The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway

Cytokine

Volumn 58, Issue 2, 2012, Pages 238-244

  Otani, Masataka ^a   Kogo, Mikihiko ^a   Furukawa, Souhei ^a   Wakisaka, Satoshi ^a   Maeda, Takashi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Adipokine; CAMP; CTRP3; PKA; Testosterone

Indexed keywords

ADIPOCYTOKINE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); COLLAGENOUS REPEAT CONTAINING SEQUENCE OF THE 26 KDA PROTEIN; COMPLEMENT COMPONENT C1Q; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; LEYDIG CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TESTIS; TESTOSTERONE SYNTHESIS; UPREGULATION;

ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA PRIMERS; IMMUNOHISTOCHEMISTRY; LEYDIG CELLS; MALE; MICE; POLYMERASE CHAIN REACTION; PROTEINS; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 84859217094     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.01.018     Document Type: Article

References (44)

1. Wong G.W., Krawczyk S.A., Kitidis-Mitrokostas C., Revett T., Gimeno R., Lodish H.F. Molecular, biochemical and functional characterization of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J 2008, 416:161-177.
2. Kishore U., Gaboriaud C., Waters P., Shrive A.K., Greenhough T.J., Reid K.B.M., et al. C1q and tumor necrosis factor superfamily: modularity and versatility. Trends Immunol 2004, 25:551-561.
3. Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F. A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci USA 2004, 101:10302-10307.
4. Lasser G., Guchhait P., Ellsworth J.L., Sheppard P., Lewis K., Bishop P., et al. C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood 2006, 107:423-430.
5. Jeon J.H., Kim K.Y., Kim J.H., Baek A., Cho H., Lee Y.H., et al. A novel adipokine CTRP1 stimulates aldosterone production. FASEB J 2008, 22:1502-1511.
6. Mandal M.N., Vasireddy V., Reddy G.B., Wang X., Moroi S.E., Pattnaik B.R., et al. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 2006, 47:5505-5513.
7. Lee W., Kim M.J., Park E.J., Choi Y.J., Park S.Y. C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase. FEBS Lett 2010, 584:968-972.
8. Wong G.W., Krawczyk S.A., Kitidis-Mitrokostas C., Ge G., Spooner E., Hug C., et al. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterodimers with adiponectin. FASEB J 2009, 23:241-258.
9. Maeda T., Abe M., Kurisu K., Jikko A., Furukawa S. Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development. J Biol Chem 2001, 276:3628-3634.
10. Maeda T., Jikko A., Abe M., Yokohama-Tamaki T., Akiyama H., Furukawa S., et al. Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes. J Cell Physiol 2006, 206:537-544.
11. Akiyama H., Furukawa S., Wakisaka S., Maeda T. Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways. FEBS J 2006, 273:2257-2263.
12. Yokohama-Tamaki T., Maeda T., Tanaka T.S., Shibata S. Functional analysis of CTRP3/cartducin in Meckel's cartilage and developing condylar cartilage in the fetal mouse mandible. J Anat 2011, 218:517-533.
13. Akiyama H., Furukawa S., Wakisaka S., Maeda T. CTRP3/cartducin promotes proliferation and migration of endothelial cells. Mol Cell Biochem 2007, 304:243-248.
14. Akiyama H., Furukawa S., Wakisaka S., Maeda T. Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation. Oncol Rep 2009, 21:1477-1481.
15. Maeda T., Wakisaka S. CTRP3/cartducin is induced by transforming growth factor-beta 1 and promotes vascular smooth muscle cell proliferation. Cell Biol Int 2010, 34:261-266.
16. Weigart T., Neumeier M., Schaffler A., Fleck M., Scholmerich J., Schutz C., et al. The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells. FEBS Lett 2005, 579:5565-5570.
17. Kopp A., Bala M., Buechler C., Falk W., Gross P., Neumeier M., et al. C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue. Endocrinology 2010, 151:5267-5278.
18. Peterson J.M., Wei Z., Wong G.W. C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem 2010, 285:39691-39701.
19. Haider S.G. Cell biology of Leydig cells in the testis. Int Rev Cytol 2004, 233:181-241.
20. Bellve A.R., Zheng W. Growth factors as autocrine and paracrine modulators of male gonadal functions. J Reprod Fertil 1989, 85:771-793.
21. Lejeune H., Chuzel F., Thomas T., Avallet O., Habert R., Durand P., et al. Paracrine regulation of Leydig cells. Ann Endocrinol 1996, 57:55-63.
22. Hwang G.S., Wang S.W., Tseng W.M., Yu C.H., Wang P.S. Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells. Am J Physiol Endocrinol Metab 2007, 292:1763-1769.
23. Mather J.P. Establishment and characterization of two distinct mouse testicular epithelial cell line. Biol Reprod 1980, 23:243-252.
24. Guyot R., Odet F., Leduque P., Forest M.G., Le Magueresse-Battistoni B. Diethylstilbestrol inhibits the expression of the steroidogenic acute regulatory protein in mouse fetal testis. Mol Cell Endocrinol 2004, 220:67-75.
25. Christensen A.K., Peacock K.C. Increase in Leydig cell number in testes of adult rats treated chronically with an excess of human chorionic gonadotrophin. Biol Reprod 1980, 22:383-391.
26. Stocco D.M. Recent advances in the role of StAR. Rev Reprod 1998, 3:82-85.
27. Payne A.H., Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 2004, 25:947-970.
28. Stocco D.M. StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol 2001, 63:193-213.
29. Mellon S.H., Vaisse C. CAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Proc Natl Acad Sci USA 1989, 86:7775-7779.
30. Inoue H., Watanabe N., Higashi Y., Fujii-Kuriyama Y. Structures of regulatory regions in the human cytochrome P-450scc (desmolase) gene. Eur J Biochem 1991, 195:563-569.
31. Manna P.R., Eubank D.W., Lalli E., Sassone-Corsi P., Stocco D.M. Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1. J Mol Endocrinol 2003, 30:381-397.
32. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
33. Moger W. Evidence for compartmentalization of adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinases in rat Leydig cells using site-selective cAMP analogs. Endocrinology 1991, 128:1414-1418.
34. Zhu X., Birnbaumer L. G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha (16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein. Proc Natl Acad Sci USA 1996, 93:2827-2831.
35. Stocco D.M., Wang X.J., Jo Y., Manna P.R. Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol Endocrinol 2005, 19:2647-2659.
36. Manna P.R., Chandrala S.P., Jo Y., Stocco D.M. CAMP-independent signaling regulates steroidogenesis in mouse Leydig cells in the absence of StAR phosphorylation. J Mol Endocrinol 2006, 37:81-95.
37. Goldsmith Z.G., Dhanasekaran D.N. G protein regulation of MAPK networks. Oncogene 2007, 26:3122-3142.
38. Mei F.C., Qiao J., Tsygankova O.M., Meinkoth J.L., Quilliam L.A., Cheng X. Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem 2002, 277:11497-11504.
39. Brennesvik E.O., Ktori C., Ruzzin J., Jebens E., Shepherd P.R., Jensen J. Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline. Cell Signal 2005, 17:1551-1559.
40. Manolagas S.C., Kousteni S., Jilka R.L. Sex steroids and bone. Recent Prog Horm Res 2002, 57:385-409.
41. Maor G., Segev Y., Phillip M. Testosterone stimulates insulin-like growth factor-I and insulin-like growth factor-I receptor gene expression in the mandibular condyle - a model of endochondral ossification. Endocrinology 1999, 140:1901-1910.
42. Vanderschueren D., Vandenput L., Boonen S., Lindberg M.K., Bouillon R., Ohlsson C. Androgens and bone. Endocr Rev 2004, 25:389-425.
43. Englert C., Blunk T., Fierlbeck J., Kaiser J., Stosiek W., Angele P., et al. Steroid hormones strongly support bovine articular cartilage integration in the absence of interleukin-1beta. Arthritis Rheum 2006, 54:3890-3897.
44. Koelling S., Miosge N. Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis. Arthritis Rheum 2010, 62:1077-1087.