Altered methylation of the DNA repair gene MGMT is associated with neural tube defects

Journal of Molecular Neuroscience

Volumn 47, Issue 1, 2012, Pages 42-51

  Tran, Susanna ^a   Wang, Li ^b   Le, Jing ^b   Guan, Jing ^b   Wu, Lihua ^b   Zou, Jizhen ^b   Wang, Zhen ^b   Wang, Jianhua ^b   Wang, Fang ^b   Chen, Xiaoli ^b   Cai, Lingling ^b   Lu, Xiaolin ^b   Zhao, Huizhi ^b   Guo, Jin ^b   Bao, Yihua ^b   Zheng, Xiaoying ^c   Zhang, Ting ^b  

^a MATTEL CHILDREN S HOSPITAL   (United States)

^b CAPITAL INSTITUTE OF PEDIATRICS   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Anencephaly; Cephalocele; DNA methylation; DNA repair gene; Neural tube defects; O6 methylguanine DNA methyltransferase (MGMT); Spina bifida

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN MSH6; PROTEIN P53; PROTEIN P73;

ARTICLE; BRAIN MALFORMATION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPAIR; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; HUMAN; HUMAN TISSUE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NEURAL TUBE DEFECT; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE;

DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; EMBRYONIC DEVELOPMENT; FEMALE; FETUS; HUMANS; MALE; NEURAL TUBE DEFECTS; TUMOR SUPPRESSOR PROTEINS;

EID: 84859706632     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9676-2     Document Type: Article

References (32)

1. Afman L, Blom H, Drittiji M, Brouns M, van Straaten HWM (2005) Inhibition of transmethylation disturbs neurulation in chick embryos. Brain Res Dev Brain Res 158:59-65 (Pubitemid 41116632)
2. Bearzatto A, Szadkowski M, Macpherson P, Jiricny J, Karran P (2000) Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. Cancer Res 60:3262-3270 (Pubitemid 30407926)
3. Blom HJ, Shaw GM, den Heijer M, Finnell RH (2006) Neural tube defects and folate: case far from closed. Nat Rev Neurosci 7:724-731 (Pubitemid 44267496)
4. Caberet A, Loget P, Loeuillet L, Odent S, Poulain P (2007) Embryology of neural tube defects: information provided by associated malformations. Prenat Diagn 27:738-742 (Pubitemid 47242404)
5. Cairns-Smith S, Karran P (1992) Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in mex2 human cells. Cancer Res 52:5257-5263
6. Cankovic M, Mikkelsen T, Rosenblum M, Zarbo R (2007) A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue. Lab Invest 87:392-397 (Pubitemid 46474563)
7. Chen X, Guo J, Lei Y, Zou J, Lu X, Bao Y, Wu L, Wu J, Zheng X, Shen Y, Wu B, Zhang T (2010) Global DNA hypomethylation is associated with NTD-affected pregnancy: a case-control study. Birth Defects Res A 88:575-581
8. Coffa J, van de Wiel M, Disodado B, Carvalho B, Schouten J, Meijer G (2008) MLPAnalyzer: data analysis tool for reliable automated normalization of MLPA fragment data. Cellular Oncology 30:323-335 (Pubitemid 352032908)
9. Danam R, Howell S, Brent T, Harris L (2005) Epigenetic regulation of O6 methylguanine DNA methyltransferase gene expression by histone acetylation and methyl CpG binding proteins. Mol Cancer Ther 4:61-69 (Pubitemid 40268067)
10. Ehrich M, Nelson M, Stanssens P, Zabeau M, Liloglou T, Xinarianos G, Cantor C, Field J, van den Boom D (2005) Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci U S A 102:15785-15790 (Pubitemid 41552820)
11. Frappart P, Lee Y, Lamont J, McKinnon P (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26:2732-2741
12. Friedberg E, Meira L (2003) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 5. DNA Repair 2:501-530 (Pubitemid 36507121)
13. Gowen L, Johnson B, Latour A, Sulik K, Koller B (1996) Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet 12:191-194 (Pubitemid 26051301)
14. Hales B (2005) DNA repair disorders causing malformations. Curr Opin Genet Dev 15:234-240
15. Harris M, Juriloff D (2007) Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. Birth Defects Res A 79:187-210 (Pubitemid 46411279)
16. Jacob W, Kaplan D, Miller F (2006) The p53 family in nervous system development and disease. J Neurochem 97:1571-1584 (Pubitemid 43873653)
17. Kaina B, Christmann M, Naumann S, Roos W (2007) MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair 6:1079-1099 (Pubitemid 47058389)
18. Kisby G, Olivas A, Park T, Churchwell M, Doerge D, Samson L, Gerson S, Turker M (2009) DNA repair modulates the vulnerability of the developing brain to alkylating agents. DNA Repair (Amst) 8:400-412
19. Kitange G, Carlson B, Mladek A, Decker P, Schroeder M, Wu W, Grogan P, Giannini C, Ballman K, Buckner J, James C, Sarkaria J (2009) Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft. Model J Neurooncol 92:23-31
20. Kocabas M, Crosby J, Ross P, Otu H, Beyhan Z, Can H, Tam W, Rosa G, Halgren G, Lim B (2006) The transcriptome of human oocytes. Proc Natl Acad Sci USA 103:14027-14032 (Pubitemid 44452974)
21. Leck I (1983) Epidemiological clues to the causation of neural tube defects. In: Dobbins J (ed) Prevention of spina bifida and other neural tube defects. Academic, New York, p 155
22. Li ZW, Ren A, Zhang L, Guo Z, Li Z (2006) A population-based case-control study of risk factors for neural tube defects in four high-prevalence areas of Shanxi province, China. Pediatr Perinatal Epidemiol 20:43-53
23. Li Wang, Fang Wang, Jing Guan, Jing Le, Lihua Wu, Jizhen Zou, Huizhi Zhao, Lijun Pei, Xiaoying Zheng, Ting Zhang (2010) Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am J Clin Nutr 91:1359-1367
24. Murgatroyd C, Patchev A, Wu Y, Micale V, Bockmuhl Y, Fischer D, Holsboer F, Wotjak C, Almeida O, Spengler D (2009) Dynamic DNA methylation programs persistent adverse effects of early life stress. Nat Neurosci 12:1559-1566
25. Okano M, Bell D, Haber D, Li E (1999) DNA methyltransferase Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247-257 (Pubitemid 29519904)
26. Olshan A, Shaw G, Millikan R, Laurent C, Finnell R (2005) Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts. Am J Med Genet 135A:268-273 (Pubitemid 40756651)
27. 6-methylguanine-DNA methyltransferase in malignant human glioma cell lines. Carcinogenesis 12:1739-1744
28. 6-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation. Int J Cancer 84:416-420
29. Sah V, Attardi L, Mulligan G, Williams B, Bronson R, Jacks T (1995) A subset of p53-deficient embryos exhibit exencephaly. Nature Genet 10:175-180
30. Sarter B, Long T, Tsong W, Koh W, Yu M, Laird P (2005) Sex differential in methylation patterns of selected genes in Singapore Chinese. Hum Genet 117:402-403 (Pubitemid 41194568)
31. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Prot 3:1101-1108 (Pubitemid 351818697)
32. Topczewska J, Postovit L, Margaryan N, Sam A, Hess A, Wheaton W, Nickoloff B, Topczewski J (2006) Embryonic and tumorigenic pathways converge via nodal signaling: role in melanoma aggressiveness. Nat Med 12:925-932 (Pubitemid 44175144)