Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agents

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 4, 2012, Pages

  Chen, Guofang ^a   Xu, Shuhang ^a,c   Renko, Kostja ^b   Derwahl, Michael ^a  

^a St Hedwig Hospital   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN;

ANAPLASTIC CARCINOMA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL GROWTH; CELL RENEWAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GOITER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THYROID CARCINOMA; THYROID CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; GOITER, NODULAR; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN ANTAGONISTS; METFORMIN; NEOPLASTIC STEM CELLS; RATS; THYROID NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 84859526277     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1754     Document Type: Article

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