Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates

British Journal of Haematology

Volumn 132, Issue 2, 2006, Pages 197-203

  Tanaka, Kenichi A ^a   Fernández, José A ^b   Marzec, Ulla M ^c   Kelly, Andrew B ^a   Mohri, Mitsunobu ^d   Griffin, John H ^b   Hanson, Stephen R ^c   Gruber, Andras ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Oregon Health and Science University Department of Biomedical Engineering   (United States)

^d ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Activated protein C; Anticoagulants; Thrombin; Thrombomodulin

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; BETA THROMBOGLOBULIN; FIBRINOPEPTIDE A; NEUTRALIZING ANTIBODY; POLYESTER; PROTEIN C; RECOMBINANT THROMBOMODULIN; THROMBIN ANTITHROMBIN COMPLEX; ANTITHROMBIN III; ANTITHROMBIN III PROTEASE COMPLEX; ANTITHROMBIN III-PROTEASE COMPLEX; FIBRIN; MONOCLONAL ANTIBODY; PEPTIDE HYDROLASE; RECOMBINANT PROTEIN; THROMBOMODULIN;

ACUTE VASCULAR GRAFT THROMBOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS SHUNT; ARTICLE; BABOON; BLEEDING TIME; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; DOSE RESPONSE; GRAFT DYSFUNCTION; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; THROMBOSIS; ANIMAL; BLOOD; DRUG EFFECT; GRAFT OCCLUSION; IMMUNOLOGY; METABOLISM; PAPIO; PARTIAL THROMBOPLASTIN TIME; PHYSIOLOGY; SOLUBILITY; THROMBOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTICOAGULANTS; ANTITHROMBIN III; BLOOD COAGULATION; BLOOD PLATELETS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRIN; GRAFT OCCLUSION, VASCULAR; MALE; PAPIO; PARTIAL THROMBOPLASTIN TIME; PEPTIDE HYDROLASES; PROTEIN C; RECOMBINANT PROTEINS; SOLUBILITY; THROMBOMODULIN; THROMBOSIS;

EID: 33644828014     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05855.x     Document Type: Article

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