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Volumn 93, Issue 1, 2006, Pages 196-204

Methoxychlor induces atresia of antral follicles in ERα-overexpressing mice

Author keywords

ER ; Follicle atresia; Methoxychlor; Mouse model

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; FOLLITROPIN; LUCIFERASE; METHOXYCHLOR; SESAME SEED OIL;

EID: 33747878620     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl040     Document Type: Article
Times cited : (23)

References (51)
  • 1
    • 20444482544 scopus 로고    scopus 로고
    • Toxicological Profile for Methoxychlor
    • Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Department of Health and Human Services Public Health Service, ATSDR, Atlanta, GA
    • Agency for Toxic Substances and Disease Registry (ATSDR) (2002). Toxicological Profile for Methoxychlor. pp. 161. U.S. Department of Health and Human Services Public Health Service, ATSDR, Atlanta, GA.
    • (2002) , pp. 161
  • 2
    • 0030198407 scopus 로고    scopus 로고
    • Influence of organochlorine pesticides on development of mouse embryos in vitro
    • Alm, H., Tiemann, U., and Torner, H. (1996). Influence of organochlorine pesticides on development of mouse embryos in vitro. Reprod. Toxicol. 10, 321-326.
    • (1996) Reprod. Toxicol. , vol.10 , pp. 321-326
    • Alm, H.1    Tiemann, U.2    Torner, H.3
  • 3
    • 0033934258 scopus 로고    scopus 로고
    • Organochlorine pesticides concentration in the drinking water from regions of extensive agriculture in Poland
    • Badach, H., Nazimek, T., Kaminski, R., and Turski, W. A. (2000). Organochlorine pesticides concentration in the drinking water from regions of extensive agriculture in Poland. Ann. Agric. Environ. Med. 7, 25-28.
    • (2000) Ann. Agric. Environ. Med. , vol.7 , pp. 25-28
    • Badach, H.1    Nazimek, T.2    Kaminski, R.3    Turski, W.A.4
  • 4
    • 0027423114 scopus 로고
    • Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis
    • Billig, H., Furuta, I., and Hsueh, A. J. (1993). Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology 133, 2204-2212.
    • (1993) Endocrinology , vol.133 , pp. 2204-2212
    • Billig, H.1    Furuta, I.2    Hsueh, A.J.3
  • 5
    • 2642548115 scopus 로고    scopus 로고
    • Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol
    • Borgeest, C., Miller, K. P., Gupta, R., Greenfeld, C., Hruska, K. S., Hoyer, P., and Flaws, J. A. (2004). Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol. Biol. Reprod. 70, 1828-1835.
    • (2004) Biol. Reprod. , vol.70 , pp. 1828-1835
    • Borgeest, C.1    Miller, K.P.2    Gupta, R.3    Greenfeld, C.4    Hruska, K.S.5    Hoyer, P.6    Flaws, J.A.7
  • 6
    • 0036667372 scopus 로고    scopus 로고
    • Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse
    • Borgeest, C., Symonds, D., Mayer, L. P., Hoyer, P. B., and Flaws, J. A. (2002). Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. Toxicol. Sci. 68, 473-478.
    • (2002) Toxicol. Sci. , vol.68 , pp. 473-478
    • Borgeest, C.1    Symonds, D.2    Mayer, L.P.3    Hoyer, P.B.4    Flaws, J.A.5
  • 7
    • 0036855363 scopus 로고    scopus 로고
    • Estrogen actions in the ovary revisited
    • Britt, K. L., and Findlay, J. K. (2002). Estrogen actions in the ovary revisited. J. Endocrinol. 175, 269-276.
    • (2002) J. Endocrinol. , vol.175 , pp. 269-276
    • Britt, K.L.1    Findlay, J.K.2
  • 8
    • 0018078757 scopus 로고
    • Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation
    • Bulger, W. H., Muccitelli, R. M., and Kupfer, D. (1978). Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol. 27, 2417-2423.
    • (1978) Biochem. Pharmacol. , vol.27 , pp. 2417-2423
    • Bulger, W.H.1    Muccitelli, R.M.2    Kupfer, D.3
  • 10
    • 0029918632 scopus 로고    scopus 로고
    • Hormonal regulation of apoptosis in early antral follicles: Follicle-stimulating hormone as a major survival factor
    • Chun, S. Y., Eisenhauer, K. M., Minami, S., Billig, H., Perlas, E., and Hsueh, A. J. (1996). Hormonal regulation of apoptosis in early antral follicles: Follicle-stimulating hormone as a major survival factor. Endocrinology 137, 1447-1456.
    • (1996) Endocrinology , vol.137 , pp. 1447-1456
    • Chun, S.Y.1    Eisenhauer, K.M.2    Minami, S.3    Billig, H.4    Perlas, E.5    Hsueh, A.J.6
  • 11
    • 0002752419 scopus 로고
    • Monitoring of estrus cyclicity in the laboratory rodent by vaginal lavage
    • In (R. E. Chapin and J. Heindel, Eds.), Academic Press, Orlando
    • Cooper, R. L., Goldman, J., and Vandenbergh, J. G. (1993). Monitoring of estrus cyclicity in the laboratory rodent by vaginal lavage. In Methods in Toxicology (R. E. Chapin and J. Heindel, Eds.), Vol. 3 B, pp. 45-56. Academic Press, Orlando.
    • (1993) Methods in Toxicology , vol.3 B , pp. 45-56
    • Cooper, R.L.1    Goldman, J.2    Vandenbergh, J.G.3
  • 12
    • 0031839778 scopus 로고    scopus 로고
    • Exploring the role of sex steroids through studies of receptor deficient mice
    • Couse, J. F., and Korach, K. S. (1998). Exploring the role of sex steroids through studies of receptor deficient mice. J. Mol. Med. 76, 497-511.
    • (1998) J. Mol. Med. , vol.76 , pp. 497-511
    • Couse, J.F.1    Korach, K.S.2
  • 13
    • 0024573314 scopus 로고
    • Antifertility effect of methoxychlor in female rats: Dose- and time-dependent blockade of pregnancy
    • Cummings, A. M., and Gray, L. E., Jr. (1989). Antifertility effect of methoxychlor in female rats: Dose- and time-dependent blockade of pregnancy. Toxicol. Appl. Pharmacol. 97, 454-462.
    • (1989) Toxicol. Appl. Pharmacol , vol.97 , pp. 454-462
    • Cummings, A.M.1    Gray Jr., L.E.2
  • 14
    • 0028535093 scopus 로고
    • Mechanisms of the stimulation of rat uterine peroxidase activity by methoxyclor
    • Cummings, A. M., and Metcalf, J. L. (1994). Mechanisms of the stimulation of rat uterine peroxidase activity by methoxyclor. Reprod. Toxicol. 8, 477-486.
    • (1994) Reprod. Toxicol. , vol.8 , pp. 477-486
    • Cummings, A.M.1    Metcalf, J.L.2
  • 15
    • 0031792162 scopus 로고    scopus 로고
    • The effects of environmental hormones on reproduction
    • Danzo, B. J. (1998). The effects of environmental hormones on reproduction. Cell. Mol. Life Sci. 54, 1249-1264.
    • (1998) Cell. Mol. Life Sci. , vol.54 , pp. 1249-1264
    • Danzo, B.J.1
  • 16
    • 0030197562 scopus 로고    scopus 로고
    • Estradiol or methoxychlor stimulates estrogen receptor (ER) expression in uteri
    • Eroschenko, V. P., Rourke, A. W., and Sims, W. F. (1996). Estradiol or methoxychlor stimulates estrogen receptor (ER) expression in uteri. Reprod. Toxicol. 10, 265-271.
    • (1996) Reprod. Toxicol. , vol.10 , pp. 265-271
    • Eroschenko, V.P.1    Rourke, A.W.2    Sims, W.F.3
  • 18
    • 0035076648 scopus 로고    scopus 로고
    • Effect of Bcl-2 on the primordial follicle endowment in the mouse ovary
    • Flaws, J. A., Hirshfield, A. N., Hewitt, J. A., Babus, J. K., and Furth, P. A. (2001). Effect of Bcl-2 on the primordial follicle endowment in the mouse ovary. Biol. Reprod. 64, 1153-1159.
    • (2001) Biol. Reprod. , vol.64 , pp. 1153-1159
    • Flaws, J.A.1    Hirshfield, A.N.2    Hewitt, J.A.3    Babus, J.K.4    Furth, P.A.5
  • 19
    • 0003890934 scopus 로고
    • Pesticide Residue Levels in Foods in the USA, July 1, 1969-June 30, 1976
    • Food and Drug Administration and Association of Official Analytical Chemists, Washington, D.C
    • Duggan, R. E., Corneliussen, P. E., Duggan, M. B., McMahon, B. M., and Martin, R. J. (1983). Pesticide Residue Levels in Foods in the USA, July 1, 1969-June 30, 1976. Food and Drug Administration and Association of Official Analytical Chemists, Washington, D.C.
    • (1983)
    • Duggan, R.E.1    Corneliussen, P.E.2    Duggan, M.B.3    McMahon, B.M.4    Martin, R.J.5
  • 20
    • 13444272959 scopus 로고    scopus 로고
    • Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ
    • Frech, M. S., Halama, E. D., Tilli, M. T., Singh, B., Gunther, E. J., Chodosh, L. A., Flaws, J. A., and Furth, P. A. (2005). Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ. Cancer Res. 65, 1-5.
    • (2005) Cancer Res. , vol.65 , pp. 1-5
    • Frech, M.S.1    Halama, E.D.2    Tilli, M.T.3    Singh, B.4    Gunther, E.J.5    Chodosh, L.A.6    Flaws, J.A.7    Furth, P.A.8
  • 22
    • 0033304499 scopus 로고    scopus 로고
    • Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors α and β
    • Gaido, K. W., Leonard, L. S., Maness, S. C., Hall, J. M., McDonnell, D. P., Saville, B., and Safe, S. (1999). Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors α and β. Endocrinology 140, 5746-5753.
    • (1999) Endocrinology , vol.140 , pp. 5746-5753
    • Gaido, K.W.1    Leonard, L.S.2    Maness, S.C.3    Hall, J.M.4    McDonnell, D.P.5    Saville, B.6    Safe, S.7
  • 23
    • 0033304492 scopus 로고    scopus 로고
    • Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER)α and non-ERβ mechanism
    • Ghosh, D., Taylor, J. A., Green, J. A., and Lubahn, D. B. (1999). Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER)α and non-ERβ mechanism. Endocrinology 140, 3526-3533.
    • (1999) Endocrinology , vol.140 , pp. 3526-3533
    • Ghosh, D.1    Taylor, J.A.2    Green, J.A.3    Lubahn, D.B.4
  • 25
    • 0031563523 scopus 로고    scopus 로고
    • Effect of methoxychlor on implantation and embryo development in the mouse
    • Hall, D. L., Payne, L. A., Putnam, J. M., and Huet-Hudson, Y.M. (1997). Effect of methoxychlor on implantation and embryo development in the mouse. Reprod. Toxicol. 11, 703-708.
    • (1997) Reprod. Toxicol. , vol.11 , pp. 703-708
    • Hall, D.L.1    Payne, L.A.2    Putnam, J.M.3    Huet-Hudson, Y.M.4
  • 26
    • 0034115525 scopus 로고    scopus 로고
    • Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro
    • Hodges, L. C., Bergerson, J. S., Hunter, D. S., and Walker, C. L. (2000). Estrogenic effects of organochlorine pesticides on uterine leiomyoma cells in vitro. Toxicol. Sci. 54, 355-364.
    • (2000) Toxicol. Sci. , vol.54 , pp. 355-364
    • Hodges, L.C.1    Bergerson, J.S.2    Hunter, D.S.3    Walker, C.L.4
  • 28
    • 0028586850 scopus 로고
    • Ovarian follicle atresia: A hormonally controlled apoptotic process
    • Hsueh, A. J., Billig, H., and Tsafriri, A. (1994). Ovarian follicle atresia: A hormonally controlled apoptotic process. Endocr. Rev. 15, 707-724.
    • (1994) Endocr. Rev. , vol.15 , pp. 707-724
    • Hsueh, A.J.1    Billig, H.2    Tsafriri, A.3
  • 29
    • 0023267974 scopus 로고
    • Metabolic activation of pesticides with proestrogenic activity
    • Kupfer, D., and Bulger, W. H. (1987). Metabolic activation of pesticides with proestrogenic activity. Fed. Proc. 46, 1864-1869.
    • (1987) Fed. Proc. , vol.46 , pp. 1864-1869
    • Kupfer, D.1    Bulger, W.H.2
  • 30
    • 0025013048 scopus 로고
    • Construction of cell lines that express high levels of the human estrogen receptor and are killed by estrogens
    • Kushner, P. J., Hort, E., Shine, J., Baxter, J. D., and Greene, G. L. (1990). Construction of cell lines that express high levels of the human estrogen receptor and are killed by estrogens. Mol. Endocrinol. 4, 1465-1473.
    • (1990) Mol. Endocrinol. , vol.4 , pp. 1465-1473
    • Kushner, P.J.1    Hort, E.2    Shine, J.3    Baxter, J.D.4    Greene, G.L.5
  • 31
    • 0037254999 scopus 로고    scopus 로고
    • Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray
    • Larkin, P., Folmar, L. C., Hemmer, M. J., Poston, A. J., and Denslow, N. D. (2003). Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray. EHP Toxicogenomics 111, 29-36.
    • (2003) EHP Toxicogenomics , vol.111 , pp. 29-36
    • Larkin, P.1    Folmar, L.C.2    Hemmer, M.J.3    Poston, A.J.4    Denslow, N.D.5
  • 32
    • 0030250390 scopus 로고    scopus 로고
    • Methoxychlor mimics the action of 17 beta-estradiol on induction of uterine epidermal growth factor receptors in immature female rats
    • Metcalf, J. L., Laws, S. C., and Cummings, A. M. (1996). Methoxychlor mimics the action of 17 beta-estradiol on induction of uterine epidermal growth factor receptors in immature female rats. Reprod. Toxicol. 10, 393-399.
    • (1996) Reprod. Toxicol. , vol.10 , pp. 393-399
    • Metcalf, J.L.1    Laws, S.C.2    Cummings, A.M.3
  • 33
    • 27644502785 scopus 로고    scopus 로고
    • Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways
    • Miller, K. P., Gupta, R. K., Greenfeld, C. R., Babus, J. K., and Flaws, J. A. (2005). Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways. Toxicol. Sci. 88, 213-221.
    • (2005) Toxicol. Sci. , vol.88 , pp. 213-221
    • Miller, K.P.1    Gupta, R.K.2    Greenfeld, C.R.3    Babus, J.K.4    Flaws, J.A.5
  • 34
    • 33747884778 scopus 로고    scopus 로고
    • Methoxychlor metabolites may cause ovarian toxicity through estrogen regulated pathways
    • June 7, 2006; EPub ahead of print
    • Miller, K. P., Gupta, R. K., and Flaws, J. A. (2006). Methoxychlor metabolites may cause ovarian toxicity through estrogen regulated pathways. Toxicol. Sci. June 7, 2006; EPub ahead of print.
    • (2006) Toxicol. Sci.
    • Miller, K.P.1    Gupta, R.K.2    Flaws, J.A.3
  • 36
    • 0034767419 scopus 로고    scopus 로고
    • A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'enhanced OECD test guideline 407′ for screening endocrine-disrupting chemicals
    • Okazaki, K., Okazaki, S., Nishimura, S., Nakamura, H., Kitamura, Y., Hatayama, K., Nakamura, A., Tsuda, T., Katsumata, T., Nishikawa, A., et al. (2001). A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'enhanced OECD test guideline 407′ for screening endocrine-disrupting chemicals. Arch. Toxicol. 75, 513-521.
    • (2001) Arch. Toxicol. , vol.75 , pp. 513-521
    • Okazaki, K.1    Okazaki, S.2    Nishimura, S.3    Nakamura, H.4    Kitamura, Y.5    Hatayama, K.6    Nakamura, A.7    Tsuda, T.8    Katsumata, T.9    Nishikawa, A.10
  • 37
    • 0031171770 scopus 로고    scopus 로고
    • Effects of testosterone and oestradiol on [3H]-thymidine incorporation by porcine granulosa and theca cells
    • Ranson, E. J., Picton, H. M., and Hunter, M. G. (1997). Effects of testosterone and oestradiol on [3H]-thymidine incorporation by porcine granulosa and theca cells. Anim. Reprod. Sci. 47, 229-236.
    • (1997) Anim. Reprod. Sci. , vol.47 , pp. 229-236
    • Ranson, E.J.1    Picton, H.M.2    Hunter, M.G.3
  • 38
    • 0023155647 scopus 로고
    • Evidence for widespread atresia in the hypophysectomized estrogen-treated rat
    • Sadrkhanloo, R., Hofeditz, C., and Erickson, G. F. (1987). Evidence for widespread atresia in the hypophysectomized estrogen-treated rat. Endocrinology 120, 146-155.
    • (1987) Endocrinology , vol.120 , pp. 146-155
    • Sadrkhanloo, R.1    Hofeditz, C.2    Erickson, G.F.3
  • 39
    • 0029021083 scopus 로고
    • A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice
    • Shockett, P., Difilippantonio, M., Hellman, N., and Schatz, D. G. (1995). A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc. Natl. Acad. Sci. 92, 6522-6526.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 6522-6526
    • Shockett, P.1    Difilippantonio, M.2    Hellman, N.3    Schatz, D.G.4
  • 40
    • 0026300098 scopus 로고
    • Comparison of random and serial sections in assessment of ovarian toxicity
    • Smith, B. J., Plowchak, D. R., Sipes, I. G., and Mattison, D. R. (1991). Comparison of random and serial sections in assessment of ovarian toxicity. Reprod. Toxicol. 5, 379-383.
    • (1991) Reprod. Toxicol. , vol.5 , pp. 379-383
    • Smith, B.J.1    Plowchak, D.R.2    Sipes, I.G.3    Mattison, D.R.4
  • 41
    • 0027015074 scopus 로고
    • Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnancies
    • Swartz, W. J., and Corkern, M. (1992). Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnancies. Reprod. Toxicol. 6, 431-437.
    • (1992) Reprod. Toxicol. , vol.6 , pp. 431-437
    • Swartz, W.J.1    Corkern, M.2
  • 42
    • 0032215928 scopus 로고    scopus 로고
    • Neonatal exposure to technical methoxychlor alters pregnancy outcome in female mice
    • Swartz, W. J., and Eroschenko, V. P. (1998). Neonatal exposure to technical methoxychlor alters pregnancy outcome in female mice. Reprod. Toxicol. 12, 565-573.
    • (1998) Reprod. Toxicol. , vol.12 , pp. 565-573
    • Swartz, W.J.1    Eroschenko, V.P.2
  • 43
    • 31144434401 scopus 로고    scopus 로고
    • Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium
    • Symonds, D. A., Miller, K. P., Tomic, D., and Flaws, J. A. (2006). Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium. Toxicol. Sci. 89, 510-514.
    • (2006) Toxicol. Sci. , vol.89 , pp. 510-514
    • Symonds, D.A.1    Miller, K.P.2    Tomic, D.3    Flaws, J.A.4
  • 44
    • 2642578547 scopus 로고    scopus 로고
    • Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals
    • Terasaka, S., Aita, Y., Inoue, A., Hayashi, S., Nishigaki, M., Aoyagi, K., Sasaki, H., Wada-Kiyama, Y., Sakuma, Y., Akaba, S., et al. (2004). Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ. Health Perspect. 112, 773-781.
    • (2004) Environ. Health Perspect. , vol.112 , pp. 773-781
    • Terasaka, S.1    Aita, Y.2    Inoue, A.3    Hayashi, S.4    Nishigaki, M.5    Aoyagi, K.6    Sasaki, H.7    Wada-Kiyama, Y.8    Sakuma, Y.9    Akaba, S.10
  • 45
    • 0142182119 scopus 로고    scopus 로고
    • Introduction to estrogen receptor-α into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma
    • Tilli, M. T., Frech, M. S., Steed, M. E., Hruska, K. S., Johnson, M. D., Flaws, J. A., and Furth, P. A. (2003). Introduction to estrogen receptor-α into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma. Am. J. Pathol. 163, 1713-1719.
    • (2003) Am. J. Pathol. , vol.163 , pp. 1713-1719
    • Tilli, M.T.1    Frech, M.S.2    Steed, M.E.3    Hruska, K.S.4    Johnson, M.D.5    Flaws, J.A.6    Furth, P.A.7
  • 48
    • 33747888742 scopus 로고    scopus 로고
    • Consumer fact sheet on methoxychlor
    • U.S. Environmental Protection Agency (U.S. EPA) EPA Office of Water, 4-12-2001. Available at:, Accessed August 22, 2001
    • U.S. Environmental Protection Agency (U.S. EPA) (2001). Consumer fact sheet on methoxychlor. EPA Office of Water, 4-12-2001. Available at: http://www.epa.gov/safewater/dwh/c-soc/methoxyc.html. Accessed August 22, 2001.
    • (2001)
  • 49
    • 27644477614 scopus 로고
    • The fate of methoxychlor applied by helicopter for smaller European elm bark beetle control
    • Wallner, W. E., Leeling, N. C., and Zabik, M. J. (1969). The fate of methoxychlor applied by helicopter for smaller European elm bark beetle control. J. Econ. Entomol. 62, 1039-1042.
    • (1969) J. Econ. Entomol. , vol.62 , pp. 1039-1042
    • Wallner, W.E.1    Leeling, N.C.2    Zabik, M.J.3
  • 50
    • 0034871380 scopus 로고    scopus 로고
    • Differential gene expression in response to methoxychlor and estradiol through ERα, ERβ, and AR in reproductive tissues of female mice
    • Waters, K. M., Safe, S., and Gaido, K. W. (2001). Differential gene expression in response to methoxychlor and estradiol through ERα, ERβ, and AR in reproductive tissues of female mice. Toxicol. Sci. 63, 47-56.
    • (2001) Toxicol. Sci. , vol.63 , pp. 47-56
    • Waters, K.M.1    Safe, S.2    Gaido, K.W.3


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