메뉴 건너뛰기




Volumn 7, Issue 4, 2012, Pages

Gender dimorphism in aspartame-induced impairment of spatial cognition and insulin sensitivity

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTAME; GLUCOSE;

EID: 84859256911     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031570     Document Type: Article
Times cited : (53)

References (81)
  • 1
    • 2442656247 scopus 로고    scopus 로고
    • Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats
    • Christian B, McConnaughey K, Bethea E, Brantley S, Coffey A, et al. (2004) Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats. Pharmacol Biochem Behav 78 (1): 121-127.
    • (2004) Pharmacol Biochem Behav , vol.78 , Issue.1 , pp. 121-127
    • Christian, B.1    McConnaughey, K.2    Bethea, E.3    Brantley, S.4    Coffey, A.5
  • 2
    • 47949129036 scopus 로고    scopus 로고
    • Direct and indirect cellular effects of aspartame on the brain
    • Humphries P, Pretorius E, Naude H, (2008) Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutrition 62: 451-462.
    • (2008) Eur J Clin Nutrition , vol.62 , pp. 451-462
    • Humphries, P.1    Pretorius, E.2    Naude, H.3
  • 4
    • 0015764485 scopus 로고
    • Brain lesions in mouse infants and fetuses induced by monosodium L. aspartate
    • Inouye M, Murakami U, (1973) Brain lesions in mouse infants and fetuses induced by monosodium L. aspartate. Congen Anomal 13: 235-244.
    • (1973) Congen Anomal , vol.13 , pp. 235-244
    • Inouye, M.1    Murakami, U.2
  • 5
    • 0026793010 scopus 로고
    • Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate
    • Arai T, Hasegawa Y, Oki Y, (1992) Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate. Res Vet Sci 53 (2): 247-249.
    • (1992) Res Vet Sci , vol.53 , Issue.2 , pp. 247-249
    • Arai, T.1    Hasegawa, Y.2    Oki, Y.3
  • 6
    • 0342313567 scopus 로고    scopus 로고
    • Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice
    • Park CH, Choi SH, Piao Y, Kim S, Lee YJ, et al. (2000) Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice. Toxicol Lett 115 (2): 117-125.
    • (2000) Toxicol Lett , vol.115 , Issue.2 , pp. 117-125
    • Park, C.H.1    Choi, S.H.2    Piao, Y.3    Kim, S.4    Lee, Y.J.5
  • 7
    • 78049297042 scopus 로고    scopus 로고
    • Phenylketonuria
    • Lancet 76
    • Blau N, van Spronsen FJ, Levy HL, (2010) Phenylketonuria. 9750 Lancet 76 pp. 1417-1427.
    • (2010) , Issue.9750 , pp. 1417-1427
    • Blau, N.1    van Spronsen, F.J.2    Levy, H.L.3
  • 8
    • 0029680347 scopus 로고    scopus 로고
    • The phenylalanine hydroxylase locus: a marker for the history of phenylketonuria and human genetic diversity
    • Scriver CR, Byck S, Prevost L, Hoang L, (1996) The phenylalanine hydroxylase locus: a marker for the history of phenylketonuria and human genetic diversity. PAH Mutation Analysis Consortium, Ciba Found Symp 197: 73-90.
    • (1996) PAH Mutation Analysis Consortium, Ciba Found Symp , vol.197 , pp. 73-90
    • Scriver, C.R.1    Byck, S.2    Prevost, L.3    Hoang, L.4
  • 9
    • 0015716735 scopus 로고
    • Classic phenylketonuria: heterozygote detection during pregnancy
    • Griffin RF, Humienny ME, Hall EC, Elsas LJ, (1973) Classic phenylketonuria: heterozygote detection during pregnancy. Am J Hum Genet 25 (6): 646-654.
    • (1973) Am J Hum Genet , vol.25 , Issue.6 , pp. 646-654
    • Griffin, R.F.1    Humienny, M.E.2    Hall, E.C.3    Elsas, L.J.4
  • 10
    • 0017663644 scopus 로고
    • Detection of heterozygotes for phenylketonuria. Total body phenylalanine clearance and concentrations of phenylalanine and tyrosine in the plasms of fasting subjects compared
    • Jagenburg R, Regårdh CG, Rödjer S, (1977) Detection of heterozygotes for phenylketonuria. Total body phenylalanine clearance and concentrations of phenylalanine and tyrosine in the plasms of fasting subjects compared. Clin Chem 23 (9): 1654-1660.
    • (1977) Clin Chem , vol.23 , Issue.9 , pp. 1654-1660
    • Jagenburg, R.1    Regårdh, C.G.2    Rödjer, S.3
  • 11
    • 0025133228 scopus 로고
    • Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria
    • Stegink LD, Filer LJ Jr, Bell EF, Ziegler EE, Tephly TR, et al. (1990) Repeated ingestion of aspartame-sweetened beverages: further observations in individuals heterozygous for phenylketonuria. Metabolism 39 (10): 1076-1081.
    • (1990) Metabolism , vol.39 , Issue.10 , pp. 1076-1081
    • Stegink, L.D.1    Filer Jr., L.J.2    Bell, E.F.3    Ziegler, E.E.4    Tephly, T.R.5
  • 13
    • 80051546044 scopus 로고    scopus 로고
    • Phenylketonuria-related synaptic changes in a BTBR-Pah(enu2) mouse model
    • Liang L, Gu X, Lu L, Li D, Zhang X, (2011) Phenylketonuria-related synaptic changes in a BTBR-Pah(enu2) mouse model. Neuroreport 22 (12): 617-622.
    • (2011) Neuroreport , vol.22 , Issue.12 , pp. 617-622
    • Liang, L.1    Gu, X.2    Lu, L.3    Li, D.4    Zhang, X.5
  • 14
    • 0038439345 scopus 로고    scopus 로고
    • The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria
    • Cabib S, Pascucci T, Ventura R, Romano V, Puglisi-Allegra S, (2003) The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria. Behav Genet 33 (3): 301-310.
    • (2003) Behav Genet , vol.33 , Issue.3 , pp. 301-310
    • Cabib, S.1    Pascucci, T.2    Ventura, R.3    Romano, V.4    Puglisi-Allegra, S.5
  • 15
    • 0036257999 scopus 로고    scopus 로고
    • Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by Phenylalaninenylalanine at concentrations observed during phenylketonuria
    • Glushakov AV, Dennis DM, Morey TE, Sumners C, Cucchiara RF, et al. (2002) Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by Phenylalaninenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry 7 (4): 359-367.
    • (2002) Mol Psychiatry , vol.7 , Issue.4 , pp. 359-367
    • Glushakov, A.V.1    Dennis, D.M.2    Morey, T.E.3    Sumners, C.4    Cucchiara, R.F.5
  • 16
    • 0037381514 scopus 로고    scopus 로고
    • Phenylalaninenylalanine selectively depresses currents at glutamatergic excitatory synapses
    • Glushakov AV, Dennis DM, Sumners C, Seubert CN, Martynyuk AE, (2003) Phenylalaninenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res 72 (1): 116-124.
    • (2003) J Neurosci Res , vol.72 , Issue.1 , pp. 116-124
    • Glushakov, A.V.1    Dennis, D.M.2    Sumners, C.3    Seubert, C.N.4    Martynyuk, A.E.5
  • 18
    • 0037452854 scopus 로고    scopus 로고
    • Glutamate receptor function in learning and memory
    • Riedel G, Platt B, Micheau J, (2003) Glutamate receptor function in learning and memory. Behavioural Brain Res 140: 1-47.
    • (2003) Behavioural Brain Res , vol.140 , pp. 1-47
    • Riedel, G.1    Platt, B.2    Micheau, J.3
  • 19
    • 0024455878 scopus 로고
    • Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5
    • Morris RG, (1989) Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci 9 (9): 3040-3057.
    • (1989) J Neurosci , vol.9 , Issue.9 , pp. 3040-3057
    • Morris, R.G.1
  • 20
    • 0025333815 scopus 로고
    • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding
    • Yeh GC, Bonhaus DW, McNamara JO, (1990) Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. Mol Pharmacol 38 (1): 14-19.
    • (1990) Mol Pharmacol , vol.38 , Issue.1 , pp. 14-19
    • Yeh, G.C.1    Bonhaus, D.W.2    McNamara, J.O.3
  • 22
    • 0028096701 scopus 로고
    • Pharmacological evidence for a role of long-term potentiation in memory
    • Izquierdo I, (1994) Pharmacological evidence for a role of long-term potentiation in memory. FASEB J 8: 1139-1145.
    • (1994) FASEB J , vol.8 , pp. 1139-1145
    • Izquierdo, I.1
  • 24
    • 0020047461 scopus 로고
    • A study of placental transfer mechanisms in nonhuman primates using [14C]phenylalanine
    • Pueschel SM, Boylan JM, Jackson BT, Piasecki GJ, (1982) A study of placental transfer mechanisms in nonhuman primates using [14C]phenylalanine. Obstet Gynecol 59 (2): 182-188.
    • (1982) Obstet Gynecol , vol.59 , Issue.2 , pp. 182-188
    • Pueschel, S.M.1    Boylan, J.M.2    Jackson, B.T.3    Piasecki, G.J.4
  • 25
    • 0019613682 scopus 로고
    • Letters to the Editor: Aspartame doses for Phenylketonuria
    • Stegink LD, Filer LJ Jr, BakerGL, McDonnell JE, (1981) Letters to the Editor: Aspartame doses for Phenylketonuria. J Nutr 111 (9): 1688-1690.
    • (1981) J Nutr , vol.111 , Issue.9 , pp. 1688-1690
    • Stegink, L.D.1    Filer Jr., L.J.2    Baker, G.L.3    McDonnell, J.E.4
  • 26
    • 0024454434 scopus 로고
    • Impaired performance on odor-aversion testing following prenatal aspartame exposure in the guinea pig
    • Dow-Edwards DL, Scribani LA, Riley EP, (1989) Impaired performance on odor-aversion testing following prenatal aspartame exposure in the guinea pig. Neurotoxicol Teratol 11 (4): 413-416.
    • (1989) Neurotoxicol Teratol , vol.11 , Issue.4 , pp. 413-416
    • Dow-Edwards, D.L.1    Scribani, L.A.2    Riley, E.P.3
  • 27
    • 0018663154 scopus 로고
    • Aspartame: assessment of developmental psychotoxicity of a new artificial sweetener
    • Brunner RL, Vorhees CV, Kinney L, Butcher RE, (1979) Aspartame: assessment of developmental psychotoxicity of a new artificial sweetener. Neurobehav Toxicol 1 (1): 79-86.
    • (1979) Neurobehav Toxicol , vol.1 , Issue.1 , pp. 79-86
    • Brunner, R.L.1    Vorhees, C.V.2    Kinney, L.3    Butcher, R.E.4
  • 28
    • 80052859721 scopus 로고    scopus 로고
    • Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia, Food Chem Toxicol
    • Kim JY, Seo J, Cho KH, (2011) Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia, Food Chem Toxicol. 49 (11): 2899-905.
    • (2011) , vol.49 , Issue.11 , pp. 2899-2905
    • Kim, J.Y.1    Seo, J.2    Cho, K.H.3
  • 29
    • 0025826053 scopus 로고
    • Effects of acute aspartame and acute alcohol ingestion upon the cognitive performance of pilots
    • Stokes AF, Belger A, Banich MT, Taylor H, (1991) Effects of acute aspartame and acute alcohol ingestion upon the cognitive performance of pilots. Aviat Space Environ Med 62 (7): 648-653.
    • (1991) Aviat Space Environ Med , vol.62 , Issue.7 , pp. 648-653
    • Stokes, A.F.1    Belger, A.2    Banich, M.T.3    Taylor, H.4
  • 30
    • 0026008179 scopus 로고
    • High doses of aspartame have no effects on sensorimotor function or learning and memory in rats
    • Tilson HA, Hong JS, Sobotka TJ, (1991) High doses of aspartame have no effects on sensorimotor function or learning and memory in rats. Neurotoxicol Teratol 13 (1): 27-35.
    • (1991) Neurotoxicol Teratol , vol.13 , Issue.1 , pp. 27-35
    • Tilson, H.A.1    Hong, J.S.2    Sobotka, T.J.3
  • 31
    • 0023217946 scopus 로고
    • Effect of excess intracranial amino acids on memory: a behavioural survey
    • Gibbs ME, Richdale AL, Ng KT, (1987) Effect of excess intracranial amino acids on memory: a behavioural survey. Neurosci Biobehav Rev 11 (3): 331-339.
    • (1987) Neurosci Biobehav Rev , vol.11 , Issue.3 , pp. 331-339
    • Gibbs, M.E.1    Richdale, A.L.2    Ng, K.T.3
  • 32
    • 0023936362 scopus 로고
    • Development of hypothalamic obesity in growing rats
    • Remke H, Wilsdorf A, Müller F, (1988) Development of hypothalamic obesity in growing rats. Exp Pathol 33 (4): 223-232.
    • (1988) Exp Pathol , vol.33 , Issue.4 , pp. 223-232
    • Remke, H.1    Wilsdorf, A.2    Müller, F.3
  • 33
    • 33645814388 scopus 로고    scopus 로고
    • Obesity, voracity, and short stature: the impact of glutamate on the regulation of appetite
    • Hermanussen M, García AP, Sunder M, Voight M, Salazar V, et al. (2006) Obesity, voracity, and short stature: the impact of glutamate on the regulation of appetite. Eur J Clin Nutr 60 (1): 25-31.
    • (2006) Eur J Clin Nutr , vol.60 , Issue.1 , pp. 25-31
    • Hermanussen, M.1    García, A.P.2    Sunder, M.3    Voight, M.4    Salazar, V.5
  • 34
    • 55449128579 scopus 로고    scopus 로고
    • Comparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and/or the high fat diet feeding in C57BL/6 and NMRI mice
    • Matysková R, Maletínská L, Maixnerová J, Pirník Z, Kiss A, et al. (2008) Comparison of the obesity phenotypes related to monosodium glutamate effect on arcuate nucleus and/or the high fat diet feeding in C57BL/6 and NMRI mice. Physiol Res 57 (5): 727-734.
    • (2008) Physiol Res , vol.57 , Issue.5 , pp. 727-734
    • Matysková, R.1    Maletínská, L.2    Maixnerová, J.3    Pirník, Z.4    Kiss, A.5
  • 35
    • 0018241231 scopus 로고
    • Models of neuroendocrine regulation: use of monosodium glutamate as an investigational tool
    • Nemeroff CB, Lipton MA, Kizer JS, (1978) Models of neuroendocrine regulation: use of monosodium glutamate as an investigational tool. Dev Neurosci 1 (2): 102-109.
    • (1978) Dev Neurosci , vol.1 , Issue.2 , pp. 102-109
    • Nemeroff, C.B.1    Lipton, M.A.2    Kizer, J.S.3
  • 36
    • 0014937190 scopus 로고
    • Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine
    • Olney JW, Ho OL, (1970) Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature 227: 609-610.
    • (1970) Nature , vol.227 , pp. 609-610
    • Olney, J.W.1    Ho, O.L.2
  • 38
    • 0031058402 scopus 로고    scopus 로고
    • Effects of maternal oral administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain. Brain Res
    • Yu T, Zhao Y, Shi W, Ma R, Yu L, (1997) Effects of maternal oral administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain. Brain Res. 747 (2): 195-206.
    • (1997) , vol.747 , Issue.2 , pp. 195-206
    • Yu, T.1    Zhao, Y.2    Shi, W.3    Ma, R.4    Yu, L.5
  • 39
    • 0343720082 scopus 로고
    • L-glutamic acid and its ammonium, calcium, monosodium and potassium salts
    • Joint Food and Agriculture Organization/World Health Organization (FAO/WHO) Expert Committee on Food Additives (JECFA), WHO Food Additives series 22, 97-161 New York Cambridge University Press
    • Joint Food and Agriculture Organization/World Health Organization (FAO/WHO) Expert Committee on Food Additives (JECFA) (1988): L-glutamic acid and its ammonium, calcium, monosodium and potassium salts. WHO Food Additives series 22 97-161 New York Cambridge University Press.
    • (1988)
  • 40
    • 74349108947 scopus 로고    scopus 로고
    • Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory
    • Collison KS, Makhoul NJ, Inglis A, Al-Johi M, Zaidi MZ, et al. (2010) Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory. Physiol Behav 99 (3): 334-342.
    • (2010) Physiol Behav , vol.99 , Issue.3 , pp. 334-342
    • Collison, K.S.1    Makhoul, N.J.2    Inglis, A.3    Al-Johi, M.4    Zaidi, M.Z.5
  • 41
    • 0345045525 scopus 로고    scopus 로고
    • Neonatal stress alters habituation of exploratory behavior in adult male but not female rats
    • Dubovický M, Skultétyová I, Jezová D, (1999) Neonatal stress alters habituation of exploratory behavior in adult male but not female rats. Pharmacol Biochem Behav 64 (4): 681-686.
    • (1999) Pharmacol Biochem Behav , vol.64 , Issue.4 , pp. 681-686
    • Dubovický, M.1    Skultétyová, I.2    Jezová, D.3
  • 42
    • 0025972319 scopus 로고
    • Neonatal treatment with monosodium glutamate: effects of prolonged growth hormone (GH)-releasing hormone deficiency on pulsatile GH secretion and growth in female rats
    • Maiter D, Underwood LE, Martin JB, Koenig JI, (1991) Neonatal treatment with monosodium glutamate: effects of prolonged growth hormone (GH)-releasing hormone deficiency on pulsatile GH secretion and growth in female rats. Endocrinology 128 (2): 1100-1106.
    • (1991) Endocrinology , vol.128 , Issue.2 , pp. 1100-1106
    • Maiter, D.1    Underwood, L.E.2    Martin, J.B.3    Koenig, J.I.4
  • 43
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and ß-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC, (1985) Homeostasis model assessment: insulin resistance and ß-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 44
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris RJ, (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.J.1
  • 45
    • 30444454374 scopus 로고    scopus 로고
    • Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
    • Brody DL, Holtzman DM, (2006) Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Exp Neurol 197 (2): 330-340.
    • (2006) Exp Neurol , vol.197 , Issue.2 , pp. 330-340
    • Brody, D.L.1    Holtzman, D.M.2
  • 46
    • 67849089031 scopus 로고    scopus 로고
    • Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium L-glutamate-obesity in mice
    • Andreazzi AE, Scomparin DX, Mesquita FP, Balbo SL, Gravena C, et al. (2009) Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium L-glutamate-obesity in mice. J Endocrinol 201 (3): 351-9.
    • (2009) J Endocrinol , vol.201 , Issue.3 , pp. 351-359
    • Andreazzi, A.E.1    Scomparin, D.X.2    Mesquita, F.P.3    Balbo, S.L.4    Gravena, C.5
  • 47
    • 0019029864 scopus 로고
    • Biological properties of aspartame. I. Evaluation of central nervous system effects
    • Potts WJ, Bloss JL, Nutting EF, (1980) Biological properties of aspartame. I. Evaluation of central nervous system effects. Environ Pathol Toxicol 3 (5-6): 341-345.
    • (1980) Environ Pathol Toxicol , vol.3 , Issue.5-6 , pp. 341-345
    • Potts, W.J.1    Bloss, J.L.2    Nutting, E.F.3
  • 48
    • 0017055661 scopus 로고
    • Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: a preliminary report
    • Reynolds WA, Butler V, Lemkey-Johnston N, (1976) Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: a preliminary report. Toxicol Environ Health 2 (2): 471-80.
    • (1976) Toxicol Environ Health , vol.2 , Issue.2 , pp. 471-480
    • Reynolds, W.A.1    Butler, V.2    Lemkey-Johnston, N.3
  • 49
    • 0021248304 scopus 로고
    • Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydroxyindoles
    • Yokogoshi H, Roberts CH, Caballero B, Wurtman RJ, (1984) Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydroxyindoles. Am J Clin Nutr 40 (1): 1-7.
    • (1984) Am J Clin Nutr , vol.40 , Issue.1 , pp. 1-7
    • Yokogoshi, H.1    Roberts, C.H.2    Caballero, B.3    Wurtman, R.J.4
  • 50
    • 0033514946 scopus 로고    scopus 로고
    • Phenylketonuria: old disease, new approach to treatment [editorial]
    • Levy HL, (1999) Phenylketonuria: old disease, new approach to treatment [editorial]. Proc Natl Acad Sci USA 96, 1811-1813.
    • (1999) Proc Natl Acad Sci USA 96, , pp. 1811-1813
    • Levy, H.L.1
  • 52
    • 0015523857 scopus 로고
    • Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception. Biochem Biophys Acta
    • Tourian A, Treiman DM, Carr JS, (1972) Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception. Biochem Biophys Acta. 279(3), 484-490.
    • (1972) 279(3), , pp. 484-490
    • Tourian, A.1    Treiman, D.M.2    Carr, J.S.3
  • 54
    • 0029900264 scopus 로고    scopus 로고
    • The Activity of the Highly Inducible Mouse Phenylalanine Hydroxylase Gene Promoter Is Dependent upon a Tissue-Specific, Hormone-Inducible Enhancer
    • Faust DM, Catherin A-M, Barbaux S, Belkadi L, Imaizumi-Scherrer T, et al. (1996) The Activity of the Highly Inducible Mouse Phenylalanine Hydroxylase Gene Promoter Is Dependent upon a Tissue-Specific, Hormone-Inducible Enhancer. Mol Cell Biol 16 (6); 3125-3137.
    • (1996) Mol Cell Biol 16 (6); , pp. 3125-3137
    • Faust, D.M.1    Catherin, A.-M.2    Barbaux, S.3    Belkadi, L.4    Imaizumi-Scherrer, T.5
  • 55
    • 0038439345 scopus 로고    scopus 로고
    • The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria. Behav Genet
    • Cabib S, Pascucci T, Ventura R, Romano V, Puglisi-Allegra S, (2003) The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria. Behav Genet. 33 (3): 301-10.
    • (2003) , vol.33 , Issue.3 , pp. 301-310
    • Cabib, S.1    Pascucci, T.2    Ventura, R.3    Romano, V.4    Puglisi-Allegra, S.5
  • 56
    • 0033565404 scopus 로고    scopus 로고
    • Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation. J Neurosci
    • Zagreda L, Goodman J, Druin DP, McDonald D, Diamond A, (1999) Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation. J Neurosci. 19 (14): 6175-82.
    • (1999) , vol.19 , Issue.14 , pp. 6175-6182
    • Zagreda, L.1    Goodman, J.2    Druin, D.P.3    McDonald, D.4    Diamond, A.5
  • 57
    • 21244501270 scopus 로고    scopus 로고
    • Cognitive functions in classic phenylketonuria and mild hyperphenylalaninaemia: experience in a paediatric population. Dev Med Child Neurol
    • Gassió R, Artuch R, Vilaseca MA, Fusté E, Boix C, et al. (2005) Cognitive functions in classic phenylketonuria and mild hyperphenylalaninaemia: experience in a paediatric population. Dev Med Child Neurol. 47 (7): 443-8.
    • (2005) , vol.47 , Issue.7 , pp. 443-448
    • Gassió, R.1    Artuch, R.2    Vilaseca, M.A.3    Fusté, E.4    Boix, C.5
  • 58
    • 72249106864 scopus 로고    scopus 로고
    • Beyond executive function: non-executive cognitive abilities in individuals with PKU. Mol Genet Metab
    • Janzen D, Nguyen M, (2010) Beyond executive function: non-executive cognitive abilities in individuals with PKU. Mol Genet Metab. 99 (Suppl 1): S47-51.
    • (2010) , vol.99 , Issue.SUPPL. 1
    • Janzen, D.1    Nguyen, M.2
  • 60
    • 83655163810 scopus 로고    scopus 로고
    • Regular exercise prevents oxidative stress in the brain of hyperphenylalaninemic rats
    • Mazzola PN, Terra M, Rosa AP, Mescka CP, Moraes TB, et al. (2011) Regular exercise prevents oxidative stress in the brain of hyperphenylalaninemic rats. Metab Brain Dis 26 (4): 291-7.
    • (2011) Metab Brain Dis , vol.26 , Issue.4 , pp. 291-297
    • Mazzola, P.N.1    Terra, M.2    Rosa, A.P.3    Mescka, C.P.4    Moraes, T.B.5
  • 61
    • 8444241138 scopus 로고    scopus 로고
    • Cognitive reserve and the neurobiology of cognitive aging. Ageing Res Rev
    • Whalley LJ, Deary IJ, Appleton CL, Starr JM, (2004) Cognitive reserve and the neurobiology of cognitive aging. Ageing Res Rev. 3 (4): 369-82.
    • (2004) , vol.3 , Issue.4 , pp. 369-382
    • Whalley, L.J.1    Deary, I.J.2    Appleton, C.L.3    Starr, J.M.4
  • 62
    • 84859231558 scopus 로고    scopus 로고
    • Effect of Aspartame on Oxidative Stress and Monoamine Neurotransmitter Levels in Lipopolysaccharide-Treated Mice
    • Neurotox Res. Aug 6. [Epub ahead of print]
    • Abdel-Salam OM, Salem NA, Hussein JS, (2011) Effect of Aspartame on Oxidative Stress and Monoamine Neurotransmitter Levels in Lipopolysaccharide-Treated Mice. Neurotox Res. Aug 6. [Epub ahead of print].
    • (2011)
    • Abdel-Salam, O.M.1    Salem, N.A.2    Hussein, J.S.3
  • 63
    • 0037112316 scopus 로고    scopus 로고
    • Differential learning abilities of 129T2/Sv and C57BL/6J mice as assessed in three water maze protocols
    • Wolff M, Savova M, Malleret G, Segu L, Buhot MC, (2002) Differential learning abilities of 129T2/Sv and C57BL/6J mice as assessed in three water maze protocols. Behav Brain Res 136 (2): 463-474.
    • (2002) Behav Brain Res , vol.136 , Issue.2 , pp. 463-474
    • Wolff, M.1    Savova, M.2    Malleret, G.3    Segu, L.4    Buhot, M.C.5
  • 65
    • 0033119117 scopus 로고    scopus 로고
    • Parallel information processing in the dorsal striatum: relation to hippocampal function
    • Devan BD, White NM, (1999) Parallel information processing in the dorsal striatum: relation to hippocampal function. J Neurosci 19 (7): 2789-2798.
    • (1999) J Neurosci , vol.19 , Issue.7 , pp. 2789-2798
    • Devan, B.D.1    White, N.M.2
  • 66
    • 0014055559 scopus 로고
    • Evaluation of enhanced thigmotaxis as a condition of impaired maze learning by rats with hippocampal lesions. J Comp Physiol Psychol
    • Hostetter G, Thomas GJ, (1967) Evaluation of enhanced thigmotaxis as a condition of impaired maze learning by rats with hippocampal lesions. J Comp Physiol Psychol 63 (1): 105-110.
    • (1967) , vol.63 , Issue.1 , pp. 105-110
    • Hostetter, G.1    Thomas, G.J.2
  • 67
    • 0030057656 scopus 로고    scopus 로고
    • Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits
    • Cain DP, Saucier D, Hall J, Hargreaves EL, Boon F, (1996) Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits. Behav Neurosci 110 (1): 86-102.
    • (1996) Behav Neurosci , vol.110 , Issue.1 , pp. 86-102
    • Cain, D.P.1    Saucier, D.2    Hall, J.3    Hargreaves, E.L.4    Boon, F.5
  • 68
    • 0030067179 scopus 로고    scopus 로고
    • Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: nonspatial pretraining eliminates spatial learning deficits
    • Saucier D, Hargreaves EL, Boon F, Vanderwolf CH, Cain DP, (1996) Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: nonspatial pretraining eliminates spatial learning deficits. Behav Neurosci 110 (1): 103-116.
    • (1996) Behav Neurosci , vol.110 , Issue.1 , pp. 103-116
    • Saucier, D.1    Hargreaves, E.L.2    Boon, F.3    Vanderwolf, C.H.4    Cain, D.P.5
  • 69
    • 0021602834 scopus 로고
    • Reflex responsiveness of CF-1 mouse neonates following maternal aspartame exposure
    • Mahalik MP, Gautieri RF, (1984) Reflex responsiveness of CF-1 mouse neonates following maternal aspartame exposure. Res Commun Psychol Psychiatry Behav 9: 385-403.
    • (1984) Res Commun Psychol Psychiatry Behav , vol.9 , pp. 385-403
    • Mahalik, M.P.1    Gautieri, R.F.2
  • 72
    • 0019484119 scopus 로고
    • Toxicity of aspartame and its diketopiperazine for Wistar rats by dietary administration for 104 weeks, Toxicology
    • Ishii H, Koshimizu T, Usami S, Fujimoto T, (1981) Toxicity of aspartame and its diketopiperazine for Wistar rats by dietary administration for 104 weeks, Toxicology 21 (2): 91-94.
    • (1981) , vol.21 , Issue.2 , pp. 91-94
    • Ishii, H.1    Koshimizu, T.2    Usami, S.3    Fujimoto, T.4
  • 73
    • 77957329681 scopus 로고    scopus 로고
    • Gain weight by going diet? Artificial Sweeteners and the Neurobiology of Sugar Cravings: Neuroscience
    • Yang Q, (2010) Gain weight by "going diet? " Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience, Yale J Biol Med 83 (2): 101-108.
    • (2010) Yale J Biol Med , vol.83 , Issue.2 , pp. 101-108
    • Yang, Q.1
  • 74
  • 75
    • 34447134707 scopus 로고    scopus 로고
    • Is aspartame really safer in reducing the risk of hypoglycemia during exercise in patients with type 2 diabetes?
    • Ferland A, Brassard P, Poirier P, (2007) Is aspartame really safer in reducing the risk of hypoglycemia during exercise in patients with type 2 diabetes?. Diabetes Care 30 (7): e59.
    • (2007) Diabetes Care , vol.30 , Issue.7
    • Ferland, A.1    Brassard, P.2    Poirier, P.3
  • 76
    • 20444421299 scopus 로고    scopus 로고
    • Behavioral deficits in adult rats treated neonatally with glutamate
    • Hlinák Z, Gandalovicová D, Krejcí I, (2005) Behavioral deficits in adult rats treated neonatally with glutamate. Neurotoxicol Teratol 27 (3): 465-473.
    • (2005) Neurotoxicol Teratol , vol.27 , Issue.3 , pp. 465-473
    • Hlinák, Z.1    Gandalovicová, D.2    Krejcí, I.3
  • 77
    • 0026048853 scopus 로고
    • Effect of monosodium glutamate treatment during neonatal development on lipogenesis rate and lipoprotein lipase activity in adult rats. Biochem Int
    • Nascimento Curi CM, Marmo MR, Egami M, Ribeiro EB, Andrade IS, et al. (1991) Effect of monosodium glutamate treatment during neonatal development on lipogenesis rate and lipoprotein lipase activity in adult rats. Biochem Int. 24 (5): 927-35.
    • (1991) , vol.24 , Issue.5 , pp. 927-935
    • Nascimento, C.C.M.1    Marmo, M.R.2    Egami, M.3    Ribeiro, E.B.4    Andrade, I.S.5
  • 78
    • 34147119059 scopus 로고    scopus 로고
    • Metabolic syndrome and cognitive decline
    • Yaffe K, (2007) Metabolic syndrome and cognitive decline. Curr Alzheimer Res; 4 (2): 123-6.
    • (2007) Curr Alzheimer Res; , vol.4 , Issue.2 , pp. 123-126
    • Yaffe, K.1
  • 79
    • 2542622162 scopus 로고    scopus 로고
    • Search strategies used by APP transgenic mice during navigation in the Morris water maze
    • Janus C, (2004) Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learn Mem; 11 (3): 337-46.
    • (2004) Learn Mem; , vol.11 , Issue.3 , pp. 337-346
    • Janus, C.1
  • 80
    • 50449105836 scopus 로고    scopus 로고
    • Diet-induced obesity and spatial cognition in young male rats
    • Jurdak N, Lichtenstein AH, Kanarek RB, (2008) Diet-induced obesity and spatial cognition in young male rats. Nutr Neurosci. 11 (2): 48-54.
    • (2008) Nutr Neurosci , vol.11 , Issue.2 , pp. 48-54
    • Jurdak, N.1    Lichtenstein, A.H.2    Kanarek, R.B.3
  • 81
    • 29744455297 scopus 로고    scopus 로고
    • Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity
    • Benice TS, Rizk A, Kohama S, Pfankuch T, Raber J, (2006) Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137 (2): 413-23.
    • (2006) Neuroscience , vol.137 , Issue.2 , pp. 413-423
    • Benice, T.S.1    Rizk, A.2    Kohama, S.3    Pfankuch, T.4    Raber, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.