Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation

Internal Medicine

Volumn 51, Issue 7, 2012, Pages 777-782

  Arai, Ayako ^a   Imadome, Ken Ichi ^b   Wang, Ludan ^a   Wu, Nan ^a   Kurosu, Tetsuya ^a   Wake, Atsushi ^c   Yamamoto, Hisashi ^c   Ota, Yasunori ^c   Harigai, Masayoshi ^a   Fujiwara, Shigeyoshi ^b   Miura, Osamu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c TORANOMON HOSPITAL   (Japan)

Author keywords

Bone marrow transplantation; Chronic active Epstein Barr virus infection; Systemic lupus erythematosus

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN; FLUDARABINE; HYDROCORTISONE; MELPHALAN; METHOTREXATE;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CASE REPORT; CELL INFILTRATION; CHRONIC ACTIVE EPSTEIN BARR VIRUS INFECTION; CONTROLLED STUDY; EPSTEIN BARR VIRUS INFECTION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; KARYOTYPE 46, XY; LIVER BIOPSY; LIVER DYSFUNCTION; LOW DRUG DOSE; LYMPHOBLASTOID CELL LINE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RECURRENT DISEASE; RELAPSE; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; T CELL LYMPHOPROLIFERATIVE DISEASE; VIRUS STRAIN; WHOLE BODY RADIATION;

ADULT; BASE SEQUENCE; BONE MARROW TRANSPLANTATION; CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; CHRONIC DISEASE; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOPROLIFERATIVE DISORDERS; MALE; RECURRENCE; T-LYMPHOCYTES; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84859321054     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.51.6769     Document Type: Article

References (18)

1. Kawa K. Epstein-Barr virus-associated diseases in humans. Int J Hematol 71: 108-117, 2000.
2. Quintanilla-Martinez L, Kimura H, Jaffe ES. EBV-positive T-cell lymphoproliferative disorders of childhood. In: World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Jaffe ES, Harris NL, Stein H, et al, Eds. IARC Press, Lyon, 2008: 527-533.
3. Kimura H, Morishima T, Kanegane H, et al. Prognostic factors for chronic active Epstein-Barr virus infection. J Infect Dis 187: 527-533, 2003.
4. Arai A, Imadome K, Watanabe Y, et al. Clinical features of adultonset chronic active Epstein-Barr virus infection: a retrospective analysis. Int J Hematol 93: 602-609, 2011.
5. Imadome K, Shimizu N, Arai A, et al. Coexpression of CD40 and CD40 ligand in Epstein-Barr virus-infected T and NK cells and their role in cell survival. J Infect Dis 192: 1340-1348, 2005.
6. Stepp SE, Dufourcq-Lagelouse R, Le Deist F, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286: 1957-1959, 1999.
7. Koyama M, Takeshita Y, Sakata A, et al. Cytotoxic chemotherapy successfully induces durable complete remission in 2 patients with mosquito allergy resulting from Epstein-Barr virus-associated T-/ natural killer cell lymphoproliferative disease. Int J Hematol 82: 437-440, 2005.
8. Anagnostopoulos I, Hummel M, Kreschel C, Stein H. Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus. Blood 85: 744-750, 1995.
9. Kasahara Y, Yachie A, Takei K, et al. Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBVassociated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood 98: 1882-1888, 2001.
10. Ohshima K, Kimura H, Yoshino T, et al. Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults: overlap with chronic active EBV infection and infantile fulminant EBV T-LPD. Pathol Int 58: 209-217, 2008.
11. Sugaya N, Kimura H, Hara S, et al. Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in patients with chronic active EBV infection. J Infect Dis 190: 985-988, 2004.
12. Katano H, Ali MA, Patera AC, et al. Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation. Blood 103: 1244-1252, 2004.
13. Arai A, Imadome K, Fujiwara S, Miura O. Autoimmune hemolytic anemia accompanied by reactivation of an Epstein-Barr virus infection with suppressed CTL response to EBV-infected cells in an elderly man. Intern Med 49: 325-329, 2010.
14. Ogawa J, Koike R, Sugihara T, et al. An autopsied case of chronic active Epstein-Barr virus infection complicated in systemic lupus erythematosus and antiphospholipid antibody syndrome. Nihon Rinsho Meneki Gakkai Kaishi 25: 458-465, 2002 (in Japanese, Abstract in English).
15. Arai A, Takahashi M, Imadome K, et al. NF-kB is constitutively activated in EBV-infected T or NK cells and can be a molecular target for EBV-positive T/NK-cell lymphoproliferative disease treatment. Blood 116: 1998, 2010 (Abstract).
16. Imadome K, Yajima M, Arai A, et al. Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-Infected T and NK cells. PLoS Pathog 7: e1002326, 2011.
17. Young KH, Zhang D, Malik JT, Williams E. Fulminant EBVdriven CD8 T-cell lymphoproliferative disorder following primary acute EBV infection: a unique spectrum of T-cell malignancy. Int J Clin Exp Pathol 1: 185-197, 2008.
18. Tokuhira M, Hanzawa K, Watanabe R, et al. Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report. J Hematol Oncol 2: 27, 2009.