Antibodies against the Tom40 subunit of the translocase of the outer mitochondrial membrane complex and cognitive impairment in alzheimer's disease

Journal of Alzheimer's Disease

Volumn 29, Issue 2, 2012, Pages 373-377

  Kimura, Akio ^a   Sakurai, Takeo ^a   Yamada, Megumi ^a   Koumura, Akihiro ^a   Hayashi, Yuichi ^a   Tanaka, Yuji ^a   Hozumi, Isao ^a   Ohtaki, Hirofumi ^a   Chousa, Mitsuhiro ^a   Takemura, Masao ^a   Seishima, Mitsuru ^a   Inuzuka, Takashi ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antigen; cognition; dementia; endothelial cell; mitochondrion; pathogenesis

Indexed keywords

ENZYME ANTIBODY; TOM40 ANTIBODY; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME SUBUNIT; FEMALE; HUMAN; HUMAN CELL; MALE; MICROVASCULAR ENDOTHELIAL CELL; MINI MENTAL STATE EXAMINATION; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING;

EID: 84859390959     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-111343     Document Type: Article

References (22)

1. Grammas P, Yamada M, Zlokovic B (2002) The cere-bromicrovasculature: A key player in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 4, 217-223. (Pubitemid 35006053)
2. Zlokovic BV (2002) Vascular disorderinAlzheimer's disease: Role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev 54, 1553-1559. (Pubitemid 35346829)
3. Grammas P, Samany PG, Thirumangalakudi L (2006) Throm-bin and inflammatory proteins are elevated in Alzheimer's disease microvessels: Implications for disease pathogenesis. J Alzheimers Dis 9, 51-58.
4. Christov A, Ottman JT, Grammas P (2004) Vascular inflammatory, oxidative and protease-based processes: Implications for neuronal cell death in Alzheimer's disease. Neurol Res 26, 540-546. (Pubitemid 38879236)
5. Loeffler DA, Juneau PL, Nguyen HU, Najman D, Pomara N, LeWitt PA (1997) Immunocytochemical detection of anti-hippocampal antibodies in Alzheimer's disease and normal cerebrospinal fluid. Neurochem Res 22, 209-214. (Pubitemid 27069098)
6. Bouras C, Riederer BM, Kövari E, Hof PR, Giannakopoulos P (2005) Humoral immunity in brain aging and Alzheimer's disease. Brain Res Brain Res Rev 48, 477-487. (Pubitemid 40731511)
7. Vacirca D, Barbati C, Scazzocchio B, Masella R, Rosano G, Malorni W, Ortona E (2011) Anti-ATP synthase autoan-tibodies from patients with Alzheimer's disease reduce extracellular HDL level. J Alzheimers Dis 25, 1-5.
8. Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, Huentelman MJ, Welsh-Bohmer KA, Reiman EM (2010) A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. Pharmacogenomics J 10, 375-384.
9. Toda T, Kimura N (1997) Standardization of protocol for Immobiline 2-D PAGE and construction of 2-D PAGE protein database on World Wide Web home page. Jpn JElectrophoresis 41, 13-19.
10. Murray IV, Proza JF, Sohrabji F, Lawler JM (2011) Vascular and metabolic dysfunction in Alzheimer's disease: A review. Exp Biol Med 236, 772-782.
11. Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G (2003) Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathologyintransgenic mice.Neurol Res25, 665-674. (Pubitemid 37087612)
12. Gibson GE, Shi Q (2010) A mitocentric view of Alzheimer's disease suggests multi-faceted treatments. J Alzheimers Dis 20 (Suppl 2), S591-S607.
13. Santos RX, Correia SC, Wang X, Perry G, Smith MA, Moreira PI, Zhu X (2010) A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. J Alzheimers Dis 20 (Suppl 2), S401-S412.
14. Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, Ryan MT (2005) Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem 280, 11535-11543. (Pubitemid 40418465)
15. Hong MG, Alexeyenko A, Lambert JC, Amouyel P, Prince JA (2010) Genome-wide pathway analysis implicates intracellu-lar transmembrane protein transport in Alzheimer disease. J Hum Genet 55, 707-709.
16. Roses AD (2010) An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Arch Neurol 67, 536-541.
17. Devi L, Prabhu BM, Galati DF, Avadhani NG, Anan-datheerthavarada HK (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brainisassociated withmitochon-drial dysfunction. J Neurosci 26, 9057-9068. (Pubitemid 44319397)
18. Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG (2003) Mitochondrial targeting and a novel transmem-brane arrestof Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161, 41-54. (Pubitemid 36459078)
19. Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, Leinonen V, Ito A, Winblad B, Glaser E, Ankarcrona M (2008) The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci USA 105, 13145-13150.
20. Grossman I, Lutz MW, Crenshaw DG, Saunders AM, Burns DK, Roses AD (2010) Alzheimer's disease: Diagnostics, prognostics and the road to prevention. EPMA J 1, 293-303.
21. Deng SX, Hanson E, Sanz I (2000) In vivocell penetration and intracellular transport of anti-Sm and anti-La autoantibodies. Int Immunol 12, 415-123.
22. Seddiki N, Nato F, Lafaye P, Amoura Z, Piette JC, Mazié JC (2001) Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies. J Immunol 166, 6423-6429. (Pubitemid 32440777)