The effect of pressurized carbon dioxide as a plasticizer and foaming agent on the hot melt extrusion process and extrudate properties of pharmaceutical polymers

Journal of Supercritical Fluids

Volumn 38, Issue 3, 2006, Pages 383-391

  Verreck, Geert ^a   Decorte, Annelies ^a   Li, Hongbo ^b   Tomasko, David ^b   Arien, Albertina ^a   Peeters, Jef ^a   Rombaut, Patrick ^c   Van den Mooter, Guy ^c   Brewster, Marcus E ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Ohio State University   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Carbon dioxide; Hot melt extrusion; Pharmaceutical polymers; Pressurized gas; Solid dispersion; Supercritical

Indexed keywords

HOT MELT EXTRUSION; PHARMACEUTICAL POLYMERS; PRESSURIZED GAS; SOLID DISPERSION;

BLOWING AGENTS; COMMINUTION; METAL EXTRUSION; PHYSICAL CHEMISTRY; PLASTICIZERS; POLYMERS; POROSITY;

CARBON DIOXIDE;

EID: 33749461164     PISSN: 08968446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.supflu.2005.11.022     Document Type: Article

References (33)

1. El-Egakey M.A., Soliva M., and Speiser P. Hot extruded dosage forms. Pharm. Acta Helv. 46 (1971) 31
2. Breitenbach J. Melt extrusion: from process to drug deliver technology. Eur. J. Pharm. Biopharm. 54 (2002) 107 (Review article)
3. L. Baert, D. Thone, G. Verreck, Antifungal compositions with improved bioavailability, WO 9,744,014 (1997).
4. Verreck G., Baert L., Peeters J., and Brewster M. Improving aqueous solubility and bioavailability for itraconazole by solid dispersion approach. AAPS PharmSci. 3 3 (2001) M2157
5. Verreck G., Six K., Van den Mooter G., Baert L., Peeters J., and Brewster M.E. Characterization of Solid Dispersions of Itraconazole and Hydroxypropylmethylcellulose prepared by melt extrusion-Part 1. Int. J. Pharm. 251 (2003) 165
6. Six K., Berghmans H., Leuner C., Dressman J., Van Werde K., Mullens J., Benoist L., Thimon M., Meublat L., Verreck G., Peeters J., Brewster M., and Van den Mooter G. Characterization of solid dispersions of itraconazole and hydroxypropylmethylcellulose prepared by melt extrusion-Part II. Pharm. Res. 20 7 (2003) 1047
7. Wu C., and McGinity J.W. Influence of methylparaben as a solid-state plasticizer on the physicochemical properties of Eudragit RS PO hot-melt extrudates. Eur. J. Pharm. and Biopharm. 56 1 (2003) 95
8. Repka M.A., Gerding T.G., Repka S.L., and McGinity J.W. Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion. Drug Dev. Ind. Pharm. 25 5 (1999) 625
9. Mehuys E., Vervaet C., and Remon J.P. Hot-melt extruded ethylcellulose cylinders containing a HPMC-Gelucire core for sustained drug delivery. J. Controlled Release 94 2-3 (2004) 273
10. 2. J. Appl. Polym. Sci. 30 (1985) 2633
11. 2 and subsequent viscosity reduction of an acrylonitrile copolymer. Polymer 45 (2004) 3399
12. Kikic I., Vecchione F., Alessi P., Cortesi A., Eva F., and Elvassore N. Polymer plasticisation using supercritical carbon dioxide: experiment and modelling. Ind. Eng. Chem. Res. 42 13 (2003) 3022
13. Alessi P., Cortesi A., Kikic I., and Vecchione F. Plasticization of polymers with supercritical carbon dioxide: experimental determination of glass-transition temperatures. J. Appl. Pol. Sc. 88 (2003) 2189
14. Handa P.Y., Capowski S., and O'Neill M. Compressed-gas-induced plasticisation of polymers. Thermochim. Acta 226 (1993) 177
15. 2 applications in the processing of polymers. Ind. Eng. Chem. Res. 42 25 (2003) 6431
16. Elkovitch M.D., Lee L.J., and Tomasko D.L. Viscosity reduction of polymers by the addition of supercritical carbon dioxide in polymer processing. ANTEC Tech. Papers (1998) 1407
17. Elkovitch M.D., Tomasko D.L., and Lee L.J. Supercritical carbon dioxide assisted blending of polystyrene and poly(methyl methacrylate). Polym. Eng. Sci. 39 (1999) 2075
18. Lee M., Tzoganakis C., and Park C.B. Extrusion of PE/PS blends with supercritical carbon dioxide. Polym. Eng. Sci. 38 (1998) 1112
19. Park C.B., Baldwin D.F., and Suh N.P. Effect of pressure drop rate on cell nucleation in continuous processing of microcellular polymers. Polym. Eng. Sci. 35 (1995) 432
20. Park C.B., Baldwin D.F., and Suh N.P. Formation and application of polymer/gas mixtures in continuous processing of microcellular polymers. MD 53 (1994) 109
21. Buhler V. Polyvinylpyrrolidone for the Pharmaceutical Industry (1992), BASF Aktiengesellschaft p. 204
22. Mollan M. Historical overview. In: Ghebre-Sellassie I., and Martin C. (Eds). Pharmaceutical Extrusion Technology (2003), Marcel Dekker, NY 1
23. Verreck G., and Brewster M.E. Melt extrusion-based dosage forms: excipients and processing conditions for pharmaceutical formulations. Bull. Tech. Gattefosse 97 (2004) 85
24. Handa P.Y., Kruus P., and O'Neill M. High-pressure calorimetric study of plasticisation of poly(methyl methacrylate) by methane, ethylene, and carbon dioxide. J. Pol. Sci.: Part B: Pol. Phys. 34 (1996) 2635
25. Condo P.D., and Johnston K.P. In situ measurement of the glass transition temperature of polymers with compressed fluid diluents. J. Pol. Sci.: Part B: Pol. Phys. 32× (1994) 523
26. Condo P.D., Paul D.R., and Johnston K.P. Glass transitions of polymers with compressed fluid diluents: types II and III behavior. Macromolecules 27 (1994) 365
27. 2. J. Appl. Pol. Sci. 30 (1985) 2633
28. 2 mixtures at elevated pressures. J. Pol. Sci.: Part B: Pol. Phys. 25 (1987) 2497
29. 2 mixtures at elevated pressures. J. Pol. Sci.: Part B: Pol. Phys. 29 (1991) 631
30. De Brabender C., Van den Mooter G., Vervaet C., and Remon J.P. Characterization of Ibuprofen as a non-traditional plasticizer of ethyl cellulose. J. Pharm. Sci. 91 (2002) 1678
31. Kiran E. Polymer formation, modifications and processing in or with supercritical fluids. In: Kiran E., and Levelt Sengers J.M.H. (Eds). Supercritical Fluids (1994), Kluwer 541
32. L. Baert, D. Thone, G. Verreck, Antifungal compositions with improved bioavailability, PCT Patent Application WO 9,744,014 (1997).
33. Verreck G., Vandecruys R., de Conde V., Baert L., Peeters J., and Brewster M.E. The use of three solid dispersion techniques: melt extrusion, film-coated beads and a glass thermoplastic system to improve the bioavailability of a novel microsomal triglyceride transfer protein (MTP) inhibitor. J. Pharm. Sci. 93 5 (2004) 1217