Sublingual immunization with an engineered Bacillus subtilis strain expressing tetanus toxin fragment C induces systemic and mucosal immune responses in piglets

Microbes and Infection

Volumn 14, Issue 5, 2012, Pages 447-456

  Amuguni, Hellen ^a   Lee, Sangun ^a   Kerstein, Kathryn ^b   Brown, David ^a   Belitsky, Boris ^b   Herrmann, John ^a   Keusch, Gerald ^c   Sonenshein, Abraham ^b   Tzipori, Saul ^a  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

B. subtilis bacteria; Intranasal immunization; Piglets; Sublingual immunization; Tetanus vaccine

Indexed keywords

BACILLUS SUBTILIS BASED TETANUS VACCINE; DIPHTHERIA PERTUSSIS TETANUS VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUTRALIZING ANTIBODY; RECOMBINANT TETANUS TOXIN FRAGMENT C; TETANUS TOXIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC ENGINEERING; IMMUNE RESPONSE; MUCOSAL IMMUNITY; NONHUMAN; PIGLET; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SALIVA; TH1 TH2 BALANCE; VAGINA;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADMINISTRATION, SUBLINGUAL; ANIMALS; ANTIBODIES, BACTERIAL; BACILLUS SUBTILIS; BACTERIAL VACCINES; BODILY SECRETIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; MICE; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS; SERUM; SWINE; TETANUS TOXIN; TETANUS TOXOID; TH1 CELLS; TH2 CELLS; VACCINES, SYNTHETIC;

BACILLUS SUBTILIS; MUS;

EID: 84859428585     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2011.12.001     Document Type: Article

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