HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function

Journal of Biological Chemistry

Volumn 287, Issue 14, 2012, Pages 11030-11036

  Nobumori, Yumiko ^a   Shouse, Geoffrey P ^a   Fan, Li ^a   Liu, Xuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SUBUNITS; DEPHOSPHORYLATIONS; DNA DAMAGES; PROTEIN PHOSPHATASE 2A; REGULATORY SUBUNITS; STRUCTURAL INSIGHTS; TRANSCRIPTIONAL TARGETS;

CELL PROLIFERATION;

TUMORS;

HOLOENZYME; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2A B56 GAMMA SUBUNIT; PHOSPHOPROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT; PHOSPHOPROTEIN PHOSPHATASE 2A SCAFFOLDING SUBUNIT; PROTEIN P53; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HCT116; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVE SITE; ENZYME INACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HUNTINGTON ELONGATION A SUBUNIT TOR REPEAT 1 MOTIF; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; SCAFFOLDING SUBUNIT; TRANSCRIPTION INITIATION;

AMINO ACID MOTIFS; HCT116 CELLS; HOLOENZYMES; HUMANS; MODELS, MOLECULAR; PROTEIN PHOSPHATASE 2; PROTEIN SUBUNITS; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEINS;

EID: 84859506063     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334094     Document Type: Article

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