Use of supercritical CO 2-aided and conventional melt extrusion for enhancing the dissolution rate of an active pharmaceutical ingredient

Polymers for Advanced Technologies

Volumn 23, Issue 5, 2012, Pages 909-918

  Nagy, Zsombor Kristóf ^a   Sauceau, Martial ^b   Nyúl, Katalin ^a   Rodier, Elisabeth ^b   Vajna, Balázs ^a   Marosi, György ^a   Fages, Jacques ^b  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Amorphization; Enhanced drug dissolution rate; Extrusion; Solid dispersion; Solid solution; Supercritical CO 2 extrusion

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; CARVEDILOL; DISSOLUTION RATES; DRUG DISSOLUTION; EUDRAGIT; EXTRUSION PROCESS; FOURIER TRANSFORM INFRARED SPECTROMETRY; MELT EXTRUSION; MELT VISCOSITIES; MOLECULAR LEVELS; PHARMACEUTICAL FORMULATION; PHARMACEUTICAL INDUSTRY; PLASTICIZING EFFECTS; POLYACRYLATE MATRIX; POORLY SOLUBLE DRUGS; PROCESSABILITY; PROCESSING TEMPERATURE; RAMAN MAPPING; RESIDENCE TIME; SOLID DISPERSION; SUPER-CRITICAL; SUPERCRITICAL CO;

AMORPHIZATION; BIOCHEMISTRY; CAPILLARY ELECTROPHORESIS; CARBON DIOXIDE; DISPERSIONS; DRUG PRODUCTS; EXTRUSION; EXTRUSION DIES; FOURIER TRANSFORM INFRARED SPECTROSCOPY; SOLID SOLUTIONS; X RAY DIFFRACTION;

MELT SPINNING;

EID: 84859423892     PISSN: 10427147     EISSN: 10991581     Source Type: Journal    
DOI: 10.1002/pat.1991     Document Type: Article

References (24)

1. C. Rauwendaal, Polymer Extrusion. Hanser Publishers, Munich, Germany, 2001.
2. J. Breitenbach, Eur. J. Pharm. Biopharm. 2002, 54, 107-117.
3. J. W. McGinity, M. A. Repka, J. J. Koleng, F. Zhang, Hot-melt Extrusion Technology, Encyclopedia of Pharmaceutical Technology (3rd Ed). Informa healthcare, New York, London, 2007, 2004-2020.
4. M. Sauceau, D. Ponomarev, C. Nikitine, E. Rodier, J. Fages, Supercritical Fluid and Materials. INPL, Vandoeuvre, France, 2007, 217-237.
5. M. Dittgen, M. Durrani, K. Lehmann, STP Pharma. Sci. 1997, 7, 403-437.
6. R. C. Rowe, P. J. Sheskey, P. J. Weller, Handbook of Pharmaceutical Excipients. Pharmaceutical Press, London, UK, 2006.
7. K. Six, G. Verreck, J. Peeters, M. Brewster, G. V. Mooter, J. Pharm. Sci. 2004, 93, 124-131.
8. G. Verreck, A. Decorte, H. Li, D. Tomasko, A. Arien, J. Peeters, P. Rombaut, G. Van den Mooter, M. E. Brewster, J. Supercrit. Fluids 2006, 38, 383-391.
9. C. Nikitine, E. Rodier, M. Sauceau, J. J. Letourneau, J. Fages, J. Appl. Polym. Sci. 2010, 115, 981-990.
10. C. Nikitine, E. Rodier, M. Sauceau, J. Fages, Chem. Eng. Res. Des. 2009, 87, 809-816.
11. D. Ponomarev, M. Sauceau, C. Nikitine, E. Rodier, J. Fages, Proceedings of the 11th European Meeting on Supercritical Fluids, Barcelona (Spain), 2008.
12. M. Sauceau, J. Fages, A. Common, C. Nikitine, E. Rodier, Prog. Polym. Sci. 2011, in press. doi:10.1016/j.progpolymsci.2010.12.004.
13. P. C. Stafylas, P. A. Sarafidis, Vasc. Health Risk Manage. 2008, 4, 23.
14. T. Loftsson, S. B. Vogensen, C. Desbos, P. Jansook, AAPS PharmSciTech 2008, 9, 425-430.
15. S. Kalimuthu, A. Yadav, Int. J. Pharm. Tech. Res. 2009, 1, 179-183.
16. U. Ubaidulla, M. V. S. Reddy, K. Ruckmani, F. J. Ahmad, R. K. Khar, AAPS PharmSciTech 2007, 8, 13-20.
17. C. Nikitine, M. Sauceau, F. Léonardi, E. Rodier, J. Fages. Mesures rheologiques sur un biopolymere, 42 ème Colloque du Groupe Français de Rhéologie, Clermont-Ferrand, France, 2007.
18. P. Beyer, E. Reinholz, EP 0 893 440 A1, 1999.
19. J. Aronhime, S. Ben-Valid, B. Dolitzky, S. Finogueev, J. Hildesheim, WO 02/00216 A1, 2002.
20. V. B. Pokharkar, L. P. Mandpe, M. N. Padamwar, A. A. Ambike, K. R. Mahadik, A. Paradkar, Powder Technol. 2006, 167, 20-25.
21. G. Verreck, A. Decorte, K. Heymans, J. Adriaensen, D. Cleeren, A. Jacobs, D. Liu, D. Tomasko, A. Arien, J. Peeters, Eur. J. Pharm. Sci. 2005, 26, 349-358.
22. B. Vajna, I. Farkas, A. Szabó, Z. Zsigmond, G. Marosi, J. Pharm. Biomed. Anal. 2010, 51, 30-38.
23. U.S. Pharmacopeia, USP-NF General Chapter <905> Uniformity of Dosage Units 2007.
24. A. A. Noyes, W. R. Whitney, J. Am. Chem. Soc. 1897, 19, 930-934.