A genome-wide association study of female sexual dysfunction

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Burri, Andrea ^a,b   Hysi, Pirro ^b   Clop, Alex ^c   Rahman, Qazi ^a   Spector, Tim D ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; 4 AMINOBUTYRIC ACID; SEROTONIN RECEPTOR;

5 HYDROXYTRYPTAMINE RECEPTOR 1E GENE; 5HT2A GENE; ADULT; AGED; ARTICLE; CHROMOSOME 6; DISEASE REGISTRY; DRD4 GENE; FEMALE; FEMALE SEXUAL DYSFUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; HUMAN GENOME; IL 1B GENE; MAJOR CLINICAL STUDY; PHENOTYPE; POPULATION RESEARCH; SEROTONIN BRAIN LEVEL; SEXUALITY; SINGLE NUCLEOTIDE POLYMORPHISM; TWINS; ALLELE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; SEXUAL DYSFUNCTION;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; CHROMOSOMES, HUMAN, PAIR 6; FEMALE; GAMMA-AMINOBUTYRIC ACID; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, SEROTONIN; SEROTONIN; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 84859620148     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035041     Document Type: Article

References (45)

1. Laumann EO, Paik A, Rosen RC, (1999) Sexual Dysfunction in the United States. Prevalence and predictors. JAMA 281: 537-44.
2. Rosen RC, Taylor JF, Leiblum SR, Bachmann GA, (1993) Prevalence of sexual dysfunction in women: Results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 19: 171-88.
3. Burri A, Spector T, (2011) Recent and lifelong sexual dysfunctions in a female UK population sample: prevalence and risk factors. J Sex Med 8: 2420-2430.
4. Derogatis LR, Burnett AL, (2008) The epidemiology of sexual dysfunctions. J Sex Med 5: 289-300.
5. Hawton DM, Gath D, Day A, (2000) Sexual Function in a Community Sample of Middle-Aged Women with Partners: Effects of Age, Marital, Socioeconomic, Psychiatric, Gynecological, and Menopausal Factors. Arch Sex Behav 23: 375-395.
6. Basson R, Berman J, Burnett A, Derogatis L, Ferguson D, et al. (2000) Report of the international consensus development conference on female sexual dysfunction: Definitions and classifications. J Urol 163: 888-893.
7. Basson R, Althof S, David S, Fugl-Meyer K, Goldstein I, (2004) Summary of the recommendations on sexual dysfunctions in women. J Sex Med 1: 24-34.
8. Witting K, Santilla P, Rijsdijk F, Varjonen M, Stern P, et al. (2008) Correlated genetic and non-shared environmental influences account for the comorbidity between female sexual dysfunctions. Psychol Med 26: 1-13.
9. Dawood K, Kirk KM, Bailey JM, Andrews PW, Martin NG, (2008) Genetic and environmental influences on the frequency of orgasm in women. Twin Res Hum Genet 8: 27-33.
10. Dunn KM, Cherkas LF, Spector TD, (2005) Genetic on variation in female orgasmic function: A twin study. Biol Lett 22: 260-26.
11. Hettema JM, Neale MC, Kendler KS, (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatr 158: 1568-15.
12. Sullivan PF, Neale MC, Kendler KS, (2000) Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatr 157: 1552-15.
13. Jang K, Wesley WJ, Vemon PA, (1996) Heritability of the Big Five Personality Dimensions and Their Facets: A Twin Study. J of Pers 64: 577-591.
14. Bishop JR, Moline J, Ellingrod VL, Schultz SK, Clayton AH, (2006) Serotonin 2A-1438 G/A and G-protein Beta3 subunit C825T polymorphismms in patients with depression and SSRI-associated sexual side-effects. Neuropsychopharmacol 31: 2281-2288.
15. Ben Zion IZ, Tessler R, Cohen L, Lerer E, Raz Y, Bachner- Melman R, et al. (2006) Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire, arousal and sexual function. Mol Psychiatry 11: 782-786.
16. Gerber S, Bongiovanni AM, Ledger WJ, Witkin SS, (2003) Interleukin- 1beta gene polymorphism in women with vulvar vestibulitis syndrome. Eur J Obstet Gynecol Reprod Biol 107: 74-7.
17. Spector T, Williams F, (2006) The UK Adult Twin Registry (TwinsUK). Twin Res Hum Genet 9: 899-906.
18. Andrews T, Hart DJ, Snieder H, de Lange M, Spector TD, et al. (2001) Are twins and singletons comparable? A study of disease-related and lifestyle characteristics. Twin Res Hum Genet 4: 464-77.
19. Snieder H, MacGregor AJ, Spector TD, (1998) Genes control the cessation of a woman's reproductive life: a twin study of hysterectomy and age at menopause. J Clin Endocrinol Metab 83: 1875-1880.
20. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, et al. (2000) The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Mar Ther 26: 191-208.
21. Burri A, Cherkas L, Spector T, (2010) Replication of psychometric properties of the FSFI and validation of a modified version (FSFI-LL) assessing lifelong sexual function in an unselected sample of females. J Sex Med 7: 3929-39.
22. Marcini J, Howie B, Myers S, McVean G, Donnelly P, (2009) A new multipoint method for genome-wide association studies via imputation of genotypes. Nat Genet 39: 906-913.
23. Chen WM, Abecasis R, (2007) Family-based association tests for genomewide association scans. Am J Hum Genet 81: 913-26.
24. Marcini J, Howie B, Myers S, McVean G, Donnelly P, (2009) A new multipoint method for genome-wide association studies via imputation of genotypes. Nat Genet 39: 906-913.
25. Dudbridge F, Gusnanto A, (2008) Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 32: 227-234.
26. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, et al. (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 49: 986-90.
27. UK IBD Genetics Consortium, Barrett JC, Lee JC, Lees CW, Prescott NJ. (2009) Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet 41: 1330-4.
28. Genetic Analysis of Psoriasis Consortium, the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC. (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 42: 985-90.
29. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, et al. (2009): Collaborative Association Study of Psoriasis. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 41: 199-204.
30. Wasserman NF, Aneas I, Nobrega MA, (2010) An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer. Genome Res 20: 1191-7.
31. Ghoussaini M, Song H, Koessler T, Al Olama AA, Kote-Jarai Z, et al. (2008) UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators. Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst 100: 962-6.
32. Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, et al. (2011) 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature 470: 264-8.
33. Barone P, Jordan D, Atger F, Kopp N, Fillion G, (1994) Quantitative autoradiography of 5-HT1D and 5-HT1E binding sites labelled by [3H]5-HT, in frontal cortex and the hippocampal region of the human brain. Brain Res 638: 85-94.
34. Shimron-Abarbanell D, Nothen MM, Erdmann J, Propping P, (1995): Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation. Mol Brain Res 29: 387-390.
35. Frohlich PF, Meston CM, (2000) Evidence that serotonin affects female sexual functioning via peripheral mechanisms. Physiol Behav 71: 383-93.
36. Zajecka J, (2001) Strategies for the treatment of antidepressant-related sexual dysfunction. J Clin Psychiatry 62: 35-43.
37. Frazer A, Hensler JG, (1999) Serotonin. In: GJ InSiegel, BW Agranoff, RW Albers, FisherSK, editors. Uhler MD (eds.) Basic Neurochemistry. Lippincott-Raven Philadelphia, PA.
38. Wada S, Yamada S, Yamanouchi K, (2008) Additive inhibition of lordosis by simultaneous treatments with GABA(A) and GABA(B) receptor agonists, muscimol and baclofen, in female rats. Pharmacol Biochem Res 90: 590-3.
39. Frye CA, Paris JJ, (2011) Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats. Psychopharmacology 213: 93-103.
40. Kogan MI, Kalinchenko SI, Avadieva NE, (2009) Sexual dysfunction in Russia: risk factors for women. Urologiia 5: 8-12.
41. Ponholzer A, Roehlich M, Racz U, Temml C, Madersbacher S, (2005) Female sexual dysfunction in a healthy Austrian cohort: prevalence and risk factors. Eur Urol 47: 366-74.
42. Doyon Y, Selleck W, Lane WS, (2004) Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol 24: 1884-96.
43. Kim JR, Kee HJ, Kim JY, Joung H, Nam KI, et al. (2009) Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation. J Biol Chem 284: 16308-16.
44. Bell JT, Spector TD, (2011) A twin approach to unraveling epigenetics. Trends in Genetics 27: 116-125.
45. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2229.