Additive inhibition of lordosis by simultaneous treatments with GABAA and GABAB receptor agonists, muscimol and baclofen, in female rats

Pharmacology Biochemistry and Behavior

Volumn 90, Issue 4, 2008, Pages 590-593

  Wada, Shizuko ^a   Yamada, Shunji ^a   Yamanouchi, Korehito ^a  

^a Neuroendocrinology   (Japan)

Author keywords

Baclofen; Female rat; GABAA receptor; GABAB receptor; Lordosis; Muscimol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; ESTROGEN; MUSCIMOL; RECEPTOR SUBTYPE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; LORDOSIS QUOTIENT; NONHUMAN; PARAMETER; PRIORITY JOURNAL; RAT; RAT STRAIN; REGULATORY MECHANISM; SEXUAL BEHAVIOR;

ANIMALS; BACLOFEN; ESTRADIOL; FEMALE; GABA AGONISTS; MUSCIMOL; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, GABA-B; SEXUAL BEHAVIOR, ANIMAL;

RATTUS;

EID: 48749105020     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.04.020     Document Type: Article

References (39)

1. Ågmo A., Soria P., and Paredes R. GABAergic drugs and lordosis behavior in the female rat. Horm Behav 23 (1989) 368-380
2. Baefield R.J., and Chen J.J. Activation of estrous behavior in ovariectomized rats by intracerebral implants of estradiol benzoate. Endocrinol 101 (1977) 1716-1725
3. Barnard E.A., Darlison M.G., and Seeburg P. Molecular biology of the GABAA receptor: the receptor/channel superfamily. TINS 10 (1987) 502-509
4. B receptor site distribution in the rat central nervous system. Neurosci 20 (1987) 365-383
5. Bowery N.G., Bettler B., Froestl W., Gallagher J.P., Marshall F., Raiteri M., et al. Int Union Pharmacol. XXXIII. Mammalian gamma-aminobutyric acid (B) receptors: structure and function. Pharmacol Rev 54 (2002) 247-264
6. Caggiula A.R., Herndon Jr. J.G., Scanlon R., Greenstone D., Bradshaw W., and Sharp D. Dissociation of active from immobility components of sexual behavior in female rats by central 6-hydroxydopamine: implications for CA involvement in sexual behavior and sensorimotor responsiveness. Brain Res 172 (1979) 505-520
7. Chan-Palay V., Jonsson G., and Palay S.L. Serotonin and substance P coexist in neurons of the rat's central nervous system. Proc. Natl. Acad. Sci. USA 75 (1978) 1582-1586
8. Foreman M.M., and Moss R.L. Role of hypothalamic dopaminergic receptors in the control of lordosis behavior in the female rat. Physiol Behav 22 (1979) 283-289
9. 1A receptor interaction in the mediobasal hypothalamus. Brain Res 1027 (2004) 144-150
10. Hamon M., Goetz C., Euvrard C., Pasqualini C., Le Dafniet M., Kerdelhue B., et al. Biochemical and functional alterations of central GABA receptors during chronic estradiol treatment. Brain Res 279 (1983) 141-152
11. A receptor beta 2/bata 3 subunits on supraoptic oxytocin neurons. J Neuroimmunol 6 (1994) 5-11
12. Hoffman C.S., Westin T.M., Miner H.M., Johnson P.L., Summfers C.H., and Renner K.J. GABAergic drugs alter hypothalamic cartooning release and lordosis in estrogen-primed rats. Brain Res 946 (2002) 96-103
13. Kakeyama M., and Yamanouchi K. Lordosis in male rats: the facilitatory effect of mesencephalic dorsal raphe nucleus lesion. Physiol Behav 51 (1992) 181-184
14. Kakeyama M., and Yamanouchi K. Inhibitory effect of baclofen on lordosis in female and male rats with dorsal raphe nucleus lesion or septal cut. Neuroendocrinol 63 (1996) 290-296
15. 1A receptor agonists on lordosis in female rats. Zool Sci 20 (2003) 1133-1138
16. 1A-receptor agonist, 8-OH-DPAT, and GABAB-receptor agonist, baclofen, on lordosis in female rats with lesions in either the dorsal raphe nucleus or septum. J Pharmacol Sci 98 (2005) 419-424
17. B receptors. Neurosci Res 17 (1993) 91-99
18. Lagrange A.H., Wagner E.J., Rønnekleiv O.K., and Kelly M.J. Estrogen rapidly attenuates a GABAB response in hypothalamic neurons. Neuroendocrinol 64 (1996) 114-123
19. Luine, Cowell J., and Frankfurt M. GABAergic-serotonergic interactions in regulating lordosis. Brain Res 556 (1991) 171-174
20. Mascó D., Weigel R., and Carrer H.F. Gamma aminobutyric acid mediates ventromedial hypothalamic mechanisms controlling the execution of lordotic responses in the female rat. Behav Brain Res 19 (1986) 153-162
21. 3 receptors in the ventromedial nucleus of the hypothalamus and female sexual behavior. Brain Res 769 (1997) 13-20
22. Matsumoto R.R. GABA receptors are cellular differences reflected in function. Brain Res Rev 14 (1989) 203-225
23. McCarthy M.M. Functional significance of steroid modulation of GABAergic neurotransmission: analysis at the behavioral, cellular, and molecular levels. Horm Behav 29 (1995) 131-140
24. McCarthy M.M., Malik K.F., and Feder H.H. Increased GABAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in preoptic area. Brain Res 507 (1990) 40-44
25. McCarthy M.M., Pfaff D.W., and Schwartz-Giblin S. Midbrain central gray GABAA receptor activation enhances and blockade reduces, sexual behavior in the female rat. Exp Brain Res 86 (1991) 108-116
26. McCarthy M.M., Master D.B., Fiber J.M., Lopez-Colme A.M., Beyer C., Komisark B.R., et al. GABAergic control of receptivity in the female rat. Neuroendocrinol 53 (1991) 473-479
27. Ottersen O.P., Hjelle O.P., Osen K.K., and Laake J.H. Amino acid transmitters. In: Paxinos G. (Ed). The rat nervous system. 2nd ed (1995) 1017-1037
28. Pfaff D.W., Sakuma Y., Kow L.M., Lee A.W.L., and Easton A. Hormonal, neural, and genomic mechanisms for female reproductive behaviors, motivation, and arousal. In: Knobil E., and Neil J.D. (Eds). Knobil and Neill's Physiology of Reproduction (2006), Elsevier, New York 1825-1920
29. A receptors immunocytochemical distribution of 13 subunits in the adult rat brain. Neurosci 101 (2000) 815-850
30. Qureshi G.A., Bednar I., Forsberg B.G., and Södersten P. GABA inhibits sexual behaviour in female rats. Neurosci 27 (1988) 169-174
31. Sakuma Y., and Pfaff D.W. Mesencephalic mechanisms for integration of female reproductive behavior in the rat. Am J Physiol 237 (1979) R285-R290
32. Salzberg H.C., Lonstein J.S., and Stern J.M. GABA receptor regulation of kyphotic nursing and female sexual behavior in the caudal ventrolateral periaqueductal gray of postpartum rats. Neurosci 114 (2002) 675-687
33. Satou M., and Yamanouchi K. Effect of direct application of estrogen aimed at lateral septum or dorsal raphe nucleus on lordosis behavior: regional sexual differences in rats. Neuroendocrinol 69 (1999) 446-452
34. Tohyama M., and Takatsuji K. Atlas of neoroactive substances and their receptors in the rat (1988), Oxford University Press, Oxford
35. Tsukahara S., and Yamanouchi K. Neurohistological and behavioral evidence for lordosis-inhibiting tract from lateral septum to periaqueductal gray in male rats. J Comp Neurol 431 (2001) 293-310
36. 1A receptor antagonists and lordosis behavior. Neuropharmacol 35 (1996) 489-495
37. van Bree J.B., Heijligers-Feijen C.D., de Boer A.G., Danhof M., and Breimer D.D. Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology. Phar Res 8 (1991) 259-262
38. A receptor, and the GABABR1 and GABABR2 receptor subunit. J Comp Neurol 470 (2004) 339-356
39. Yamanouchi K. Brain mechanisms inhibiting the expression of heterotypical sexual behavior in rats. In: Maeda K.-I., Tsukamura H., and Yokoyama A. (Eds). Neural control of reproduction (1997), Karger, Basel 219-235