Functional regulatory variants of MCL1 contribute to enhanced promoter activity and reduced risk of lung cancer in nonsmokers: Implications for context-dependent phenotype of an antiapoptotic and antiproliferative gene in solid tumor

Cancer

Volumn 118, Issue 8, 2012, Pages 2085-2095

  Jiang, Yan ^a   Wang, Wenjing ^b   Wang, Jiucun ^a   Lu, Ye ^b   Chen, Yanmei ^a   Jin, Li ^a   Lin, Dongxin ^c,d,e   He, Fuchu ^a   Wang, Haijian ^a  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Municipal Center for Disease Control and Prevention   (China)

^c CANCER HOSPITAL   (China)

^d BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^e INSTITUTE FOR ADVANCED STUDY   (United States)

Author keywords

case control study; lung cancer; MCL1; regulatory polymorphism; transcription

Indexed keywords

ADULT; ARTICLE; CANCER CELL; CANCER RISK; CASE CONTROL STUDY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSERTIONAL POLYORPHISM; LUNG ADENOCARCINOMA; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MYELOID CELL LEUKEMIA SEQUENCE 1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RISK REDUCTION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SOLID TUMOR; TRANSACTIVATION;

ADENOCARCINOMA; AGED; APOPTOSIS; CASE-CONTROL STUDIES; CELL PROLIFERATION; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; RISK FACTORS; SMOKING; TRANSCRIPTIONAL ACTIVATION;

EID: 84859638953     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26502     Document Type: Article

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