Cholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashion

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Breen, Michael R ^a   Camps, Marta ^b,c   Carvalho Simoes, Francisco ^b,c   Zorzano, Antonio ^b,c,d   Pilch, Paul F ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CAVIN 1; CAVIN 2; CELL PROTEIN; CHOLESTEROL; MEMBRANE PROTEIN; PROTEASOME; UNCLASSIFIED DRUG; BETA CYCLODEXTRIN DERIVATIVE; CAVIN PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPROTEIN; METHYL BETA CYCLODEXTRIN; METHYL-BETA-CYCLODEXTRIN; SMALL INTERFERING RNA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CAVEOLA; CELL MEMBRANE; CELL STRAIN 3T3; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; ANIMAL; CELL STRAIN HEK293; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENE VECTOR; GENETICS; HUMAN; LENTIVIRINAE; METABOLISM; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BETA-CYCLODEXTRINS; CAVEOLAE; CHOLESTEROL; FIBROBLASTS; GENETIC VECTORS; HEK293 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LENTIVIRUS; MEMBRANE PROTEINS; MICE; PRIMARY CELL CULTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN ISOFORMS; PROTEIN TRANSPORT; PROTEOLYSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84859508881     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034516     Document Type: Article

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