메뉴 건너뛰기




Volumn 21, Issue 3, 2012, Pages 258-263

The glomerular endothelium: New insights on function and structure

Author keywords

angiopoietin; endothelial surface layer; endothelium; glomerulus; glycocalyx; permeability; podocyte; proteinuria; vascular endothelial growth factor

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANGIOPOIETIN; ANGIOPOIETIN 4; CONNEXIN 37; CONNEXIN 43; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EXENDIN 4; GAP JUNCTION PROTEIN; GLUCOSE; GLUCOSE TRANSPORTER 1; INTERCELLULAR ADHESION MOLECULE 1; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN A;

EID: 84859628352     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3283522e7a     Document Type: Review
Times cited : (74)

References (38)
  • 1
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • DOI 10.1152/physrev.00055.2006
    • Haraldsson B, Nyström J, Deen WM. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 2008; 88:451-487. (Pubitemid 351522745)
    • (2008) Physiological Reviews , vol.88 , Issue.2 , pp. 451-487
    • Haraldsson, B.1    Nystrom, J.2    Deen, W.M.3
  • 3
    • 0017293323 scopus 로고
    • Distribution of endogenous albumin in the rat glomerulus: Role of hemodynamic factors in glomerular barrier function
    • Ryan GB, Karnovsky MJ. Distribution of endogenous albumin in the rat glomerulus: role of hemodynamic factors in glomerular barrier function. Kidney Int 1976; 9:36-45.
    • (1976) Kidney Int , vol.9 , pp. 36-45
    • Ryan, G.B.1    Karnovsky, M.J.2
  • 4
    • 80053344681 scopus 로고    scopus 로고
    • Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase
    • Effects of shear stress on glomerular endothelial cells
    • Bevan HS, Slater SC, Clarke H, et al. Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 2011; 301: F733-F742. Effects of shear stress on glomerular endothelial cells.
    • (2011) Am J Physiol Renal Physiol , vol.301
    • Bevan, H.S.1    Slater, S.C.2    Clarke, H.3
  • 5
    • 84859636533 scopus 로고    scopus 로고
    • Deterioration of glomerular endothelial surface layer and the alteration in the renal function after a growth promoter boldenone injection in rabbits
    • [Epub ahead of print] Study of the effect of boldenone on the endothelial surface layer
    • Alm-Eldeen A, Tousson E. Deterioration of glomerular endothelial surface layer and the alteration in the renal function after a growth promoter boldenone injection in rabbits. Hum Exp Toxicol 2011. [Epub ahead of print] Study of the effect of boldenone on the endothelial surface layer.
    • (2011) Hum Exp Toxicol
    • Alm-Eldeen, A.1    Tousson, E.2
  • 6
    • 78650159484 scopus 로고    scopus 로고
    • Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice
    • Chronic enzymatic degradation of the ESL
    • Meuwese MC, Broekhuizen LN, Kuikhoven M, et al. Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice. PLoS One 2010; 5:e14262. Chronic enzymatic degradation of the ESL.
    • (2010) PLoS One , vol.5
    • Meuwese, M.C.1    Broekhuizen, L.N.2    Kuikhoven, M.3
  • 7
    • 77955554252 scopus 로고    scopus 로고
    • Deterioration of glomerular endothelial surface layer induced by oxidative stress is implicated in altered permeability of macromolecules in Zucker fatty rats
    • A study showing the deterioration of the glomerular ESL in diabetic rats
    • Kuwabara A, Satoh M, Tomita N, et al. Deterioration of glomerular endothelial surface layer induced by oxidative stress is implicated in altered permeability of macromolecules in Zucker fatty rats. Diabetologia 2010; 53:2056-2065. A study showing the deterioration of the glomerular ESL in diabetic rats.
    • (2010) Diabetologia , vol.53 , pp. 2056-2065
    • Kuwabara, A.1    Satoh, M.2    Tomita, N.3
  • 8
    • 58149504280 scopus 로고    scopus 로고
    • Adriamycin alters glomerular endothelium to induce proteinuria
    • Jeansson M, Bjorck K, Tenstad O, Haraldsson B. Adriamycin alters glomerular endothelium to induce proteinuria. J Am Soc Nephrol 2009; 20:114-122.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 114-122
    • Jeansson, M.1    Bjorck, K.2    Tenstad, O.3    Haraldsson, B.4
  • 9
    • 79957801362 scopus 로고    scopus 로고
    • The glomerular endothelial cell coat is essential for glomerular filtration
    • This study is the first attempt to analyze the components of the renal endothelial cell coat. It uses a unique technique to collect cell coat components and protein expression with LC-MS to quantitate the information
    • Fridén V, Oveland E, Tenstad O, et al. The glomerular endothelial cell coat is essential for glomerular filtration. Kidney Int 2011; 79:1322-1330. This study is the first attempt to analyze the components of the renal endothelial cell coat. It uses a unique technique to collect cell coat components and protein expression with LC-MS to quantitate the information.
    • (2011) Kidney Int , vol.79 , pp. 1322-1330
    • Fridén, V.1    Oveland, E.2    Tenstad, O.3
  • 10
    • 0023158691 scopus 로고
    • Orosomucoid as one of the serum components contributing to normal capillary permselectivity in rat skeletal muscle
    • Haraldsson B, Rippe B. Orosomucoid as one of the serum components contributing to normal capillary permselectivity in rat skeletal muscle. Acta Physiol Scand 1987; 129:127-135. (Pubitemid 17037771)
    • (1987) Acta Physiologica Scandinavica , vol.129 , Issue.1 , pp. 127-135
    • Haraldsson, B.1    Rippe, B.2
  • 11
    • 0027396396 scopus 로고
    • Addition of purified orosomucoid preserves the glomerular permeability for albumin in isolated perfused rat kidneys
    • Johnsson E, Haraldsson B. Addition of purified orosomucoid preserves the glomerular permeability for albumin in isolated perfused rat kidneys. Acta Physiol Scand 1993; 147:1-8. (Pubitemid 23035579)
    • (1993) Acta Physiologica Scandinavica , vol.147 , Issue.1 , pp. 1-8
    • Johnsson, E.1    Haraldsson, B.2
  • 13
    • 77956528157 scopus 로고    scopus 로고
    • BTBR Ob/Ob mutant mice model progressive diabetic nephropathy
    • Hudkins KL, Pichaiwong W, Wietecha T, et al. BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. J Am Soc Nephrol 2010; 21:1533-1542.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1533-1542
    • Hudkins, K.L.1    Pichaiwong, W.2    Wietecha, T.3
  • 15
    • 78651323207 scopus 로고    scopus 로고
    • High glucose causes dysfunction of the human glomerular endothelial glycocalyx
    • Singh A, Friden V, Dasgupta I, et al. High glucose causes dysfunction of the human glomerular endothelial glycocalyx. Am J Physiol Renal Physiol 2011; 300:F40-F48.
    • (2011) Am J Physiol Renal Physiol , vol.300
    • Singh, A.1    Friden, V.2    Dasgupta, I.3
  • 16
    • 74049116659 scopus 로고    scopus 로고
    • Human glomerular endothelium: Interplay among glucose, free fatty acids, angiotensin II, and oxidative stress
    • A study on isolated glomerular endothelial cells of the effects of various agents
    • Jaimes EA, Hua P, Tian RX, Raij L. Human glomerular endothelium: interplay among glucose, free fatty acids, angiotensin II, and oxidative stress. Am J Physiol Renal Physiol 2010; 298:F125-F132. A study on isolated glomerular endothelial cells of the effects of various agents.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Jaimes, E.A.1    Hua, P.2    Tian, R.X.3    Raij, L.4
  • 17
    • 84856514036 scopus 로고    scopus 로고
    • Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability
    • Oxf A review of hyperglycemia on endothelial glomerular permeability
    • Sward P, Rippe B. Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability. Acta Physiol (Oxf) 2012; 204:294-307. A review of hyperglycemia on endothelial glomerular permeability.
    • (2012) Acta Physiol , vol.204 , pp. 294-307
    • Sward, P.1    Rippe, B.2
  • 18
    • 77952703704 scopus 로고    scopus 로고
    • Acute hyperglycemia induces rapid, reversible increases in glomerular permeability in nondiabetic rats
    • Acute effect of hyperglycemia on glomerular permeability in nondiabetic rats
    • Axelsson J, Rippe A, Rippe B. Acute hyperglycemia induces rapid, reversible increases in glomerular permeability in nondiabetic rats. Am J Physiol Renal Physiol 2010; 298:F1306-F1312. Acute effect of hyperglycemia on glomerular permeability in nondiabetic rats.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Axelsson, J.1    Rippe, A.2    Rippe, B.3
  • 19
    • 79551507167 scopus 로고    scopus 로고
    • Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure
    • The effect of Rho kinase inhibition in diabetes
    • Komers R, Oyama TT, Beard DR, et al. Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure. Kidney Int 2011; 79:432-442. The effect of Rho kinase inhibition in diabetes.
    • (2011) Kidney Int , vol.79 , pp. 432-442
    • Komers, R.1    Oyama, T.T.2    Beard, D.R.3
  • 20
    • 74049153900 scopus 로고    scopus 로고
    • Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension
    • The beneficial effects of tempol and simvastatin on the endothelial dysfunction in rats
    • Knight SF, Yuan J, Roy S, Imig JD. Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension. Am J Physiol Renal Physiol 2010; 298:F86-F94. The beneficial effects of tempol and simvastatin on the endothelial dysfunction in rats.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Knight, S.F.1    Yuan, J.2    Roy, S.3    Imig, J.D.4
  • 21
    • 77953833285 scopus 로고    scopus 로고
    • Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis
    • The role of GLUT-1 in diabetic nephropathy
    • Wang Y, Heilig K, Saunders T, et al. Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis. Am J Physiol Renal Physiol 2010; 299:F99-F111. The role of GLUT-1 in diabetic nephropathy.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Wang, Y.1    Heilig, K.2    Saunders, T.3
  • 22
    • 77953858179 scopus 로고    scopus 로고
    • Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice
    • The effect of GLUT-1 on mesangial matrix.
    • Zhang H, Schin M, Saha J, et al. Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice. Am J Physiol Renal Physiol 2010; 299:F91-F98. The effect of GLUT-1 on mesangial matrix.
    • (2010) Am J Physiol Renal Physiol , vol.299
    • Zhang, H.1    Schin, M.2    Saha, J.3
  • 23
    • 79954632427 scopus 로고    scopus 로고
    • Podocyte vascular endothelial growth factor (Vegf) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes
    • Results from an inducible, podocyte-specific transgenic mouse model with overexpression of VEGF-164
    • Veron D, Bertuccio CA, Marlier A, et al. Podocyte vascular endothelial growth factor (Vegf) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes. Diabetologia 2011; 54:1227-1241. Results from an inducible, podocyte-specific transgenic mouse model with overexpression of VEGF-164.
    • (2011) Diabetologia , vol.54 , pp. 1227-1241
    • Veron, D.1    Bertuccio, C.A.2    Marlier, A.3
  • 24
    • 79957880117 scopus 로고    scopus 로고
    • Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    • This important study reveals the role of angiopoietin during development in healthy adult animals and during conditions of injury or increased microvascular stress
    • Jeansson M, Gawlik A, Anderson G, et al. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest 2011; 121:2278-2289. This important study reveals the role of angiopoietin during development in healthy adult animals and during conditions of injury or increased microvascular stress.
    • (2011) J Clin Invest , vol.121 , pp. 2278-2289
    • Jeansson, M.1    Gawlik, A.2    Anderson, G.3
  • 25
    • 84859646862 scopus 로고    scopus 로고
    • Angiopoietin-2, endothelial dysfunction and renal involvement in patients with systemic lupus erythematosus
    • doi:10.5301/jn.5000030. [Epub ahead of print] The effect of Angiopoeitin-2 and endothelial dysfunction
    • El-Banawy HS, Gaber EW, Maharem DA, Matrawy KA. Angiopoietin-2, endothelial dysfunction and renal involvement in patients with systemic lupus erythematosus. J Nephrol 2011. doi:10.5301/jn.5000030. [Epub ahead of print] The effect of Angiopoeitin-2 and endothelial dysfunction.
    • (2011) J Nephrol
    • El-Banawy, H.S.1    Gaber, E.W.2    Maharem, D.A.3    Matrawy, K.A.4
  • 27
    • 78651252297 scopus 로고    scopus 로고
    • Podocyte-secreted angiopoietinlike- 4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome
    • In this interesting study, it was found that podocytes secrete angiopoietin-like 4 and that this protein mediates the proteinuria observed in glucocorticoidsensitive nephrotic syndrome
    • Clement LC, Avila-Casado C, Mace C, et al. Podocyte-secreted angiopoietinlike- 4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med 2011; 17:117-122. In this interesting study, it was found that podocytes secrete angiopoietin-like 4 and that this protein mediates the proteinuria observed in glucocorticoidsensitive nephrotic syndrome.
    • (2011) Nat Med , vol.17 , pp. 117-122
    • Clement, L.C.1    Avila-Casado, C.2    Mace, C.3
  • 28
    • 80053637525 scopus 로고    scopus 로고
    • ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters
    • This study shows that angiopoietin-like-4 causes endothelial damage, which gives important clues to the interpretation of the work by Clement et al. [27]
    • Huang RL, Teo Z, Chong HC, et al. ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters. Blood 2011; 118:3990-4002. This study shows that angiopoietin-like-4 causes endothelial damage, which gives important clues to the interpretation of the work by Clement et al. [27].
    • (2011) Blood , vol.118 , pp. 3990-4002
    • Huang, R.L.1    Teo, Z.2    Chong, H.C.3
  • 31
    • 80054686069 scopus 로고    scopus 로고
    • Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice
    • A study showing that angiopoietin-like-4 acts on the endothelium, see also Clement et al. [27]
    • Perdiguero EG, Galaup A, Durand M, et al. Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice. J Biol Chem 2011; 286:36841-36851. A study showing that angiopoietin-like-4 acts on the endothelium, see also Clement et al. [27].
    • (2011) J Biol Chem , vol.286 , pp. 36841-36851
    • Perdiguero, E.G.1    Galaup, A.2    Durand, M.3
  • 32
    • 79960058692 scopus 로고    scopus 로고
    • Alteration of connexin expression is an early signal for chronic kidney disease
    • The distribution of connexins in kidney disease
    • Toubas J, Beck S, Pageaud AL, et al. Alteration of connexin expression is an early signal for chronic kidney disease. Am J Physiol Renal Physiol 2011; 301:F24-F32. The distribution of connexins in kidney disease.
    • (2011) Am J Physiol Renal Physiol , vol.301
    • Toubas, J.1    Beck, S.2    Pageaud, A.L.3
  • 33
    • 80052681811 scopus 로고    scopus 로고
    • Involvement of MAPKs in ICAM-1 expression in glomerular endothelial cells in diabetic nephropathy
    • Watanabe N, Shikata K, Shikata Y, et al. Involvement of MAPKs in ICAM-1 expression in glomerular endothelial cells in diabetic nephropathy. Acta Med Okayama 2011; 65:247-257.
    • (2011) Acta Med Okayama , vol.65 , pp. 247-257
    • Watanabe, N.1    Shikata, K.2    Shikata, Y.3
  • 34
    • 79953826349 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
    • Kodera R, Shikata K, Kataoka HU, et al. Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Diabetologia 2011; 54:965-978.
    • (2011) Diabetologia , vol.54 , pp. 965-978
    • Kodera, R.1    Shikata, K.2    Kataoka, H.U.3
  • 35
    • 79951919933 scopus 로고    scopus 로고
    • Protective effect of photodegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells
    • The oxidative stress of glomerular endothelial cells induced by TNF can be ameliorated by a degradation product of nifedipine
    • Fukuhara Y, Tsuchiya K, Horinouchi Y, et al. Protective effect of photodegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells. J Med Invest 2011; 58:118-126. The oxidative stress of glomerular endothelial cells induced by TNF can be ameliorated by a degradation product of nifedipine.
    • (2011) J Med Invest , vol.58 , pp. 118-126
    • Fukuhara, Y.1    Tsuchiya, K.2    Horinouchi, Y.3
  • 36
    • 77952691580 scopus 로고    scopus 로고
    • CLIC5A, a component of the ezrinpodocalyxin complex in glomeruli, is a determinant of podocyte integrity
    • CLIC-5 is a highly glomerular-enriched gene (x800-fold), which is part of the ezrin-podocalyxin complex
    • Wegner B, Al-Momany A, Kulak SC, et al. CLIC5A, a component of the ezrinpodocalyxin complex in glomeruli, is a determinant of podocyte integrity. Am J Physiol Renal Physiol 2010; 298:F1492-F1503. CLIC-5 is a highly glomerular-enriched gene (x800-fold), which is part of the ezrin-podocalyxin complex.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Wegner, B.1    Al-Momany, A.2    Kulak, S.C.3
  • 37
    • 84859636532 scopus 로고    scopus 로고
    • Role of endothelin-1 in podocyte-toendothelial cross-talk in podocytopathies
    • Philadelphia, PA, USA: Am. Soc. Nephrology
    • Daehn IS, Zhang T, Casalena G, et al. Role of endothelin-1 in podocyte-toendothelial cross-talk in podocytopathies. In ASN annual meeting: Kidney Week. Philadelphia, PA, USA: Am. Soc. Nephrology; 2011:FR-OR297.
    • (2011) ASN Annual Meeting: Kidney Week
    • Daehn, I.S.1    Zhang, T.2    Casalena, G.3
  • 38
    • 79951820036 scopus 로고    scopus 로고
    • Mesangial cell integrin alphavbeta8 provides glomerular endothelial cell cytoprotection by sequestering TGFbeta and regulating PECAM-1
    • This study reveals an interesting communication between mesangial and endothelial cells. It also shows how TGF-β can be inactivated by the mesangial cells
    • Khan S, Lakhe-Reddy S, McCarty JH, et al. Mesangial cell integrin alphavbeta8 provides glomerular endothelial cell cytoprotection by sequestering TGFbeta and regulating PECAM-1. Am J Pathol 2011; 178:609-620. This study reveals an interesting communication between mesangial and endothelial cells. It also shows how TGF-β can be inactivated by the mesangial cells.
    • (2011) Am J Pathol , vol.178 , pp. 609-620
    • Khan, S.1    Lakhe-Reddy, S.2    McCarty, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.