UAP56 is a novel interacting partner of Bcr in regulating vascular smooth muscle cell DNA synthesis

Biochemical and Biophysical Research Communications

Volumn 420, Issue 3, 2012, Pages 511-515

  Sahni, Abha ^b   Wang, Nadan ^c   Alexis, Jeffrey D ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

DExD H box protein; DNA synthesis; RNA helicase

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CYCLIN E; PROTEIN P27; RNA HELICASE; UAP56 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; GENE SILENCING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; DEAD-BOX RNA HELICASES; DNA REPLICATION; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 84859567662     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.022     Document Type: Article

References (23)

1. Fujita N., Furukawa Y., Itabashi N., Okada K., Saito T., Ishibashi S. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 2002, 283:H204-H212.
2. Jackson C.L., Schwartz S.M. Pharmacology of smooth muscle cell replication. Hypertension 1992, 20:713-736.
3. Bunkenburg B., van Amelsvoort T., Rogg H., Wood J.M. Receptor-mediated effects of angiotensin II on growth of vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension 1992, 20:746-754.
4. Naftilan A.J., Pratt R.E., Dzau V.J. Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. J. Clin. Invest. 1989, 83:1419-1424.
5. Alexis J.D., Wang N., Che W., Lerner-Marmarosh N., Sahni A., Korshunov V.A., Zou Y., Ding B., Yan C., Berk B.C., Abe J. Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells. Circ. Res. 2009, 104:69-78.
6. Spies T., Blanck G., Bresnahan M., Sands J., Strominger J.L. A new cluster of genes within the human major histocompatibility complex. Science 1989, 243:214-217.
7. Fleckner J., Zhang M., Valcarcel J., Green M.R. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 1997, 11:1864-1872.
8. Allcock R.J., Williams J.H., Price P. The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production. Genes Cells 2001, 6:487-494.
9. Shen J., Zhang L., Zhao R. Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor. J. Biol. Chem. 2007, 282:22544-22550.
10. Strasser K., Masuda S., Mason P., Pfannstiel J., Oppizzi M., Rodriguez-Navarro S., Rondon A.G., Aguilera A., Struhl K., Reed R., Hurt E. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 2002, 417:304-308.
11. Gatfield D., Le Hir H., Schmitt C., Braun I.C., Kocher T., Wilm M., Izaurralde E. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr. Biol. 2001, 11:1716-1721.
12. Kapadia F., Pryor A., Chang T.H., Johnson L.F. Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49. Gene 2006, 384:37-44.
13. Sahni A., Wang N., Alexis J.D. UAP56 is an important regulator of protein synthesis and growth in cardiomyocytes. Biochem. Biophys. Res. Commun. 2010, 393:106-110.
14. Shen H., Zheng X., Shen J., Zhang L., Zhao R., Green M.R. Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev. 2008, 22:1796-1803.
15. Yamazaki T., Fujiwara N., Yukinaga H., Ebisuya M., Shiki T., Kurihara T., Kioka N., Kambe T., Nagao M., Nishida E., Masuda S. The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. Mol. Biol. Cell 2010, 21:2953-2965.
16. Kota K.P., Wagner S.R., Huerta E., Underwood J.M., Nickerson J.A. Binding of ATP to UAP56 is necessary for mRNA export. J. Cell. Sci. 2008, 121:1526-1537.
17. Fuller-Pace F.V. DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Nucleic Acids Res. 2006, 34:4206-4215.
18. Yang L., Lin C., Zhao S., Wang H., Liu Z.R. Phosphorylation of p68 RNA helicase plays a role in platelet-derived growth factor-induced cell proliferation by up-regulating cyclin D1 and c-Myc expression. J. Biol. Chem. 2007, 282:16811-16819.
19. Attwooll C., Lazzerini Denchi E., Helin K. The E2F family: specific functions and overlapping interests. EMBO J. 2004, 23:4709-4716.
20. Chen H.Z., Tsai S.Y., Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat. Rev. Cancer 2009, 9:785-797.
21. Hochegger H., Takeda S., Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all?. Nat. Rev. Mol. Cell Biol. 2008, 9:910-916.
22. Malumbres M., Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 2009, 9:153-166.
23. Yang L., Lin C., Liu Z.R. Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation. Mol. Cancer Res. 2005, 3:355-363.