The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release

Microvascular Research

Volumn 83, Issue 3, 2012, Pages 347-351

  Forsyth, Alison M ^a,b   Braunmüller, Susanne ^c   Wan, Jiandi ^a   Franke, Thomas ^c   Stone, Howard A ^a  

^a Princeton University   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF AUGSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHOLESTEROL; SIMVASTATIN;

ARTICLE; CELL LEVEL; CELL MEMBRANE; CONTROLLED STUDY; DRUG ACTIVITY; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE VOLUME; HUMAN; HUMAN CELL; NUCLEOTIDE TRANSPORT; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANTICHOLESTEREMIC AGENTS; CELL SHAPE; CELL SIZE; CHOLESTEROL; ERYTHROCYTE COUNT; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HUMANS; MODELS, STATISTICAL; SIMVASTATIN;

ANGINA;

EID: 84859509670     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2012.02.004     Document Type: Article

References (36)

1. Amundson D.M., Zhou M. Fluorometric method for the enzymatic determination of cholesterol. J. Biochem. Biophys. Methods 1999, 38:43-52.
2. Banerjee R., Nageshwari K., Puniyani R.R. The diagnostic relevance of red cell rigidity. Clin. Hemorheol. Microcirc. 1998, 19:21-24.
3. Bhandary S., Basu R., Das S., Nandy P. Effect of some statin group of drugs on the phase profile of liposomal membrane - a fluorescence anisotropy study. Phase Transit. 2009, 82:821-830.
4. Braunstein G.M., Roman R.M., Clancy J.P., Kudlow B.A., Taylor A.L., Shylonsky V.G., Jovov B., Peter K., Jilling T., Ismailov I.I., Benos D.J., Schwiebert L.M., Fitz J.G., Schwiebert E.M. Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation. J. Biol. Chem. 2001, 276:6621-6630.
5. Caliskan S., Caliskan M., Kuralay F., Onvural B. Effect of simvastatin therapy on blood and tissue ATP levels and erythrocyte membrane lipid composition. Res. Exp. Med. (Berl.) 2000, 199:189-194.
6. Cassera M.B., Silber A.M., Gennaro A.M. Differential effects of cholesterol on acyl chain order in erythrocyte membranes as a function of depth from the surface. An electron paramagnetic resonance (EPR) spin label study. Biophys. Chem. 2002, 99:117-127.
7. Chabanel A., Flamm M., Sung K.L., Lee M.M., Schachter D., Chien S. Influence of cholesterol content on red cell membrane viscoelasticity and fluidity. Biophys. J. 1983, 44:171-176.
8. Christian A.E., Haynes M.P., Phillips M.C., Rothblat G.H. Use of cyclodextrins for manipulating cellular cholesterol content. J. Lipid Res. 1997, 38:2264-2272.
9. Evans E.A. Structure and deformation properties of red blood cells: concepts and quantitative methods. Methods Enzymol. 1989, 173:3-35.
10. Ellsworth M.L., Ellis C.G., Goldman D., Stephenson A.H., Dietrich H.H., Sprague R.S. Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology 2009, 24:107-116.
11. Farias M., Gorman M.W., Savage M.V., Feigl E.O. Plasma ATP during exercise: possible role in regulation of coronary blood flow. Am. J. Physiol. Heart Circ. Physiol. 2005, 288:H1586-H1590.
12. Forsyth A.M., Wan J., Owrutsky P.D., Abkarian M., Stone H.A. Multiscale approach to link red blood cell dynamics, shear viscosity, and ATP release. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:10986-10991.
13. Forsyth A.M., Wan J., Ristenpart W.D., Stone H.A. The dynamic behavior of chemically "stiffened" red blood cells in microchannel flows. Microvasc. Res. 2010, 80:37-43.
14. Hochmuth R.M., Waugh R.E. Erythrocyte membrane elasticity and viscosity. Annu. Rev. Physiol. 1987, 49:209-219.
15. Kohno M., Murakawa K., Yasunari K., Yokokawa K., Horio T., Kano H., Minami M., Yoshikawa J. Improvement of erythrocyte deformability by cholesterol-lowering therapy with pravastatin in hypercholesterolemic patients. Metabolism 1997, 46:287-291.
16. Kolodgie F.D., Burke A.P., Nakazawa G., Cheng Q., Xu X., Virmani R. Free cholesterol in atherosclerotic plaques: where does it come from?. Curr. Opin. Lipidol. 2007, 18:500-507.
17. Kolovou G.D., Katerina A., Ioannis V., Cokkinos D.V. Simvastatin: two decades in a circle. Cardiovasc. Ther. 2008, 26:166-178.
18. Lange Y., Ye J., Steck T.L. How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:11664-11667.
19. Lange Y., Ye J., Steck T.L. Scrambling of phospholipids activates red cell membrane cholesterol. Biochemistry 2007, 46:2233-2238.
20. Levitan I., Christian A.E., Tulenko T.N., Rothblat G.H. Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells. J. Gen. Physiol. 2000, 115:405-416.
21. Maxfield F.R., Tabas I. Role of cholesterol and lipid organization in disease. Nature 2005, 438:612-621.
22. Meleard P., Gerbeaud C., Pott T., Fernandez-Puente L., Bivas I., Mitov M.D., Dufourcq J., Bothorel P. Bending elasticities of model membranes: influences of temperature and sterol content. Biophys. J. 1997, 72:2616-2629.
23. Mouritsen O.G., Zuckermann M.J. What's so special about cholesterol?. Lipids 2004, 39:1101-1113.
24. Munro S. Lipid Rafts. Cell 2003, 115:377-388.
25. Radhakrishnan A., Anderson T.G., McConnell H.M. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:12422-12427.
26. Rose H.G., Oklander M. Improved procedure for the extraction of lipids from human erythrocytes. J. Lipid Res. 1965, 6:428-431.
27. Simons K., Ikonen E. Functional rafts in cell membranes. Nature 1997, 387:569-572.
28. Sprague R., Ellsworth M.L., Stephenson A.H., Kleinhenz M.E., Lonigro A.J. Deformation-induced ATP release from red blood cells requires CFTR activity. Am. J. Physiol. Heart Circ. Physiol. 1998, 275:H1726-H1732.
29. Sprague R.S., Stephenson A.H., Dimmitt R.A., Weintraub N.L., Branch C.A., Mcmurdo L., Lonigro A.J. Effect of L-NAME on pressure-flow relationships in isolated rabbit lungs: role of red blood cells. Am. J. Physiol. 1995, 269:H1941-H1948.
30. Stone H.A. Introduction to fluid dynamics for microfluidic flows. CMOS Biotechnology 2007, 5-30. Springer, US. H. Lee, R.M. Westervelt, D. Ham (Eds.).
31. Subasinghe W., Spence D.M. Simultaneous determination of cell aging and ATP release from erythrocytes and its implications in type 2 diabetes. Anal. Chim. Acta 2008, 618:227-233.
32. Tziakas D.N., Chalikias G.K., Stakos D., Tentes I.K., Thomaidi A., Chatzikyriakou S., Mitrousi K., Kortsaris A.X., Kaski J.C., Boudoulas H., Konstantinides S. Statin use is associated with a significant reduction in cholesterol content of erythrocyte membranes. A novel pleiotropic effect?. Cardiovasc. Drugs Ther. 2009, 23:471-480.
33. Tziakas D.N., Kaski J.C., Chalikias G.K., Romero C., Fredericks S., Tentes I.K., Kortsaris A.X., Hatseras D.I., Holt D.W. Total cholesterol content of erythrocyte membranes is increased in patients with acute coronary syndrome: a new marker of clinical instability?. J. Am. Coll. Cardiol. 2007, 49:2081-2089.
34. Vaya A., Martinez Triguero M., Reganon E., Vila V., Martinez Sales V., Sola E., Hernandez Mijares A., Ricart A. Erythrocyte membrane composition in patients with primary hypercholesterolemia. Clin. Hemorheol. Microcirc. 2008, 40:289-294.
35. Vennemann P., Lindken R., Westerweel J. In vivo whole-field blood velocity measurement techniques. Exp. Fluids 2007, 42:495-511.
36. Wan J., Ristenpart W.D., Stone H.A. Dynamics of shear-induced ATP release from red blood cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:16432-16437.