Inhibition of the p38 MAPK pathway ameliorates renal fibrosis in an NPHP2 mouse model

Nephrology Dialysis Transplantation

Volumn 27, Issue 4, 2012, Pages 1351-1358

  Sugiyama, Noriyuki ^a   Kohno, Michiaki ^b   Yokoyama, Takahiko ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

cyst; fibrosis; inv; NPHP2; p38 MAPK

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLLAGEN 1 ALPHA 1 GENE; COLLAGEN 3 ALPHA 1 GENE; COLLAGEN 4 ALPHA 1 GENE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION REGULATION; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; MOUSE; NEPHRONOPHTHISIS; NONHUMAN; PRIORITY JOURNAL; TRANSFORMING GROWTH FACTOR BETA1 GENE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CYSTS; DISEASE MODELS, ANIMAL; FIBROSIS; GROWTH INHIBITORS; HUMANS; KIDNEY DISEASES; MICE; MICE, TRANSGENIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRAZOLES; PYRIDINES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84859340721     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr550     Document Type: Article

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