Protein S multimers and monomers each have direct anticoagulant activity

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 2, 2006, Pages 385-391

  Heeb, M J ^a   Schuck, P ^b   Xu, X ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Analytical ultracentrifugation; Anticoagulant activity; Multimeric protein; Protein S; Prothrombinase

Indexed keywords

BARIUM; BLOOD CLOTTING FACTOR 10A; CALCIUM ION; EDETIC ACID; MONOMER; PHOSPHOLIPID; POLYMER; PROTEIN S; RECOMBINANT PROTEIN; ANTICOAGULANT AGENT; C4BPA PROTEIN, HUMAN; HISTOCOMPATIBILITY ANTIGEN; LIGAND;

ANTICOAGULATION; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; SEPARATION TECHNIQUE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THROMBIN TIME; BINDING COMPETITION; CHEMISTRY; COMPARATIVE STUDY; DIMERIZATION; HUMAN; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN QUATERNARY STRUCTURE; ULTRACENTRIFUGATION;

ANTICOAGULANTS; BINDING, COMPETITIVE; DIMERIZATION; FACTOR XA; HISTOCOMPATIBILITY ANTIGENS; HUMANS; LIGANDS; PHOSPHOLIPIDS; PROTEIN S; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; ULTRACENTRIFUGATION;

EID: 33645571094     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.01743.x     Document Type: Article

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