Nuclear factor kappa b activation occurs in the amnion prior to labour onset and modulates the expression of numerous labour associated genes

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Lim, Sheri ^a   MacIntyre, David A ^a   Lee, Yun S ^a   Khanjani, Shirin ^a   Terzidou, Vasso ^a   Teoh, T G ^b   Bennett, Phillip R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 8; OXYTOCIN RECEPTOR; SYNAPTOTAGMIN I; THROMBOSPONDIN; TRANSCRIPTION FACTOR RELA; CYTOKINE; PLACENTA PROTEIN; TRANSCRIPTION FACTOR RELB;

AMNION; ARTICLE; CELL CYCLE; CELL DEATH; CELL STRUCTURE; CESAREAN SECTION; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; LABOR; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; UPREGULATION; CELL NUCLEUS; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; LABOR ONSET; METABOLISM; PREGNANCY; PROTEIN BINDING; SIGNAL TRANSDUCTION;

AMNION; CELL NUCLEUS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; LABOR ONSET; LABOR, OBSTETRIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; PREGNANCY PROTEINS; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB;

EID: 84859238565     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034707     Document Type: Article

References (45)

1. Okita JR, MacDonald PC, Johnston JM, (1982) Mobilization of arachidonic acid from specific glycerophospholipids of human fetal membranes during early labor. J Biol Chem 257: 14029-14034.
2. Okita JR, Sagawa N, Casey ML, Snyder JM, (1983) A comparison of human amnion tissue and amnion cells in primary culture by morphological and biochemical criteria. In Vitro 19: 117-126.
3. Bennett PR, Elder MG, (1992) The mechanisms of preterm labour; the interaction between amnion cells and leukocytes in the metabolism of arachidonic acid. Prostaglandins 43: 87-98.
4. Sangha RK, Walton JC, Ensor CM, Tai HH, Challis JR, (1994) Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor. J Clin Endocrinol Metab 78: 982-989.
5. Sadovsky Y, Nelson DM, Muglia LJ, Gross GA, Harris KC, et al. (2000) Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2. Am J Obstet Gynecol 182: 370-376.
6. Sawdy RJ, Slater DM, Dennes WJ, Sullivan MH, Bennett PR, (2000) The roles of the cyclo-oxygenases types one and two in prostaglandin synthesis in human fetal membranes at term. Placenta 21: 54-57.
7. Slater D, Dennes W, Sawdy R, Allport V, Bennett P, (1999) Expression of cyclo-oxygenase types-1 and-2 in human fetal membranes throughout pregnancy. J Mol Endocrinol 22: 125-130.
8. Slater DM, Berger LC, Newton R, Moore GE, Bennett PR, (1995) Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term. Am J Obstet Gynecol 172: 77-82.
9. Elliott CL, Loudon JA, Brown N, Slater DM, Bennett PR, et al. (2001) IL-1beta and IL-8 in human fetal membranes: changes with gestational age, labor, and culture conditions. Am J Reprod Immunol 46: 260-267.
10. Junqueira LC, Zugaib M, Montes GS, Toledo OM, Krisztan RM, et al. (1980) Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilation. Am J Obstet Gynecol 138: 273-281.
11. Thomson AJ, Telfer JF, Young A, Campbell S, Stewart CJ, et al. (1999) Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum Reprod 14: 229-236.
12. Osmers R, Rath W, Adelmann-Grill BC, Fittkow C, Kuloczik M, et al. (1992) Origin of cervical collagenase during parturition. Am J Obstet Gynecol 166: 1455-1460.
13. Allport VC, Pieber D, Slater DM, Newton R, White JO, et al. (2001) Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'. Mol Hum Reprod 7: 581-586.
14. Elliott CL, Allport VC, Loudon JA, Wu GD, Bennett PR, (2001) Nuclear factor-kappa B is essential for up-regulation of interleukin-8 expression in human amnion and cervical epithelial cells. Mol Hum Reprod 7: 787-790.
15. Belt AR, Baldassare JJ, Molnar M, Romero R, Hertelendy F, (1999) The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells. Am J Obstet Gynecol 181: 359-366.
16. Croston GE, Cao Z, Goeddel DV, (1995) NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity. J Biol Chem 270: 16514-16517.
17. Lee Y, Allport V, Sykes A, Lindstrom T, Slater D, et al. (2003) The effects of labour and of interleukin 1 beta upon the expression of nuclear factor kappa B related proteins in human amnion. Mol Hum Reprod 9: 213-218.
18. Fan CM, Maniatis T, (1991) Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway. Nature 354: 395-398.
19. Ishikawa H, Claudio E, Dambach D, Raventos-Suarez C, Ryan C, et al. (1998) Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50. J Exp Med 187: 985-996.
20. Lindstrom TM, Bennett PR, (2005) The role of nuclear factor kappa B in human labour. Reproduction 130: 569-581.
21. Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, et al. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol Cell Biol 15: 2809-2818.
22. Huang TT, Kudo N, Yoshida M, Miyamoto S, (2000) A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci U S A 97: 1014-1019.
23. Huang TT, Miyamoto S, (2001) Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha. Mol Cell Biol 21: 4737-4747.
24. Lee SH, Hannink M, (2002) Characterization of the nuclear import and export functions of Ikappa B(epsilon). J Biol Chem 277: 23358-23366.
25. Bennett PR, Slater D, Sullivan M, Elder MG, Moore GE, (1993) Changes in amniotic arachidonic acid metabolism associated with increased cyclo-oxygenase gene expression. Br J Obstet Gynaecol 100: 1037-1042.
26. Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, et al. (1992) I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Genes Dev 6: 745-760.
27. Weih F, Carrasco D, Bravo R, (1994) Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen. Oncogene 9: 3289-3297.
28. Xia Y, Pauza ME, Feng L, Lo D, (1997) RelB regulation of chemokine expression modulates local inflammation. Am J Pathol 151: 375-387.
29. Zanetti M, Castiglioni P, Schoenberger S, Gerloni M, (2003) The role of relB in regulating the adaptive immune response. Ann N Y Acad Sci 987: 249-257.
30. Terzidou V, Blanks AM, Kim SH, Thornton S, Bennett PR, (2011) Labor and inflammation increase the expression of oxytocin receptor in human amnion. Biol Reprod 84: 546-552.
31. Blanks AM, Vatish M, Allen MJ, Ladds G, de Wit NC, et al. (2003) Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. J Clin Endocrinol Metab 88: 3392-3400.
32. Chibbar R, Miller FD, Mitchell BF, (1993) Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition. J Clin Invest 91: 185-192.
33. Hinko A, Soloff MS, (1992) Characterization of oxytocin receptors in rabbit amnion involved in the production of prostaglandin E2. Endocrinology 130: 3547-3553.
34. Fuchs AR, Fuchs F, Husslein P, Soloff MS, Fernstrom MJ, (1982) Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science 215: 1396-1398.
35. Soloff MS, Hinko A, (1993) Oxytocin receptors and prostaglandin release in rabbit amnion. Ann N Y Acad Sci 689: 207-218.
36. Hsu CD, Meaddough E, Basherra H, Harirah H, Lu LC, (2000) Increased apoptosis in human amnion is associated with labor at term. Am J Reprod Immunol 43: 255-258.
37. Kumagai K, Otsuki Y, Ito Y, Shibata MA, Abe H, et al. (2001) Apoptosis in the normal human amnion at term, independent of Bcl-2 regulation and onset of labour. Mol Hum Reprod 7: 681-689.
38. Karin M, Lin A, (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3: 221-227.
39. Hsu H, Xiong J, Goeddel DV, (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495-504.
40. Meteoglu I, Erdogdu IH, Meydan N, Erkus M, Barutca S, (2008) NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues. J Exp Clin Cancer Res 27: 53.
41. Connolly JM, Rose DP, (1990) Production of epidermal growth factor and transforming growth factor-alpha by the androgen-responsive LNCaP human prostate cancer cell line. Prostate 16: 209-218.
42. Connolly JM, Rose DP, (1991) Autocrine regulation of DU145 human prostate cancer cell growth by epidermal growth factor-related polypeptides. Prostate 19: 173-180.
43. Ackerman WE, Rovin BH, Kniss DA, (2004) Epidermal growth factor and interleukin-1beta utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells. Biol Reprod 71: 2079-2086.
44. Bennett PR, Rose MP, Myatt L, Elder MG, (1987) Preterm labor: stimulation of arachidonic acid metabolism in human amnion cells by bacterial products. Am J Obstet Gynecol 156: 649-655.
45. Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, et al. (2000) Functional discovery via a compendium of expression profiles. Cell 102: 109-126.