Panton-Valentine leukocidin gene sequence variation and phage in methicillin-resistant and methicillin-susceptible Staphylococcus aureus from children in mainland China

Microbiology and Immunology

Volumn 56, Issue 3, 2012, Pages 155-162

  Li, Xiangmei ^a   Sun, Jing ^a   Wu, Dejing ^a   Wang, Lijuan ^a   Yang, Yonghong ^a   Wang, Chuanqing ^b   Liu, Lan ^c   Zhao, Changan ^d   Du, Pengcheng ^e   Yu, Sangjie ^a   Shen, Xuzhuang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

^c Chongqing Children's Hospital   (China)

^d Guangzhou Maternal and Child Health Hospital   (China)

^e Institute for Communicable Disease Control and Prevention China CDC   (China)

Author keywords

Panton Valentine leukocidin; Phage; Sequence variation; Staphylococcus aureus

Indexed keywords

CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; LINEZOLID; OXACILLIN; PENICILLIN G; PSEUDOMONIC ACID; RIFAMPICIN; TETRACYCLINE; TIGECYCLINE; VANCOMYCIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIOPHAGE TYPING; BACTERIUM ISOLATION; CHILD; CHINA; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE LOCATION; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; INFANT; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MOLECULAR TYPING; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PANTON VALENTINE LEUKOCIDIN GENE; POLYMERASE CHAIN REACTION; SCHOOL CHILD; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE;

BACTERIAL TOXINS; CHILD; CHILD, PRESCHOOL; CHINA; DNA PRIMERS; DNA, BACTERIAL; EXOTOXINS; FEMALE; HUMANS; INFANT; LEUKOCIDINS; MALE; METHICILLIN RESISTANCE; MOLECULAR SEQUENCE DATA; MOLECULAR TYPING; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROPHAGES; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS PHAGES;

STAPHYLOCOCCUS AUREUS;

EID: 84859300086     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2011.00422.x     Document Type: Article

References (30)

1. Lowy, F.D. (1998) Staphylococcus aureus infections. N Engl J Med 339: 520-32.
2. Lina, G., Piemont, Y., Godail-Gamot, F., Bes, M., Peter, M.O., Gauduchon, V., Vandenesch, F., Etienne, J. (1999) Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 29: 1128-32.
3. Tristan, A., Bes, M., Meugnier, H., Lina, G., Bozdogan, B., Courvalin, P., Reverdy, M.E., Enright, M.C., Vandenesch, F., Etienne, J. (2007) Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006. Emerg Infect Dis 13: 594-600.
4. Diep, B.A., Gill, S.R., Chang, R.F., Phan, T.H., Chen, J.H., Davidson, M.G., Lin, F., Lin, J., Carleton, H.A., Mongodin, E.F., Sensabaugh, G.F., Perdreau-Remington, F. (2006) Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 367: 731-9.
5. Ma, X.X., Ito, T., Kondo, Y., Cho, M., Yoshizawa, Y., Kaneko, J., Katai, A., Higashiide, M., Li, S., Hiramatsu, K. (2008) Two different Panton-Valentine leukocidin phage lineages predominate in Japan. J Clin Microbiol 46: 3246-58.
6. Takano, T., Higuchi, W., Otsuka, T., Baranovich, T., Enany, S., Saito, K., Isobe, H., Dohmae, S., Ozaki, K., Takano, M., Iwao, Y., Shibuya, M., Okubo, T., Yabe, S., Shi, D., Reva, I., Teng, L.J., Yamamoto, T. (2008) Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan. Antimicrob Agents Chemother 52: 837-45.
7. O'hara, F.P., Guex, N., Word, J.M., Miller, L.A., Becker, J.A., Walsh, S.L., Scangarella, N.E., West, J.M., Shawar, R.M., Amrine-Madsen, H. (2008) A geographic variant of the Staphylococcus aureus Panton-Valentine leukocidin toxin and the origin of community-associated methicillin-resistant S. aureus USA300. J Infect Dis 197: 187-94.
8. Berglund, C., Prevost, G., Laventie, B.J., Keller, D., Soderquist, B. (2008) The genes for Panton Valentine leukocidin (PVL) are conserved in diverse lines of methicillin-resistant and methicillin-susceptible Staphylococcus aureus. Microbes Infect 10: 878-84.
9. Wolter, D.J., Tenover, F.C., Goering, R.V. (2007) Allelic variation in genes encoding Panton-Valentine leukocidin from community-associated Staphylococcus aureus. Clin Microbiol Infect 13: 827-30.
10. John, J.F., Jr., Lindsay, J.A. (2008) Clones and drones: do variants of Panton-Valentine leukocidin extend the reach of community-associated methicillin-resistant Staphylococcus aureus? J Infect Dis 197: 175-8.
11. Boakes, E., Kearns, A.M., Ganner, M., Perry, C., Hill, R.L., Ellington, M.J. Distinct bacteriophages encoding Panton-Valentine leukocidin (PVL) among international methicillin-resistant Staphylococcus aureus clones harboring PVL. J Clin Microbiol 49: 684-92.
12. Zhang, M., Ito, T., Li, S., Jin, J., Takeuchi, F., Lauderdale, T.L., Higashide, M., Hiramatsu, K. (2011) Identification of the third type of PVL phage in ST59 methicillin-resistant Staphylococcus aureus (MRSA) strains. FEMS Microbiol Lett 323: 20-8.
13. Geng, W., Yang, Y., Wu, D., Huang, G., Wang, C., Deng, L., Zheng, Y., Fu, Z., Li, C., Shang, Y., Zhao, C., Yu, S., Shen, X. Molecular characteristics of community-acquired, methicillin-resistant Staphylococcus aureus isolated from Chinese children. FEMS Immunol Med Microbiol 58: 356-62.
14. Shen, X.Z., Wu, D.J., Wang, Q., Yang, Y.H., Geng, W.J., Wang, Q., Yu, S.J.E., Yao, K.H., Yuan, L. (2010) Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in a children's hospital in Beijing, China. Diagn Microbiol Infect Dis 67: 1-8.
15. Bignardi, G.E., Woodford, N., Chapman, A., Johnson, A.P., Speller, D.C. (1996) Detection of the mec-A gene and phenotypic detection of resistance in Staphylococcus aureus isolates with borderline or low-level methicillin resistance. J Antimicrob Chemother 37: 53-63.
16. Brakstad, O.G., Aasbakk, K., Maeland, J.A. (1992) Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol 30: 1654-60.
17. Klevens, R.M., Morrison, M.A., Nadle, J., Petit, S., Gershman, K., Ray, S., Harrison, L.H., Lynfield, R., Dumyati, G., Townes, J.M., Craig, A.S., Zell, E.R., Fosheim, G.E., Mcdougal, L.K., Carey, R.B., Fridkin, S.K. (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298: 1763-71.
18. Enright, M.C., Day, N.P., Davies, C.E., Peacock, S.J., Spratt, B.G. (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38: 1008-15.
19. Milheirico, C., Oliveira, D.C., De Lencastre, H. (2007) Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 51: 3374-77.
20. Kreiswirth, B.N., Koreen, L., Ramaswamy, S.V., Graviss, E.A., Naidich, S., Musser, J.A. (2004) spa Typing method for discriminating among Staphylococcus aureus isolates: Implications for use of a single marker to detect genetic micro- and macrovariation. J Clin Microbiol 42: 792-99.
21. Holtfreter, S., Grumann, D., Schmudde, M., Nguyen, H.T.T., Eichler, P., Strommenger, B., Kopron, K., Kolata, J., Giedrys-Kalemba, S., Steinmetz, I., Witte, W., Broker, B.M. (2007) Clonal distribution of superantigen genes in clinical Staphylococcus aureus isolates. J Clin Microbiol 45: 2669-80.
22. Otter, J.A., Kearns, A.M., French, G.L., Ellington, M.J. Panton-Valentine leukocidin-encoding bacteriophage and gene sequence variation in community-associated methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 16: 68-73.
23. Narita, S., Kaneko, J., Chiba, J., Piemont, Y., Jarraud, S., Etienne, J., Kamio, Y. (2001) Phage conversion of Panton-Valentine leukocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, phiSLT. Gene 268: 195-206.
24. Dumitrescu, O., Tristan, A., Meugnier, H., Bes, M., Gouy, M., Etienne, J., Lina, G., Vandenesch, F. (2008) Polymorphism of the Staphylococcus aureus Panton-Valentine leukocidin genes and its possible link with the fitness of community-associated methicillin-resistant S. aureus. J Infect Dis 198: 792-4.
25. Besseyre Des Horts, T., Dumitrescu, O., Badiou, C., Thomas, D., Benito, Y., Etienne, J., Vandenesch, F., Lina, G. A histidine-to-arginine substitution in Panton-Valentine leukocidin from USA300 community-acquired methicillin-resistant Staphylococcus aureus does not impair its leukotoxicity. Infect Immun 78: 260-4.
26. Tong, S.Y., Lilliebridge, R.A., Bishop, E.J., Cheng, A.C., Holt, D.C., Mcdonald, M.I., Giffard, P.M., Currie, B.J., Boutlis, C.S. Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. J Infect Dis 202: 760-9.
27. Tong, S.Y., Lilliebridge, R.A., Holt, D.C., Coombs, G.W., Currie, B.J., Giffard, P.M. Rapid detection of H and R Panton-Valentine leukocidin isoforms in Staphylococcus aureus by high-resolution melting analysis. Diagn Microbiol Infect Dis 67: 399-401.
28. Rasigade, J.P., Laurent, F., Lina, G., Meugnier, H., Bes, M., Vandenesch, F., Etienne, J., Tristan, A. Global distribution and evolution of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus, 1981-2007. J Infect Dis 201: 1589-97.
29. Boakes, E., Kearns, A.M., Ganner, M., Perry, C., Warner, M., Hill, R.L., Ellington, M.J. (2011) Molecular diversity within clonal complex 22 methicillin-resistant Staphylococcus aureus encoding Panton-Valentine leukocidin in England and Wales. Clinical Microbiology and Infection 17: 140-45.
30. Goerke, C., Wirtz, C., Witte, W., Wolz, C. (2010) Insertion of host DNA into PVL-encoding phages of the Staphylococcus aureus lineage ST80 by intra-chromosomal recombination. Virology 406: 322-27.