Toolbox for non-intrusive structural and functional analysis of recombinant VLP based vaccines: A case study with hepatitis B vaccine

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Mulder, Anke M ^b   Carragher, Bridget ^b   Towne, Victoria ^a   Meng, Yuan ^a   Wang, Yang ^a,c   Dieter, Lance ^a   Potter, Clinton S ^b   Washabaugh, Michael W ^a,d   Sitrin, Robert D ^a,e   Zhao, Qinjian ^a,f  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Vaccine Bioprocess R and D Merck Research Laboratories ^*  (United States)

^c Sino Biological Inc   (China)

^d MEDIMMUNE   (United States)

^e SitrinSolutions LLC   (United States)

^f XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; MONOCLONAL ANTIBODY; RECOMBINANT VACCINE; IMMUNOLOGICAL ADJUVANT; VIRUS LIKE PARTICLE VACCINE;

ANTIGENICITY; ARTICLE; ATOMIC FORCE MICROSCOPY; CASE STUDY; CRYOELECTRON MICROSCOPY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMAGE RECONSTRUCTION; IMMUNOREACTIVITY; PARTICLE SIZE; QUANTITATIVE ANALYSIS; SURFACE PLASMON RESONANCE; VIRUS LIKE AGENT; CHEMICAL STRUCTURE; CHEMISTRY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOLOGY; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE; VIROLOGY;

ADJUVANTS, IMMUNOLOGIC; ANTIBODIES, MONOCLONAL; CRYOELECTRON MICROSCOPY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HUMANS; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; PARTICLE SIZE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; VACCINES, SYNTHETIC; VACCINES, VIRUS-LIKE PARTICLE;

EID: 84859517390     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033235     Document Type: Article

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