VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: Evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model

Inflammation

Volumn 35, Issue 1, 2012, Pages 39-48

  Spang, Christoph ^a   Scott, Alexander ^b,c   Danielson, Patrik ^a   Lorentzon, Ronny ^a   Forsgren, Sture ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c VANCOUVER COASTAL HEALTH   (Canada)

Author keywords

Glutamate; Inflammation; NMDAR1; Soleus muscle; VGluT2

Indexed keywords

BIOLOGICAL MARKER; EOSINOPHIL PEROXIDASE; GLUTAMIC ACID; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; VESICULAR GLUTAMATE TRANSPORTER 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; GENE; GENE EXPRESSION REGULATION; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATORY INFILTRATE; INTRACELLULAR SIGNALING; MYOSITIS; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; RABBIT; REPETITIVE STRAIN INJURY; SOLEUS MUSCLE; VESICULAR GLUTAMATE TRANSPORTER 2 GENE;

ANIMALS; AUTOCRINE COMMUNICATION; CUMULATIVE TRAUMA DISORDERS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EOSINOPHIL PEROXIDASE; FEMALE; GLUTAMIC ACID; MUSCLE, SKELETAL; MYOSITIS; PARACRINE COMMUNICATION; RABBITS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SIGNAL TRANSDUCTION; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2;

ORYCTOLAGUS CUNICULUS;

EID: 84859426270     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-010-9287-z     Document Type: Article

References (26)

1. Barbe, M.F., and A.E. Barr. 2006. Inflammation and the pathophysiology of work-related musculoskeletal disorders. Brain, Behavior, and Immunity 20: 423-429. (Pubitemid 44175798)
2. Barr, A.E., and M.F. Barbe. 2002. Pathophysiological tissue changes associated with repetitive movement: a review of the evidence. Physical Therapy 82: 173-187. (Pubitemid 34113003)
3. Van Tulder, M., A. Malmivaara, and B. Koes. 2007. Repetitive strain injury. Lancet 369: 1815-1822. (Pubitemid 46783021)
4. Barr, A.E., M.F. Barbe, and B.D. Clark. 2004. Systemic inflammatory mediators contribute to widespread effects in work-related musculoskeletal disorders. Exercise and Sport Sciences Reviews 32: 135-142. (Pubitemid 39362876)
5. Barbe, M.F., A.E. Barr, I. Gorzelany, M. Amin, J.P. Gaughan, and F.F. Safadi. 2003. Chronic repetitive reaching and grasping results in decreased motor performance and widespread tissue responses in a rat model of MSD. Journal of Orthopaedic Research 21: 167-176. (Pubitemid 36157634)
6. Fedorczyk, J.M., A.E. Barr, S. Rani, H.G. Gao, M. Amin, S. Amin, J. Litvin, and M.F. Barbe. 2010. Exposure-dependent increases in il-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. Journal of Orthopaedic Research 28: 298-307.
7. Flodgren, G.M., A.G. Crenshaw, H. Alfredson, M. Fahlström, F.B. Hellström, L. Bronemo, and M. Djupsjöbacka. 2005. Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis. European Journal of Pain 9: 511-515. (Pubitemid 41219783)
8. Alfredson, H., and R. Lorentzon. 2003. Intratendinous glutamate levels and eccentric training in chronic Achilles tendinosis: a prospective study using microdialysis technique. Knee Surgery, Sports Traumatology, Arthroscopy 11: 196-199. (Pubitemid 38249647)
9. Scott, A., H. Alfredson, and S. Forsgren. 2008. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. Journal of Orthopaedic Research 26: 685-692.
10. Cairns, B.E., J.W. Hu, L. Arendt-Nielsen, B.J. Sessle, and P. Svensson. 2001. Sex-related differences in human pain and rat afferent discharge evoked by injection of glutamate into the masseter muscle. Journal of Neurophysiology 86: 782-791. (Pubitemid 32738567)
11. Petrenko, A.B., T. Yamakura, H. Baba, and K. Shimoji. 2003. The role of n-methyl-d-aspartate (NMDA) receptors in pain: a review. Anesthesia and Analgesia 97: 1108-1116. (Pubitemid 37158698)
12. DeGroot, J., S. Zhou, and S.M. Carlton. 2000. Peripheral glutamate release in the hindpaw following low and high intensity sciatic stimulation. NeuroReport 11: 497-502. (Pubitemid 30120464)
13. McAdoo, D.J., M.G. Hughes, G.Y. Xu, G. Robak, and R. de Castro Jr. 1997. Microdialysis studies of the role of chemical agents in secondary damage upon spinal cord injury. Journal of Neurotrauma 14: 507-515. (Pubitemid 27377659)
14. Boldyrev, A.A., V.I. Kazey, T.A. Leinsoo, A.P. Mashkina, O.V. Tyulina, P. Johnson, J.O. Tuneya, S. Chittur, and D.O. Carpenter. 2004. Rodent lymphocytes express functionally active glutamate receptors. Biochemical and Biophysical Research Communications 324: 133-139. (Pubitemid 39311470)
15. Backman, C., L. Boquist, J. Friden, R. Lorentzon, and G. Toolanen. 1990. Chronic Achilles paratenonitis with tendinosis: an experimental model in the rabbit. Journal of Orthopaedic Research 8: 541-547. (Pubitemid 20319510)
16. Backman, C., J. Friden, and A. Widmark. 1991. Blood flow in chronic Achilles tendinosis. Radioactive microsphere study in rabbits. Acta Orthopaedica Scandinavica 62: 386-387.
17. Andersson, G., Forsgren, S., Scott, A., Gaida, J.E., Elgestad Stjernfeldt, J., Lorentzon, R., Alfredson, H., Backman, C., and Danielson, P. 2010. Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms. British Journal of Sports Medicine. doi:10.1136/bjsm.2009.068122.
18. Hansson, M., and S. Forsgren. 1995. Immunoreactive atrial and brain natriuretic peptides are co-localized in Purkinje fibers but not in the innervation of the bovine heart conduction system. The Histochemical Journal 27: 222-230.
19. Tong, Q., J. Ma, and A.L. Kirchgessner. 2001. Vesicular glutamate transporter 2 in the brain-gut axis. NeuroReport 12: 3929-3934. (Pubitemid 33152427)
20. Panoskaltsis-Mortari, A., and R.P. Bucy. 1995. In situ hybridization with digoxigenin-labeled RNA probes: facts and artifacts. Biotechniques 18: 300-307.
21. Collard, C.D., K.A. Park, M.C. Montalto, S. Alapati, J.A. Buras, G.L. Stahl, and S.P. Colgan. 2002. Neutrophil-derived glutamate regulates vascular endothelial barrier function. The Journal of Biological Chemistry 277: 14801-14811. (Pubitemid 34952552)
22. Leo, S., D. Moechars, Z. Callaerts-Vegh, R. D'Hooge, and T. Meert. 2009. Impairment of VGluT2 but not VGluT1 signaling reduces neuropathy-induced hypersensitivity. European Journal of Pain 13: 1008-1017.
23. Miglio, G., F. Varsaldi, C. Dianzani, R. Fantozzi, and G. Lombardi. 2005. Stimulation of group in metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells. Biochemical Pharmacology 70: 189-199. (Pubitemid 40814401)
24. Tuneva, E.O., O.N. Bychkova, and A.A. Boldyrev. 2003. Effect of NMDA on production of reactive oxygen species by human lymphocytes. Bulletin of Experimental Biology and Medicine 136: 159-161. (Pubitemid 38132982)
25. Scott, A., K.M. Khan, C.R. Roberts, J.L. Cook, and V. Duronio. 2004. What do we mean by the term "inflammation"? A contemporary basic science update for sports medicine. British Journal of Sports Medicine 38: 372-380. (Pubitemid 38748147)
26. MacIntyre, D.L., W.D. Reid, D.M. Lyster, I.J. Szasz, and D.C. McKenzie. 1996. Presence of wbc, decreased strength, and delayed soreness in muscle after eccentric exercise. Journal of Applied Physiology 80: 1006-1013. (Pubitemid 26087269)