The number of oocytes in the mature ovary. Recent Prog Horm 1951, 6:63-109.
6. Telfer E.E., Gosden R.G., Byskov A.G., Spears N., Albertini D., Andersen C.Y., et al. On regenerating the ovary and generating controversy. Cell 2005, 122:821-822.
7. Byskov A.G., Faddy M.J., Lemmen J.G., Andersen C.Y. Eggs forever. Differentiation 2005, 73:438-446.
8. Gupta R.K., Miller K.P., Babus J.K., Flaws J.A. Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway. Toxicol Sci 2006, 93:382-389.
9. Borgeest C., Symonds D., Mayer L.P., Hoyer P.B., Flaws J.A. Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. Toxicol Sci 2002, 68:473-478.
10. Miller K.P., Gupta R.K., Greenfeld C., Babus J., Flaws J.A. Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways. Toxicol Sci 2005, 88:213-221.
11. Borgeest C., Miller K.P., Gupta R., Greenfeld C., Hruska K.S., Hoyer P., et al. Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol. Biol Reprod 2004, 70:1828-1835.
12. Swartz W.J., Eroschenko V.P. Neonatal exposure to technical methoxychlor alters pregnancy outcome in female mice. Reprod Toxicol 1998, 6:565-573.
13. Gast G.C., Grobbee D.E., Pop V.J., Keyzer J.J., Wijnands-van Gent C.J., Samsioe G.N., et al. Menopausal complaints are associated with cardiovascular risk factors. Hypertension 2008, 6:1492-1498.
14. Bagur A.C., Mautzlen C.A. Risk for developing osteoporosis in untreated premature menopause. Calcified Tissue Int 1992, 51:4-7.
15. Cummings A.M. Methoxychlor as a model for environmental estrogens. Crit Rev Toxicol 1997, 27:367-379.
16. Gray L.E, Ostby J., Cooper R.L., Kelce W.R. The estrogenic pesticide and antiandrogenic pesticide methoxychlor alters the reproductive tract and behavior without affecting pituitary size or LH and prolactin secretion on male rats. Toxicol Ind Health 1999, 15:37-47.
17. Bulger W.H., Muccitelli R.M., Kupfer D. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem Pharmacol 1978, 27:2417-2423.
18. Miller K.P., Gupta R.K., Flaws J.A. Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. Toxicol Sci 2006, 93:180-188.
19. Newbold R.R., Jefferson W.N., Padilla-Banks E., Haseman J. Developmental exposure to diethylstilbesterol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects. Reprod Toxicol 2004, 18:399-406.
20. Patisaul H.B., Whitten P.L., Young L.J. Regulation of estrogen receptor beta mRNA in the brain: opposite effects of 17beta-estradiol and the phytoestrogen, coumestrol. Mol Brain Res 1999, 67:165-171.
21. Tanaka Y., Sasaki M., Kaneuchi M., Fujimoto S., Dahiya R. Estrogen receptor alpha polymorphisms and renal cell carcinoma - a possible risk. Mol Cell Endocrinol 2003, 202:109-116.
22. Gaido K.W., Maness S.C., McDonnell D.P., Dehal S.S., Kupfer D., Safe S. Interaction of methoxychlor and related compounds with estrogen receptor a and b, and androgen receptor: structure-activity studies. Mol Pharmacol 2000, 58:852-858.
23. Waters K.M., Safe S., Gaido K.W. Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol Sci 2001, 63:47-56.
24. Paulose T., Hernandez-Ochoa I., Basavarajappa M.S., Peretz J., Flaws J.A. Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites. Toxicol Sci 2011, 120:447-459.
25. Tomic D., Frech M.S., Babus J.K., Symonds D., Furth P.A., Koos R.D., et al. Effects of ERalpha overexpression on female reproduction in mice. Reprod Toxicol 2007, 23:317-325.
26. Boone D.L., Tsang B.K. Capase-3 in the rat ovary: localization and possible role in follicular atresia and luteal regression. Biol Reprod 1998, 58:1533-1539.
27. Fenwick M.A., Hurst P.R. Immunohistochemical localization of active caspase-3 in the mouse ovary: growth and atresia of small follicles. Reproduction 2002, 124:659-665.
28. Hirshfield A.N. Overview of ovarian follicular development: considerations of the toxicologist. Environ Mol Mutagen 1997, 29:10-15.
29. Chang E.C., Charn T.H., Park S.H., Helferich W.G., Komm B., Katzenellenbogen J.A., et al. Estrogen receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol 2008, 22:1032-1033.
30. Hall J.M., McDonnell D.P. The estrogen receptor b-isoform (ERb) of the human estrogen receptor modulates ERa transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 1999, 140:5566-5578.
31. Tomic D., Frech M.S., Babus J.K., Gupta R.K., Furth P.A., Flaws J.A. Methoxychlor induces atresia of antral follicles in ERalpha-overexpressing mice. Toxicol Sci 2006, 93:196-204.
32. Gupta R.K., Schuh R.A., Fiskum G., Flaws J.A. Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. Toxicol Appl Pharmacol 2006, 216:436-445.
33. Johnson A.L., Bridgham J.T. Caspase-mediated apoptosis in the vertebrate ovary. Reproduction 2002, 124:19-27.
34. 2-M arrest: evidence of commitment to apoptosis rather than mitotic cell death. Clin Can Res 2000, 6:3756-3765.
35. 2+-dependent endonuclease. Biochem Pharmacol 2002, 63:225-236.