Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2564-2571

  Matsuya, Yuji ^a   Ihara, Daisuke ^a   Fukuchi, Mamoru ^a   Honma, Daisuke ^a   Itoh, Kiyoshi ^a   Tabuchi, Akiko ^a   Nemoto, Hideo ^a   Tsuda, Masaaki ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

BDNF; Deltamethrin; Ethynyl substituent; Pyrethroid; Structure activity relationship

Indexed keywords

1 (1 HYDROXY 2 PROPYNYL) 3 PHENOXYBENZENE; 1 (1 HYDROXY 3 IODO 2 PROPYNYL) 3 PHENOXYBENZENE; 1 (1 TERT BUTYLDIMETHYLSILYLOXY 2 PROPYNYL) 3 PHENOXYBENZENE; 1 (3 BROMO 1 HYDROXY 2 PROPYNYL) 3 PHENOXYBENZENE; 1 (3 PHENOXYPHENYL) 2 PROPYNYL 2 (2,2 DIBROMOETHENYL) 3,3 DIMETHYLCYCLOPROPANECARBOXYLIC ACID; 1 PHENOXY 3 (3 TRIMETHYLSILYL 1 HYDROXY 2 PROPYNYL)BENZENE; 1 PHENOXY 3 (3 TRIMETHYLSILYL 2 PROPYNOYL)BENZENE; BRAIN DERIVED NEUROTROPHIC FACTOR; DELTAMETHRIN; MESSENGER RNA; PYRETHROID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BDNF GENE; BRAIN NERVE CELL; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EVOKED RESPONSE; EXON; GENE; GENE EXPRESSION; GENE INDUCTION; GENE LOCATION; MORPHOLOGICAL TRAIT; NONHUMAN; RAT; SUBSTITUTION REACTION; SYNTHESIS;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; INSECTICIDES; MOLECULAR CONFORMATION; NEURONS; PYRETHRINS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

HEXAPODA; RATTUS;

EID: 84859431793     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.048     Document Type: Article

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