Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer

Oncology Letters

Volumn 3, Issue 6, 2012, Pages 1207-1212

  Lu, Zhenhui ^a   Zhang, Yong ^b   Li, Zhaoyu ^a   Yu, Songning ^a   Zhao, Guozhong ^a   Li, Minghao ^a   Wang, Zuozhen ^a   Wang, Qi ^a   Yang, Yinxue ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

B type Eph; Ephrin; Human pancreatic cancer

Indexed keywords

EPHRIN; EPHRIN RECEPTOR B2; MESSENGER RNA;

ADULT; ARTICLE; BACKACHE; BLOOD CELL COUNT; CANCER GROWTH; CANCER PAIN; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; GENE OVEREXPRESSION; HISTOLOGY; HUMAN; LIVER FUNCTION TEST; LYMPH NODE METASTASIS; MALE; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PANCREAS CANCER; PHENOTYPE; THORAX RADIOGRAPHY; TUMOR DIFFERENTIATION;

EID: 84859464720     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.650     Document Type: Article

References (19)

1. Coulthard MG, Duffy S, Down M, Evans B, Power M, Smith F, Stylianou C, Kleikamp S, Oates A, Lackmann M, Burns GF and Boyd AW: The role of the Eph-ephrin signalling system in the regulation of developmental patterning. Int J Dev Biol 46: 375-384, 2002.
2. Klein R: Bidirectional signals establish boundaries. Curr Biol 9: R691-R694, 1991.
3. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DJ, Pawson T, Davis S and Yancoupoulos GD: Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalised during embryogenesis. Neuron 17: 9-19, 1996.
4. Boyd AW and Lackmann M: Signals from Eph and ephrin proteins: a developmental tool kit. Sci STKE 112: re20, 2001.
5. Hirai H, Maru Y, Hagiwara K, Nishida J and Takaku F: A novel putative tyrosine kinase receptor encoded by the eph gene. Science 238: 1717-1720, 1987.
6. Batlle E, Henderson JT, Beghtel H, van den Bron MM, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T and Clevers H: Beta-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrin B. Cell 111: 251-263, 2002.
7. Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S and Clevers H: EphB receptor activity suppresses colorectal cancer progression. Nature 435: 1126-1130, 2005.
8. Kataoka H, Tanaka M, Kanamori M, Yoshii S, Ihara M, Wang YJ, Song JP, Li ZY, Arai H, Otsuki Y, Kobayashi T, Konno H, Hanai H and Sugimura H: Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. J Cancer Res Clin Oncol 28: 343-348, 2002.
9. Stephenson SA, Slomka S, Douglas EL, Hewett PJ and Hardingham JE: Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer. Int J Dev Biol 46: 375-384, 2002.
10. Berclaz G, Flutsch B, Altermatt HJ, Rohrback H, Djonov V, Ziemiecki A, Dreher E and Andres AC: Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast. Pain 139: 168-180, 2008.
11. Nikolova Z, Djonov V, Zuercher G, Andres AC and Ziemiecki A: Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin B2 during mammary gland morphogenesis. J Cell Sci 111: 2741-2751, 1998.
12. Liu W, Ahmad SA, Jung YD, Reinmuth N, Fan F, Bucana CD and Ellis LM: Co-expression of ephrin-Bs and their receptors in colon carcinoma. Cancer 94: 934-939, 2002.
13. Zhang Y, Dang C, Ma Q and Shimahara Y: Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer. Oncol Rep 14: 161-171, 2005.
14. Holmberg J and Frisen J: Ephrins are not only unattractive. Trends Neurosci 25: 239-243, 2002.
15. Kobayashi H, Kitamura T, Sekiguchi M, Homma MK, Kabuyama Y, Konno S, Kikuchi S and Homma Y: Involvement of EphB1 receptor/EphrinB2 ligand in neuropathic pain. Spine (Phila Pa 1976) 32: 1592-1598, 2007.
16. Song XJ, Zheng JH, Cao JL, Liu WT, Song XS and Huang ZJ: EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats. Pain 139: 168-180, 2008.
17. Mao W, Luis E, Ross S, Silva J, Tan C, Crowley C, Chui C, Franz G, Senter P, Koeppen H and Polakis P: EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer. Cancer Res 64: 781-788, 2004.
18. Toledo-Sherman L, Deretey E, Slon-Usakiewicz JJ, Ng W, Dai JR, Foster JE, Redden PR, Uger MD, Liao LC, Pasternak A and Reid N: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. J Med Chem 48: 3221-3230, 2005.
19. Koolpe M, Burgess R, Dail M and Pasquale EB: EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem 280: 17301-17311, 2005.