Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model

Thrombosis and Haemostasis

Volumn 107, Issue 4, 2012, Pages 690-698

  Heeb, Mary J ^a   Marzec, Ulla ^b   Gruber, Andras ^b   Hanson, Stephen R ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Oregon Health and Science University Department of Biomedical Engineering   (United States)

Author keywords

Anticoagulants; Platelets; Protein S; Thrombosis model

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; PLASMA PROTEIN; PROTEIN S; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTERIOVENOUS SHUNT; ARTICLE; BABOON; BLOOD FLOW VELOCITY; CONTROLLED STUDY; FIBRIN DEPOSITION; INFUSION PUMP; MALE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOGENESIS; THROMBOSIS;

ANIMALS; ANTICOAGULANTS; BLOOD PLATELETS; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; FIBRIN; FIBRINOLYTIC AGENTS; HEMOSTASIS; HUMANS; MALE; NEOPLASM PROTEINS; PAPIO; PROTEIN C; PROTEIN C DEFICIENCY; PROTEIN S; THROMBOSIS; TIME FACTORS; ZINC;

EID: 84859316481     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th11-10-0699     Document Type: Article

References (28)

1. Mahasandana C, Suvatte V, Marlar RA, et al. Neonatal purpura fulminans associated with homozygous protein S deficiency (Letter). Lancet 1990; 335: 61-62.
2. Schwarz HP, Fischer M, Hopmeier P, et al. Plasma protein S deficiency in familial thrombotic disease. Blood 1984; 64: 1297-1300.
3. Mahmoodi BK, Brouwer JL, Veeger NJ, et al. Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age: results from a large family cohort study. Circulation 2008; 118: 1659-1667.
4. Burstyn-Cohen T, Heeb MJ, Lemke G. Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest 2009; 119: 2942-2953.
5. Walker FJ. Regulation of activated protein C by a new protein. A possible function for bovine protein S. J Biol Chem 1980; 255: 5521-5524.
6. Heeb MJ, Mesters RM, Tans G, et al. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem 1993; 268: 2872-2877.
7. Heeb MJ, Rosing J, Bakker HM, et al. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci USA 1994; 91: 2728-2732.
8. Hackeng TM, van't Veer C, Meijers JCM, et al. Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa. J Biol Chem 1994; 269: 21051-21058.
9. Koppelman SJ, Hackeng TM, Sixma JJ, et al. Inhibition of the intrinsic factor X activating complex by protein S: evidence for a specific binding of protein S to factor VIII. Blood 1995; 86: 1062-1071.
10. Fernandes NL, Mosnier LO, Tonnu L, et al. Zinc-containing protein S inhibits extrinsic factor X activating complex independently of tissue factor pathway inhibitor. Journal of Thrombosis and Haemostasis 2010; 8: 1976-1985.
11. Takeyama M, Nogami K, Saenko EL, et al. Identification of a protein S-interactive site within the A2 domain of the factor VIII heavy chain. Thromb Haemost 2009; 102: 645-655.
12. Heeb MJ, Prashun D, Griffin JH, et al. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J 2009; 23: 2244-2253.
13. Heeb MJ, Radtke K-P, Fernandez JA, et al. Plasma contains protein S monomers and multimers with similar direct anticoagulant activity. J Thromb Haemost 2006; 4: 2215-2222.
14. Hackeng T, Sere KM, Tans G, et al. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proc Natl Acad Sci USA 2006; 103: 3106-3111.
15. Gruber A, Griffin JH, Harker L, et al. Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model. Blood 1989; 73: 639-642.
16. Hanson SR, Griffin JH, Harker LA, et al. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest 1993; 92: 2003-2012.
17. Scott NA, Nunes GL, King SB, et al. Local delivery of an antithrombin inhibits platelet- dependent thrombosis. Circulation 1994; 90: 1951-1955.
18. Matthay MA. Severe sepsis--a new treatment with both anticoagulant and antiinflammatory properties. N Engl J Med 2001; 344: 759-762.
19. Grinnell BW, Walls JD, Marks C, et al. Gamma-Carboxylated isoforms of recombinant human protein S with different biologic properties. Blood 1990; 76: 2546-2554.
20. Markou CP, Lutostansky EM, Ku DN, et al. A novel method for efficient drug delivery. Ann Biomed Eng 1998; 26: 502-511.
21. Heeb MJ, Schuck P, Xu X. Protein S multimers and monomers each have direct anticoagulant activity. J Thromb Haemost 2006; 4: 385-391.
22. Fernandez JA, Heeb MJ, Xu X, et al. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica 2009; 94: 1721-1731.
23. Sen P, Sahoo S, Pendurthi UR, et al. Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor. J Biol Chem 2010; 285: 20410-20420.
24. Zhu T, Ubhayasekera W, Nickolaus N, et al. Zinc ions bind to and inhibit activated protein C. Thromb Haemost 2010; 104: 544-553.
25. Tanaka KA, Fernandez JA, Marzec UM, et al. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates. Br J Haematol 2006; 132: 197-203.
26. Ndonwi M, Broze G, Jr. Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor. J Thromb Haemost 2008; 6: 1044-1046.
27. Kask L, Trouw LA, Dahlback B, et al. The C4b-binding protein-protein S complex inhibits the phagocytosis of apoptotic cells. J Biol Chem 2004; 279: 23869-23873.
28. Hurtado B, Munoz X, Recarte-Pelz P, et al. Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques. Thromb Haemost 2011; 105: 873-882.