Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation

Journal of Biological Chemistry

Volumn 287, Issue 14, 2012, Pages 10824-10833

  Sjölander, Jonatan ^a   Westermark, Gunilla T ^b   Renström, Erik ^a   Blom, Anna M ^a  

^a LUND UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BINDING ASSAYS; BINDING PROTEINS; COLOCALIZATION; COMPLEMENT CONTROL PROTEINS; COMPLEMENT SYSTEMS; CYTOTOXIC; DIABETIC PATIENT; FIBRIL FORMATION; HYDROPHOBIC BINDING; IMMUNOSTAINING; IN-VITRO; MEMBRANE ATTACK COMPLEXES; SPECIFIC INTERACTION;

CELL DEATH; GLYCOPROTEINS; OLIGOMERS; RECOMBINANT PROTEINS;

BIOSYNTHESIS;

AMYLIN; AMYLOID BETA PROTEIN; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C4B BINDING PROTEIN; COMPLEMENT CONTROL PROTEIN 2; COMPLEMENT CONTROL PROTEIN 8; COMPLEMENT FACTOR; COMPLEMENT FACTOR H; COMPLEMENT MEMBRANE ATTACK COMPLEX; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMYLOIDOSIS; ARTICLE; BINDING SITE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT DEPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; HISTOLOGY; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT;

AMYLOID; ANIMALS; COMPLEMENT C4B-BINDING PROTEIN; DIABETES MELLITUS, TYPE 2; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISLET AMYLOID POLYPEPTIDE; PANCREAS; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; RATS;

EID: 84859514014     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.244285     Document Type: Article

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