Retinol induces morphological alterations and proliferative focus formation through free radical-mediated activation of multiple signaling pathways

Acta Pharmacologica Sinica

Volumn 33, Issue 4, 2012, Pages 558-567

  Gelain, Daniel Pens ^a   Pasquali, Matheus Augusto De Bittencourt ^a   Caregnato, Fernanda Freitas ^a   Castro, Mauro Antonio Alves ^a   Moreira, José Claudio Fonseca ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Akt; cell deformation; ERK; JNK; oxidative stress; p38; PKA; PKC; retinol; Sertoli cell; vitamin toxicity

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE B; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; RETINOL; STRESS ACTIVATED PROTEIN KINASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TROLOX C;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CARCINOGENICITY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; INTRACELLULAR SIGNALING; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SERTOLI CELL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; FREE RADICALS; MALE; PROTEIN KINASES; RATS; SERTOLI CELLS; SIGNAL TRANSDUCTION; VITAMIN A; VITAMINS;

EID: 84859612145     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.202     Document Type: Article

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