The role of XPD in cell apoptosis and viability and its relationship with p53 and cdk2 in hepatoma cells

Medical Oncology

Volumn 29, Issue 1, 2012, Pages 161-167

  Wang, Hong Yun ^a,b   Xiong, Gao Fei ^a,b   Zhang, Ji Xiang ^a,b   Xu, Hong ^a   Guo, Wu Hua ^b   Xu, Jiang Jing ^a,b   Xiong, Xiang Yang ^a  

^a NANCHANG UNIVERSITY   (China)

^b Jiangxi Provincial Key Laboratory of Molecular Medicine   (China)

Author keywords

Apoptosis; Cell cycle arrest; Hepatoma; p53; Viability; XPD

Indexed keywords

MESSENGER RNA; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE 2 GENE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; XERODERMA PIGMENTOSUM GROUP D GENE;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SEPARATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 2; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 84859648426     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-9818-y     Document Type: Article

References (28)

1. Emmert S, Leibeling D, Rünger TM. Syndromes with genetic instability: model diseases for (skin) cancerogenesis. J Dtsch Dermatol Ges. 2006;4:721-31. (Pubitemid 44356947)
2. Zhang J, Powell SN. The role of the BRCA1 tumor suppressor in DNA double-strand break repair. Mol Cancer Res. 2005;3:531-9. (Pubitemid 41567272)
3. Nakajima S, Lan L, Kanno S, Takao M, Yamamoto K, Eker AP, Yasui A. UV light-induced DNA damage and tolerance for the survival of nucleotide excision repair-deficient human cells. J Biol Chem. 2004;279:46674-7. (Pubitemid 39518314)
4. Lehmann AR. DNA repair-deficient diseases, xeroderma pigmen-tosum, Cockayne syndrome and trichothiodystrophy. Biochimie. 2003;85:1101-11. (Pubitemid 38142364)
5. Sung P, Bailly V, Weber C, Thompson LH, Prakash L, Prakash S. Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature. 1993;365:852-5. (Pubitemid 23341030)
6. Coin F, Marinoni J-C, Rodolfo C, Fribourg S, Pedrini AM, Egly J-M. Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH. Nature Genet. 1998;20:184-8. (Pubitemid 28455453)
7. Lainé JP, Mocquet V, Bonfanti M, Braun C, Egly JM, Brousset P. Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription. DNA Repair (Amst). 2007;6:1264-70. (Pubitemid 47243714)
8. Robles AI, Harris CC. p53-mediated apoptosis and genomic instability diseases. Acta Oncol. 2001;40:696-701. (Pubitemid 33081977)
9. Askin DF, Diehl-Jones WL. The neonatal liver: part III: patho-physiology of liver dysfunction. Neonatal Netw. 2003;22:5-15.
10. Becker SA, Lee TH, Butel JS, Slagle BL. Hepatitis B virus X protein interferes with cellular DNA repair. J Virol. 1998;72: 266-72. (Pubitemid 28048836)
11. Jaitovich-Groisman I, Benlimame N, Slagle BL, Perez MH, Alpert L, Song DJ, Fotouhi-Ardakani N, Galipeau J, Alaoui-Jamali MA. Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue. J Biol Chem. 2001;276:14124-32.
12. Uhring M, Poterszman A. DNA helicases and human diseases. Med Sci (Paris). 2006;22:1087-94. (Pubitemid 46032855)
13. Capovilla A, Arbuthnot P. Nucleotide excision repair by extracts of human fetal hepatocytes. FEBS Lett. 2002;518:144-8. (Pubitemid 34454981)
14. Robles AI, Wang XW, Harris CC. Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death. Oncogene. 1999;18:4681-8. (Pubitemid 29417743)
15. Jia L, Wang XW, Harris CC. Hepatitis B virus X protein inhibits nucleotide excision repair. Int J Cancer. 1999;80:875-9. (Pubitemid 29108863)
16. Giebler HA, Lemasson I, Nyborg JK. p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation. Mol Cell Biol. 2000;20: 4849-58. (Pubitemid 30396131)
17. Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR, Deng CX, Hanawalt PC, Fornace AJ Jr. p53-med-iated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol. 2000; 20:3705-14. (Pubitemid 30243916)
18. Léveillard T, Andera L, Bissonnette N, Schaeffer L, Bracco L, Egly JM, Wasylyk B. Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations. EMBO J. 1996;15:1615-24. (Pubitemid 26112383)
19. Wang XW, Vermeulen W, Coursen JD, Gibson M, Lupold SE, Forrester K, Xu G, Elmore L, Yeh H, Hoeijmakers JH, Harris CC. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev. 1996;10:1219-32. (Pubitemid 26171103)
20. Cadoret A, Ovejero C, Saadi-Kheddouci S, Souil E, Fabre M, Romagnolo B, Kahn A, Perret C. Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin. Cancer Res. 2001;61:3245-9. (Pubitemid 32695006)
21. Calvisi DF, Ladu S, Hironaka K, Factor VM, Thorgeirsson SS. Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer. J Hepatol. 2004;41:815-22. (Pubitemid 39434312)
22. Hamajima N, Saito T, Matsuo K, Suzuki T, Nakamura T, Matsuura A, Okuma K, Tajima K. Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients. J Epidemiol. 2002;12:229-36. (Pubitemid 44235006)
23. Liu J, Akoulitchev S, Weber A, Ge H, Chuikov S, Libutti D, Wang XW, Conaway JW, Harris CC, Conaway RC, Reinberg D, Levens D. Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum. Cell. 2001;104:353-63. (Pubitemid 32206456)
24. Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D. The FBP interacting repressor targets TFIIH to inhibit activated transcription. Mol Cell. 2000;5:331-41. (Pubitemid 30628091)
25. Weber A, Liu J, Collins I, Levens D. TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression. Mol Cell Biol. 2005;25:147-61. (Pubitemid 40039807)
26. Adamczewski JP, Rossignol M, Tassan JP, Nigg EA, Moncollin V, Egly JM. MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH. EMBO J. 1996;15:1877-84. (Pubitemid 26119692)
27. Lolli G, Johnson LN. Recognition of Cdk2 by Cdk7. Proteins. 2007;67:1048-59. (Pubitemid 46753950)
28. Chen J, Larochelle S, Li X, Suter B. Xpd/Ercc2 regulates CAK activity and mitotic progression. Nature. 2003;424:228-32. (Pubitemid 36858694)