BRCA1 as tumor suppressor: Lord without its RING?

Breast Cancer Research

Volumn 14, Issue 2, 2012, Pages

  Elia, Andrew E H ^a,b,c   Elledge, Stephen J ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; CISPLATIN; OLAPARIB; UBIQUITIN PROTEIN LIGASE; BRCA1 PROTEIN, HUMAN;

ANIMAL MODEL; BREAST CANCER; CANCER INHIBITION; DNA DAMAGE; DNA REPAIR; GENOMIC INSTABILITY; IONIZING RADIATION; MISSENSE MUTATION; MOUSE; NONHUMAN; NOTE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RING FINGER MOTIF; UBIQUITINATION; UPREGULATION; ANIMAL; ARTICLE; BREAST TUMOR; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMALS; BRCA1 PROTEIN; BREAST NEOPLASMS; DNA REPAIR; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84859565331     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3118     Document Type: Note

References (15)

1. Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 2010, 11:138-148. 10.1038/nrm2831, 20029420.
2. Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 2003, 302:636-639. 10.1126/science.1088877, 14576432.
3. Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science 2003, 302:639-642. 10.1126/science.1088753, 14576433.
4. Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D 3, Fukuda M, Ohta T, Klevit R. Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex. Proc Natl Acad Sci USA 2003, 100:5646-5651. 10.1073/pnas.0836054100, 156255, 12732733.
5. Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science 2011, 334:525-528. 10.1126/science.1209909, 22034435.
6. Drost R, Bouwman P, Rottenberg S, Boon U, Schut E, Klarenbeek S, Klijn C, van der Heijden I, van der Gulden H, Wientjens E, Pieterse M, Catteau A, Green P, Solomon E, Morris JR, Jonkers J. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell 2011, 20:797-809. 10.1016/j.ccr.2011.11.014, 22172724.
7. Christensen DE, Brzovic PS, Klevit RE. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat Struct Mol Biol 2007, 14:941-948. 10.1038/nsmb1295, 17873885.
8. Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T. E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci USA 2008, 105:20876-20881. 10.1073/pnas.0811203106, 2603436, 19088202.
9. Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol 2004, 11:512-518. 10.1038/nsmb775, 15133502.
10. Morris JR, Solomon E. BRCA1:BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum Mol Genet 2004, 13:807-817. 10.1093/hmg/ddh095, 14976165.
11. Polanowska J, Martin JS, Garcia-Muse T, Petalcorin MI, Boulton SJ. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. EMBO J 2006, 25:2178-2188. 10.1038/sj.emboj.7601102, 1462971, 16628214.
12. Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S. A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell 2007, 25:663-675. 10.1016/j.molcel.2007.01.029, 17349954.
13. Ye Y, Rape M. Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol 2009, 10:755-764. 10.1038/nrm2780, 3107738, 19851334.
14. Christensen DE, Klevit RE. Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination. FEBS J 2009, 276:5381-5389. 10.1111/j.1742-4658.2009.07249.x, 2973559, 19712108.
15. Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage FH, Verma IM. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature 2011, 477:179-184. 10.1038/nature10371, 3240576, 21901007.