Reduced decorin, fibromodulin, and transforming growth factor-β3 in deep dermis leads to hypertrophic scarring

Journal of Burn Care and Research

Volumn 33, Issue 2, 2012, Pages 218-227

  Honardoust, Dariush ^a   Varkey, Mathew ^a   Marcoux, Yvonne ^a   Shankowsky, Heather A ^a   Tredget, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DECORIN; FIBROMODULIN; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3;

ADULT; ARTICLE; DEEP WOUND SCAR; DERMIS; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; HYPERTROPHIC SCAR; IMMUNOFLUORESCENCE TEST; MALE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INJURY; SUPERFICIAL WOUND SCAR; WESTERN BLOTTING; WOUND HEALING;

ANALYSIS OF VARIANCE; BLOTTING, WESTERN; BURNS; CICATRIX, HYPERTROPHIC; DECORIN; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MALE; MICROSCOPY, CONFOCAL; OCCLUSIVE DRESSINGS; POLYMERASE CHAIN REACTION; PROTEOGLYCANS; THIGH; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84859217890     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e3182335980     Document Type: Article

References (37)

1. Wang J, Dodd C, Shankowsky HA, Scott PG, Tredget EE; Wound Healing Research Group. Deep dermal fibroblasts contribute to hypertrophic scarring. Lab Invest 2008;88: 1278-90.
2. Gallant CL, Olson ME, Hart DA. Molecular, histologic and gross phenotype of skin wound healing in red Duroc pigs reveals an abnormal healing phenotype of hypercontracted, hyperpigmented scarring. Wound Repair Regen 2004;12: 305-19. (Pubitemid 38880439)
3. Sappino AP, Masouyé I, Saurat JH, Gabbiani G. Smooth muscle differentiation in scleroderma fibroblastic cells. Am J Pathol 1990;137:585-91. (Pubitemid 20280988)
4. Wrana JL, Attisano L, Cárcamo J, et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 1992;71:1003-14.
5. Souchelnytskyi S, Rönnstrand L, Heldin CH, ten Dijke P. Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases. Methods Mol Biol 2001;124: 107-20.
6. Shah M, Foreman DM, Ferguson MW. Neutralization of TGF-beta 1and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995;108:985-1002.
7. Giri SN, Hyde DM, Braun RK, Gaarde W, Harper JR, Pierschbacher MD. Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis. Biochem Pharmacol 1997; 54:1205-16. (Pubitemid 27497247)
8. Nakao A, Fujii M, Matsumura R, et al. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999;104:5-11. (Pubitemid 29534339)
9. Wang Z, Gao Z, Shi Y, et al. Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts. J Plast Reconstr Aesthet Surg 2007;60:1193-9. (Pubitemid 47570828)
10. Hildebrand A, Romaris M, Rasmussen LM, et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 1994;302:527-34. (Pubitemid 24280108)
11. Soo C, Hu FY, Zhang X, et al. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol 2000;157:423-33. (Pubitemid 30626906)
12. Kolb M, Margetts PJ, Sime PJ, Gauldie J. Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol 2001;280:L1327-34.
13. Sorrell JM, Baber MA, Caplan AI. Site-matched papillary and reticular human dermal fibroblasts differ in their release of specific growth factors/cytokines and in their interaction with keratinocytes. J Cell Physiol 2004;200:134-45. (Pubitemid 38720629)
14. Hagood JS, Lasky JA, Nesbitt JE, Segarini P. Differential expression, surface binding, and response to connective tissue growth factor in lung fibroblast subpopulations. Chest 2001; 120(1 Suppl):64S- 6S.
15. Zhou Y, Hagood JS, Murphy-Ullrich JE. Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli. Am J Pathol 2004;165:659-69. (Pubitemid 38971395)
16. Hagood JS, Prabhakaran P, Kumbla P, et al. Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol 2005;167:365-79. (Pubitemid 43026094)
17. Dunkin CS, Pleat JM, Gillespie PH, Tyler MP, Roberts AH, McGrouther DA. Scarring occurs at a critical depth of skin injury: precise measurement in a graduated dermal scratch in human volunteers. Plast Reconstr Surg 2007;119:1722-32; discussion 1733-4.
18. Bucala R. Circulating fibrocytes: cellular basis for NSF. J Am Coll Radiol 2008;5:36-9.
19. Sakai N, Wada T, Matsushima K, et al. The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. J Hypertens 2008;26:780-90. (Pubitemid 351354927)
20. Yang L, Scott PG, Dodd C, et al. Identification of fibrocytes in postburn hypertrophic scar. Wound Repair Regen 2005; 13:398-404. (Pubitemid 41060421)
21. Wang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE. Improvement in postburn hypertrophic scar after treatment with IFN-alpha2b is associated with decreased fibrocytes. J Interferon Cytokine Res 2007;27:921-30. (Pubitemid 350223113)
22. Liang Z, Xie CY, Lin HB, Guo ZD, Yang WG. Pathomorphological observation of the hypertrophic scar induced by injury to conical structure in female red Duroc pig. Zhonghua Shao Shang Za Zhi 2006;22:29-32.
23. Oliveira GV, Hawkins HK, Chinkes D, et al. Hypertrophic versus non hypertrophic scars compared by immunohistochemistry and laser confocal microscopy: type I and III collagens. Int Wound J 2009;6:445-52.
24. Mohan RR, Gupta R, Mehan MK, Cowden JW, Sinha S. Decorin transfection suppresses profibrogenic genes and myofibroblast formation in human corneal fibroblasts. Exp Eye Res 2010;91:238-45.
25. Stoff A, Rivera AA, Mathis JM, et al. Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds. J Mol Med (Berl) 2007;85:481-96. (Pubitemid 46701657)
26. Alimohamad H, Habijanac T, Larjava H, Häkkinen L. Colocalization of the collagen-binding proteoglycans decorin, biglycan, fibromodulin and lumican with different cells in human gingiva. J Periodontal Res 2005;40:73-86. (Pubitemid 40186630)
27. Honardoust D, Eslami A, Larjava H, Häkkinen L. Localization of small leucine-rich proteoglycans and transforming growth factor-beta in human oral mucosal wound healing. Wound Repair Regen 2008;16:814-23.
28. Scott PG, Dodd CM, Tredget EE, Ghahary A, Rahemtulla F. Immunohistochemical localization of the proteoglycans decorin, biglycan and versican and transforming growth factor-beta in human post-burn hypertrophic and mature scars. Histopathology 1995;26:423-31.
29. Pohlers D, Brenmoehl J, Löffler I, et al. TGF-beta and fibrosis in different organs-molecular pathway imprints. Biochim Biophys Acta 2009;1792:746-56.
30. Bandyopadhyay B, Fan J, Guan S, et al. A "traffic control"role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol 2006;172: 1093-105.
31. Colwell AS, Yun R, Krummel TM, Longaker MT, Lorenz HP. Keratinocytes modulate fetal and postnatal fibroblast transforming growth factor-beta and Smad expression in coculture. Plast Reconstr Surg 2007;119:1440-5.
32. Goldberg SR, McKinstry RP, Sykes V, Lanning DA. Rapid closure of midgestational excisional wounds in a fetal mouse model is associated with altered transforming growth factorbeta isoform and receptor expression. J Pediatr Surg 2007; 42:966-71; discussion 971-3.
33. Cowin AJ, Holmes TM, Brosnan P, Ferguson MW. Expression of TGF-beta and its receptors in murine fetal and adult dermal wounds. Eur J Dermatol 2001;11:424-31. (Pubitemid 32801338)
34. Komuta Y, Teng X, Yanagisawa H, Sango K, Kawamura K, Kawano H. Expression of transforming growth factor-beta receptors in meningeal fibroblasts of the injured mouse brain. Cell Mol Neurobiol 2010;30:101-11.
35. Chu Y, Guo F, Li Y, Li X, Zhou T, Guo Y. A novel truncated TGF-beta receptor II downregulates collagen synthesis and TGF-beta I secretion of keloid fibroblasts. Connect Tissue Res 2008;49:92-8.
36. Keeley EC, Mehrad B, Strieter RM. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders. Thromb Haemost 2009;101:613-8.
37. Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 2004;36:598-606. (Pubitemid 38316817)