Insight into the molecular basis of aromatic polyketide cyclization: Crystal structure and in vitro characterization of WhiE-ORFVI

Biochemistry

Volumn 51, Issue 14, 2012, Pages 3079-3091

  Lee, Ming Yue ^a   Ames, Brian D ^a   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; AROMATIC RINGS; COCRYSTAL STRUCTURE; CRITICAL DETERMINANT; DEGREE OF SIMILARITY; IN-VITRO; KEY CONTROL; MOLECULAR BASIS; NATURAL PRODUCTS; POLYCYCLIC AROMATIC COMPOUNDS; POLYKETIDE BIOSYNTHESIS; POLYKETIDES; RECONSTITUTION ASSAY; REGIOSPECIFIC; SITE DIRECTED MUTAGENESIS; STREPTOMYCES COELICOLOR A3(2);

AROMATIC COMPOUNDS; AROMATIZATION; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; KETONES;

CYCLIZATION;

POLYCYCLIC AROMATIC COMPOUND; POLYKETIDE;

AROMATIZATION; ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; CYCLIZATION; GENE LOCUS; IN VITRO STUDY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STREPTOMYCES COELICOLOR;

AMINO ACID SEQUENCE; AROMATASE; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STREPTOMYCES COELICOLOR;

STREPTOMYCES COELICOLOR;

EID: 84859598051     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201705q     Document Type: Article

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