Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer

Cancer Letters

Volumn 320, Issue 2, 2012, Pages 180-188

  Lai, Lisa A ^a   Risques, Rosa Ana ^a   Bronner, Mary P ^b   Rabinovitch, Peter S ^a   Crispin, David ^a   Chen, Ru ^a   Brentnall, Teresa A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

BAC array; Genomic instability; Ulcerative colitis

Indexed keywords

ADULT; ARTICLE; CHROMOSOME 15Q; CHROMOSOME 15Q22; CHROMOSOME 16P; CHROMOSOME 16P13; CHROMOSOME 2Q; CHROMOSOME 2Q36; CHROMOSOME 3; CHROMOSOME 3P21; CHROMOSOME 3Q25; CHROMOSOME 4; CHROMOSOME 4P16.2; CHROMOSOME 4Q34; CLINICAL ARTICLE; COLON BIOPSY; COLON CANCER; COLON DISEASE; COLON DYSPLASIA; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE COURSE; DYSPLASIA; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; RECTUM BIOPSY; RETROSPECTIVE STUDY; ULCERATIVE COLITIS;

ADULT; COLITIS, ULCERATIVE; COLON; COLORECTAL NEOPLASMS; COMPARATIVE GENOMIC HYBRIDIZATION; DISEASE PROGRESSION; DNA COPY NUMBER VARIATIONS; GENOMIC INSTABILITY; HUMANS; MIDDLE AGED;

EID: 84859563532     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.02.031     Document Type: Article

References (36)

1. Brentnall T.A., Haggitt R.C., Rabinovitch P.S., Kimmey M.B., Bronner M.P., Levine D.S., Kowdley K.V., Stevens A.C., Crispin D.A., Emond M., Rubin C.E. Risk and natural history of colonic neoplasia in patients with primacy sclerosing cholangitis and ulcerative colitis. Gastroenterology 1996, 110:331-338.
2. Brentnall T.A. Molecular underpinnings of cancer in ulcerative colitis. Curr. Opin. Gastroen. 2003, 19:64-68.
3. Itzkowitz S.H., Harpaz N. Diagnosis and management of dysplasia in patients with inflammatory bowel diseases. Gastro 2004, 126:1634-1648.
4. Itzkowitz S.H., Present D.H. Consensus conference. colorectal cancer screening and surveillance in inflammatory bowel disease. Inflamm. Bowel Dis. 2005, 11:314-321.
5. Konda A., Duffy M.C. Surveillance of patients at increased risk of colon cancer: inflammatory bowel disease and other conditions. Gastro Clin. North America 2008, 37:191-213.
6. Risques R.A., Lai L.A., Brentnall T.A., Li L., Feng Z., Gallaher J., Mandelson M.T., Potter J.D., Bronner M.P., Rabinovitch P.S. Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastro 2008, 135:410-418.
7. Loeb K.R., Loeb L.A. Genetic instability and the mutator phenotype. Studies in ulcerative colitis. Am. J. Pathol. 1999, 154:1621-1626.
8. Bernstein C., Bernstein H., Payne C.M., Dvorak K., Garewal H. Field defects in progression to gastrointestinal tract cancers. Cancer Lett. 2008, 260:1-10.
9. Brentnall T.A., Crispin D.A., Rabinovitch P.S., Haggitt R.C., Rubin C.E., Stevens A.C., Burmer G.C. Mutations in the P53 gene - an early marker of neoplastic progression in ulcerative-colitis. Gastro 1994, 107:369-378.
10. Salk J.J., Salipante S.J., Risques R.A., Crispin D.A., Li L., Bronner M.P., Brentnall T.A., Rabinovitch P.S., Horwitz M.S., Loeb L.A. Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc. Natl. Acad. Sci. USA 2009, 106:20871-20876.
11. O'Sullivan J.N., Finley J.C., Risques R.A., Shen W.T., Gollahon K.A., Moskovitz A.H., Gryaznov S., Harley C.B., Rabinovitch P.S. Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms. Cytometry 2004, 58A:120-131.
12. Rabinovitch P.S., Dziadon S., Brentnall T.A., Emond M.J., Crispin D.A., Haggitt R.C., Bronner M.P. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res. 1999, 59:5148-5153.
13. Chen R., Rabinovitch P.S., Crispin D.A., Emond M.J., Koprowicz K.M., Bronner M.P., Brentnall T.A. DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free. Am. J. Pathol. 2003, 162:665-672.
14. Chen R., Bronner M.P., Crispin D.A., Rabinovitch P.S., Brentnall T.A. Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions. Cancer Genet. Cytogenet. 2005, 162:99-106.
15. Loo L.W.M., Grove D.I., Williams E.M., Neal C.L., Cousens L.A., Schubert E.L., Holcomb I.N., Massa H.F., Glogovac J., Li C.I., Malone K.E., Daling J.R., Delrow J.J., Trask B.J., Hsu L., Porter P.L. Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes. Cancer Res. 2004, 64:8541-8549.
16. Hsu L., Self S.G., Grove D., Randolph T., Wang K., Delrow J.J., Loo L., Porter P. Denoising array-based comparative genomic hybridization data using wavelets. Biostat 2005, 6:211-226.
17. Lai W., Choudhary V., Park P.J. CGHweb: a tool for comparing DNA copy number segmentations from multiple algorithms. Bioinformatics 2008, 24:1014-1015.
18. Muller A., Holzmann K., Kestler H.A. Visualization of genomic aberrations using affymetrix SNP arrays. Bioinformatics 2007, 23:496-497.
19. Diskin S.J., Eck T., Greshock J., Mosse Y.P., Naylor T., Stoeckert C.J., Weber B.L., Maris J.M., Grant G.R. STAC: a method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments. Genome Res. 2006, 16:1149-1158.
20. Risques R.A., Lai L.A., Himmetoglu C., Abaee A., Li L., Feng Z., Bronner M.P., Al-Lahham B., Kowdley K.V., Lindor K.D., Rabinovitch P.S., Brentnall T.A. Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence and inflammation. Cancer Res. 2011, 71:1669-1679.
21. Loeb L.A. A mutator phenotype in cancer. Cancer Res. 2001, 61:3230-3239.
22. Garcia S.B., Park H.S., Novelli M., Wright N.A. Field cancerization clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets. J. Pathol. 1999, 187:61-81.
23. Chen R., Rabinovitch P.S., Crispin D.A., Emond M.J., Bronner M.P., Brentnall T.A. The initiation of colon cancer in a chronic inflammatory setting. Carcinogenesis 2005, 26:1513-1519.
24. Garcia S.B., Novelli M., Wright N.A. The clonal origin and clonal evolution of epithelial tumours. Int. J. Exp. Pathol. 2000, 81:89-116.
25. Greaves L.C., Preston S.L., Tadrous P.J., Taylor R.W., Barron M.J., Oukrif D., Leedham S.J., Deheragoda M., Sasieni P., Novelli M.R., Jankowski J.A.Z., Turnbull D.M., Wright N.A., Mcdonald S.A.C. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc. Natl. Acad. Sci. USA 2006, 103714-103719.
26. Bronner M.P., Skacel M., Crispin D.A., Hoff P.D., Emond M.J., Lai L.A., Tubbs R.R., O'Sullivan J.N., Rabinovitch P.S., Brentnall T.A. Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors. Mod Path 2010, 23:1624-1633.
27. Hsieh S.Y., Shih T.C., Yeh C.Y., Lin C.J., Chou Y.Y., Lee Y.S. Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics 2006, 6:5322-5331.
28. Franke A., Hampe J., Rosenstiel P., Becker C., Wagner F., Hasler R., Little R.D., Huse K., Ruether A., Balschun T., Wittig M., ElSharawy A., Mayr G., Albrecht M., Prescott N.J., Onnie C.M., Fournier H., Keith T., Radelof U., Platzer M., Mathew C.G., Stoll M., Krawczak M., Nurnberg P., Schreiber S. Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS ONE 2007, 2:e691.
29. Wu F., Zikusoka M., Trindade A., Dassopoulos T., Harris M.L., Bayless T.M., Brant S.R., Chakravarti S., Kwon J.H. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastro 2008, 135:1624-1635.
30. Tuin A., Poelstra K., Jager-Krikken A., Bok L., Raaben W., Velders M.P., Dijkstra G. Role of alkaline phosphatase in colitis in man and rats. Gut 2009, 58:379-387.
31. Dincer Y., Erzin Y., Himmetoglu S., Gunes K.N., Bal K., Akcay T. Oxidative DNA damage and antioxidant activity in patients with inflammatory bowel disease. Dig. Dis. Sci. 2007, 52:1636-1641.
32. Stefansson T., Ekbom A., Sparen P., Pahlman L. Increased risk of left sided colon cancer in patients with diverticular-disease. Gut 1993, 34:499-502.
33. Stefansson T., Ekbom A., Sparen P., Pahlman L. Association between sigmoid diverticulitis and left-sided colon cancer: a nested, population-based, case control study. Scand. J. Gastro. 2004, 39:743-747.
34. Broome U., Bergquist A. Primary sclerosing cholangitis, inflammatory a bowel disease, and colon cancer. Sem. Liver Dis. 2006, 26:31-41.
35. Cheng K., Raufman J.P. Autocrine release of HB-EGF mediates bile acid-induced transactivation of colon cancer cell epidermal growth factor receptors (EGFR). Gastro 2005, 128:A613.
36. Raufman J.P., Shant J., Guo C.Y., Roy S., Cheng K. Deoxycholyltaurine rescues human coron cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling. J. Cell. Physiol. 2008, 215:538-549.