Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice

Toxicology Letters

Volumn 115, Issue 2, 2000, Pages 117-125

  Park, Cheol Hyoung ^a   Choi, Se Hoon ^a   Piao, Yongde ^a   Kim, Seong Hun ^a   Lee, Young Jae ^b   Kim, Hye Sun ^a   Jeong, Sung Jin ^a   Rah, Jong Cheol ^a   Seo, Ji Heui ^a   Lee, Jun Ho ^a   Chang, Keun A ^a   Jung, Young Ja ^c   Suh, Yoo Hun ^a  

^a Neuroscience Research Institute   (South Korea)

^b Jeju National University   (South Korea)

^c Korea Food and Drug Administration   (South Korea)

Author keywords

Aspartate; Histopathology; Learning and memory; Monosodium glutamate; Passive avoidance

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DOSE RESPONSE; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOTHALAMUS; LEARNING; MALE; MEMORY CONSOLIDATION; MOTOR ACTIVITY; MOUSE; NERVE CELL LESION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; TAIL FLICK TEST; WEIGHT REDUCTION;

ANIMALS; ASPARTIC ACID; FOOD ADDITIVES; HYPOTHALAMUS; INFUSIONS, PARENTERAL; MALE; MAZE LEARNING; MEMORY; MICE; NEURONS; SODIUM GLUTAMATE;

ANIMALIA;

EID: 0342313567     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(00)00188-0     Document Type: Article

References (33)

1. Airoldi L.M., Bonfanti P., Ghezzi M., Salmona M., Garattini S. Effects of oral monosodium glutamate on glutamic acid levels in the nucleus arcuatus of the hypothalamus and on serum osmolarity of adult and infant mice. Toxicol. Lett. 7:1980;107-111.
2. Bartus R.T., Dean R.L., Beer R.L.D., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-417.
3. Bogdanov M.B., Wurtman R.J. Effects of systemic or oral ad libitum monosodium glutamate administration on striatal glutamate release, as measured using microdialysis in freely moving rats. Brain Res. 660:1994;337-340.
4. Carson K.A., Nemeroff C.B., Rone M.S., Young-Blood W.W., Prange A.J. Jr, Hanker J.S. Biochemical and histochemical evidence for the existence of a tuberoinfundibular cholinergic pathway in the rat. Brain Res. 129:1977;169-173.
5. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
6. Cooper J.R. Unsolved problems in the cholinergic nervous system. J. Neurochem. 63:1994;395-399.
7. Cotman C.W., Monaghan D.T., Ottersen O.P., Storm-Mathisen J. Anatomical organization of excitatory amino receptors and their pathways. Trends Neurosci. 10:1987;273-280.
8. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegerative disorders. Science. 262:1993;689-695.
9. Gao J., Wu J., Zhao X.N., Zhang W.N., Zhang Y.Y., Zhang Z.X. Transplacental neurotoxic effects of monosodium glutamate on structures and functions of specific brain areas of filial mice. Sheng Li Hsueh Pao. 46:1994;44-51.
10. Ghanta V.K., Rogers C.F., Hsueh C.M., Demissie S., Lorden J.F., Hiramoto N.S., Hiramoto R.N. Role of arcuate nucleus of the hypothalamus in the acquisition of association memory between the CS and US. J. Neuroimmunol. 50:1994;109-114.
11. Harris L.S., Pierson A.K. Some narcortic antagonists in the benzomorphan series. J. Pharmacol. Exp. Ther. 143:1964;141-148.
12. Jarrard L.E. On the role of the hippocampus in learning and memory in the rat. Behav. Neural Biol. 60:1993;9-26.
13. Karlsen R.L., Fonnum F. The toxic effect of sodium glutamate on rat retina: changes in putative transmitters and their corresponding enzymes. J. Neurochem. 27:1976;1437-1441.
14. Lisman J.E. Relating hippocampal circuitry to function: recall of memory sequences by reciprocal dentate-CA3 interactions. Neuron. 22:1999;233-242.
15. McDonald J.W., Silverstein F.S., Johnston M.V. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system. Brain Res. 459:1988;200-203.
16. Meldrum B. Amino acids as dietary excitotoxins: a contribution to understanding neurodegenerative disorders. Brain Res. Rev. 18:1993;293-314.
17. Monno A., Vezzani A., Bastone A., Salmona M., Garattini S. Extracellular glutamate levels in the hypothalamus and hippocampus of rats after acute or chronic oral intake of monosodium glutamate. Neurosci. Lett. 193:1995;45-48.
18. Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 164:1969;719-721.
19. Olney J.W. Excitotoxins in foods. Neurotoxicology. 15:1994;535-544.
20. Olney J.W., Ho O.L. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature. 227:1970;609-611.
21. Olney J.W., Labruyere J., DeGubareff T. Brain damage in mice from voluntary ingestion of glutamate and aspartate. Neurobehav. Toxicol. 2:1980;125-129.
22. Perl T.M., Bedard L., Kosatsky T., Hockin J.C., Todd E.C.D., Remis R.S. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N. Engl. J. Med. 322:1990;1775-1780.
23. (1S,3R) attenuate learning in a Morris water maze paradigm. Neurosci. Lett. 178:1994;43-46.
24. Price M.C., Olney J.W., Cicero T.J. Acute elevations of serum luteinizing hormone induced by kainic acid, N-methylaspartic acid or homocysteic acid. Neuroendocrinology. 26:1978;352-358.
25. Rao Z.R., Yamano M., Wanaka A., Tatehata T., Shiosaka S., Tohyama M. Distribution of cholinergic neurons and fibers in the hypothalamus of the rat using choline acetyltransferase as a marker. Neuroscience. 20:1987;923-934.
26. Redding T.W., Schally A.V., Arimura A., Wakabayashi I. Effects of monosodium glutamate on some endocrine functions. Neuroendocrinology. 8:1971;245-255.
27. Reynolds W.A., Butler V., Lemkey-Johnston M. Hypothalamic morphology following ingestion of aspartame or MSG in the neonatal rodent and primate: a preliminary report. J. Toxicol. Environ. Health. 2:1976;471-480.
28. Riedel, Wetzel, G.W., Kozikowski, A.P., Reymann, K.G., 1995. Block of spatial learning by mGluR agonist tADA in rats. Neuropharmacology 34, 559-561.
29. Shen Z., Wang G., Lin S.Z. Two-way shuttle box avoidance conditioning and brain NADH in rats. Physiol. Behav. 48:1990;515-517.
30. Summers M.J., Crowe S.F., Ng K.T. Administration of glutamate following a eminder induces transient memory loss in day-old chicks. Cogn. Brain Res. 3:1995;1-8.
31. Thomas R.J. Excitatory amino acids in health and disease. J. Am. Geriatr. Soc. 43:1995;1279-1289.
32. Whetsell W.O. Jr Current concepts of excitotoxicity. J. Neuropathol. Exp. Neurol. 55:1996;1-13.
33. Woody C.D., Kim E.H.-J., Berthier N.E. Effects of hypothalamic stimulation on unit responses recorded from neurons of sensorimotor cortex of awake cats during conditioning. J. Neurophysiol. 49:1983;780-791.