Integration of an abdominal Hox complex with PAX2 yields cell-specific EGF secretion from Drosophila sensory precursor cells

Development

Volumn 139, Issue 9, 2012, Pages 1611-1619

  Li Kroeger, David ^a   Cook, Tiffany A ^a   Gebelein, Brian ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cis regulatory modules; Drosophila; EGF; Hox factors

Indexed keywords

EPIDERMAL GROWTH FACTOR; HOX PROTEIN; SERINE PROTEINASE; TRANSCRIPTION FACTOR PAX2;

ABDOMEN; ARTICLE; CELL FATE; CELL SPECIFICITY; CELL TYPE; DROSOPHILA; GENE EXPRESSION; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION REGULATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DROSOPHILA; DROSOPHILA PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IMMUNOPRECIPITATION; LUCIFERASES; MEMBRANE PROTEINS; MULTIPROTEIN COMPLEXES; MUTAGENESIS; NEURAL STEM CELLS; PAX2 TRANSCRIPTION FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84859320387     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.077842     Document Type: Article

References (36)

1. Aspland, S. E. and White, R. A. (1997). Nucleocytoplasmic localisation of extradenticle protein is spatially regulated throughout development in Drosophila. Development 124, 741-747.
2. Berger, M. F., Badis, G., Gehrke, A. R., Talukder, S., Philippakis, A. A., Pena-Castillo, L., Alleyne, T. M., Mnaimneh, S., Botvinnik, O. B., Chan, E. T. et al. (2008). Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133, 1266-1276.
3. Brodu, V., Elstob, P. R. and Gould, A. P. (2002). abdominal A specifies one cell type in Drosophila by regulating one principal target gene. Development 129, 2957-2963.
4. Brodu, V., Elstob, P. R. and Gould, A. P. (2004). EGF receptor signaling regulates pulses of cell delamination from the Drosophila ectoderm. Dev. Cell 7, 885-895.
5. Carroll, S. B., Grenier, J. K. and Weatherbee, S. D. (2001). From DNA to Diversity. Malden, MA: Blackwell Science.
6. Charlton-Perkins, M., Whitaker, S. L., Fei, Y., Xie, B., Li-Kroeger, D., Gebelein, B. and Cook, T. (2011). Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras-and Notch-dependent signaling. Neural Dev. 6, 20.
7. Davidson, E. H. and Levine, M. S. (2008). Properties of developmental gene regulatory networks. Proc. Natl. Acad. Sci. USA 105, 20063-20066.
8. Ekker, S. C., Jackson, D. G., von Kessler, D. P., Sun, B. I., Young, K. E. and Beachy, P. A. (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13, 3551-3560.
9. Elstob, P. R., Brodu, V. and Gould, A. P. (2001). spalt-dependent switching between two cell fates that are induced by the Drosophila EGF receptor. Development 128, 723-732.
10. Fu, W., Duan, H., Frei, E. and Noll, M. (1998). shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog. Development 125, 2943-2950.
11. Gebelein, B. and Urrutia, R. (2001). Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppel-associated box protein. Mol. Cell. Biol. 21, 928-939.
12. Gebelein, B., Culi, J., Ryoo, H. D., Zhang, W. and Mann, R. S. (2002). Specificity of Distalless repression and limb primordia development by abdominal Hox proteins. Dev. Cell 3, 487-498.
13. Gebelein, B., McKay, D. J. and Mann, R. S. (2004). Direct integration of Hox and segmentation gene inputs during Drosophila development. Nature 431, 653-659.
14. Gong, K. Q., Yallowitz, A. R., Sun, H., Dressler, G. R. and Wellik, D. M. (2007). A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol. Cell. Biol. 27, 7661-7668.
15. Grienenberger, A., Merabet, S., Manak, J., Iltis, I., Fabre, A., Berenger, H., Scott, M. P., Pradel, J. and Graba, Y. (2003). Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development 130, 5445-5455.
16. Gutzwiller, L. M., Witt, L. M., Gresser, A. L., Burns, K. A., Cook, T. A. and Gebelein, B. (2010). Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen. Dev. Biol. 348, 231-243.
17. Jun, S. and Desplan, C. (1996). Cooperative interactions between paired domain and homeodomain. Development 122, 2639-2650.
18. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
19. Kurant, E., Eytan, D. and Salzberg, A. (2001). Mutational analysis of the Drosophila homothorax gene. Genetics 157, 689-698.
20. Levine, M. (2010). Transcriptional enhancers in animal development and evolution. Curr. Biol. 20, R754-R763.
21. Levine, M. and Davidson, E. H. (2005). Gene regulatory networks for development. Proc. Natl. Acad. Sci. USA 102, 4936-4942.
22. Lewis, E. B. (1978). Gene complex controlling segmentation in Drosophila. Nature 276, 565-570.
23. Li-Kroeger, D., Witt, L. M., Grimes, H. L., Cook, T. A. and Gebelein, B. (2008). Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev. Cell 15, 298-308.
24. Manak, J. R., Mathies, L. D. and Scott, M. P. (1994). Regulation of a decapentaplegic midgut enhancer by homeotic proteins. Development 120, 3605-3619.
25. Mann, R. S., Lelli, K. M. and Joshi, R. (2009). Hox specificity unique roles for cofactors and collaborators. Curr. Top. Dev. Biol. 88, 63-101.
26. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
27. Noro, B., Culi, J., McKay, D. J., Zhang, W. and Mann, R. S. (2006). Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes Dev. 20, 1636-1650.
28. Noyes, M. B., Christensen, R. G., Wakabayashi, A., Stormo, G. D., Brodsky, M. H. and Wolfe, S. A. (2008). Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133, 1277-1289.
29. Pearson, J. C., Lemons, D. and McGinnis, W. (2005). Modulating Hox gene functions during animal body patterning. Nat. Rev. Genet. 6, 893-904.
30. Rauskolb, C., Peifer, M. and Wieschaus, E. (1993). extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74, 1101-1112.
31. Rusten, T. E., Cantera, R., Urban, J., Technau, G., Kafatos, F. C. and Barrio, R. (2001). Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes. Development 128, 711-722.
32. Shilo, B. Z. (2005). Regulating the dynamics of EGF receptor signaling in space and time. Development 132, 4017-4027.
33. Uhl, J. D., Cook, T. A. and Gebelein, B. (2010). Comparing anterior and posterior Hox complex formation reveals guidelines for predicting cis-regulatory elements. Dev. Biol. 343, 154-166.
34. Vachon, G., Cohen, B., Pfeifle, C., McGuffin, M. E., Botas, J. and Cohen, S. M. (1992). Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71, 437-450.
35. Witt, L. M., Gutzwiller, L. M., Gresser, A. L., Li-Kroeger, D., Cook, T. A. and Gebelein, B. (2010). Atonal, Senseless, and Abdominal-A regulate rhomboid enhancer activity in abdominal sensory organ precursors. Dev. Biol. 344, 1060-1070.
36. Xie, B., Charlton-Perkins, M., McDonald, E., Gebelein, B. and Cook, T. (2007). Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development 134, 4243-4253.