Seizure activity in dogs is associated with enhanced TIMP-2 expression of microglia

Veterinary Immunology and Immunopathology

Volumn 146, Issue 2, 2012, Pages 101-105

  Stein, Veronika M ^a   Genini, Sem ^b   Puff, Christina ^a   Baumgärtner, Wolfgang ^a,c   Tipold, Andrea ^a,c  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Centre for Systems Neuroscience   (Germany)

Author keywords

Epilepsy; Microglia; MMP; TIMP

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CEREBROVASCULAR DISEASE; DENSITY GRADIENT CENTRIFUGATION; DOG; EPILEPTOGENESIS; GENE EXPRESSION PROFILING; MICROGLIA; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEIZURE; UPREGULATION;

ANIMALS; DOG DISEASES; DOGS; MATRIX METALLOPROTEINASES; MICROGLIA; NEURONAL PLASTICITY; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SEIZURES; STATISTICS, NONPARAMETRIC; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

CANIS FAMILIARIS;

EID: 84859482034     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2012.02.003     Document Type: Article

References (21)

1. Agrawal S.M., Lau L., Yong V.W. MMPs in the central nervous system: where the good guys go bad. Semin. Cell Dev. Biol. 2008, 19:42-51.
2. Ben-Ari Y. Cell death and synaptic reorganizations produced by seizures. Epilepsia 2001, 42(Suppl. 3):5-7.
3. Berendt M. Epilepsy. Clinical Neurology in Small Animals: Localization, Diagnosis and Treatment 2004, International Veterinary Information Service, Ithaca. http://www.ivis.org/, C.H. Vite (Ed.).
4. Celio M.R., Blümcke I. Perineuronal nets-a specialized form of extracellular matrix in the adult nervous system. Brain Res. Brain Res. Rev. 1994, 19:128-145.
5. Cuzner M.L., Gveric D., Strand C., Loughlin A.J., Paemen L., Opdenakker G., Newcombe J. The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous inhibitors in the central nervous system in multiple sclerosis: comparison of stages in lesion evolution. J. Neuropathol. Exp. Neurol. 1996, 55:1194-1204.
6. De Haas A.H., Boddeke H.W.G.M., Biber K. Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS. Glia 2008, 56(8):888-894.
7. Ensinger E.M., Boekhoff T.M., Carlson R., Beineke A., Rohn K., Tipold A., Stein V.M. Regional topographical differences of canine microglial immunophenotype and function in the spinal cord. J Neuroimmunol 2010, 227:144-152.
8. Ebert U., Schwabe K., Loscher W. Glia cells influence limbic epileptogenesis in the piriform cortex of the rat. Göttingen Neurobiology Report 1999 1999, 772. Thieme, Stuttgart. N. Elsner, U. Eysel (Eds.).
9. Engel J. Epilepsy: structural or functional?. Am. J. Neuroradiol. 1996, 17:243-244.
10. Giulian D. Microglia and disease of the nervous system. Curr. Top. Neurol. 1992, 12:23-24.
11. Gottschall P.E., Deb S. Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation 1996, 3:69-75.
12. Gröters S., Alldinger S., Baumgärtner W. Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis. Acta Neuropathol. 2005, 110:369-382.
13. Jaworski J., Biedermann I.W., Lapinska J., Szklarczyk A., Figiel I., Konopka D., Nowicka D., Filipkowski R.K., Hetman M., Kowalczyk A., Kaczmarek L. Neuronal excitation-driven and AP-1-dependent activation of tissue inhibitor of metalloproteinases-1 gene expression in rodent hippocampus. J. Biol. Chem. 1999, 274:28106-28112.
14. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
15. Löscher W. Animal models of intractable epilepsy. Prog. Neurobiol. 1997, 53:239-258.
16. Nedivi E., Hevroni D., Naot D., Israeli D., Citri Y. Numerous candidate plasticity-related genes revealed by differential cDNA cloning. Nature 1993, 363:718-722.
17. Pitkänen A., Sutula T.P. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol. 2002, 1:173-181.
18. Stein V.M., Puff C., Genini S., Bono Contioso V., Baumgärtner W., Tipold A. Variations on brain microglial gene expression of MMPs, RECK, and TIMPs in inflammatory and non-inflammatory diseases in dogs. Vet. Immunol. Immunopathol. 2011, 144:17-26.
19. Takács E., Nyilas R., Szepesi Z., Baracskay P., Karlsen B., Røsvold T., Bjørkum A.A., Czurkó A., Kovács Z., Kékesi A.K., Juhász G. Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: a possible role in homeostatic synaptic plasticity. Neurochem. Int. 2010, 56:799-809.
20. Wilczynski G.M., Konopacki F.A., Wilczek E., Lasiecka Z., Gorlewicz A., Michaluk P., Wawrzyniak M., Malinowska M., Okulski P., Kolodziej L.R., Konopka W., Duniec K., Mioduszewska B., Nikolaev E., Walczak A., Owczarek D., Gorecki D.C., Zuschratter W., Ottersen O.P., Kaczmarek L. Important role of matrix metalloproteinase 9 in epileptogenesis. J. Cell Biol. 2008, 180:1021-1035.
21. Yong V.W., Power C., Forsyth P., Edwards D.R. Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci. 2001, 2:502-511.