Static micromixer-coaxial electrospray synthesis of theranostic lipoplexes

ACS Nano

Volumn 6, Issue 3, 2012, Pages 2245-2252

  Wu, Yun ^a   Li, Lei ^a   Mao, Yicheng ^a,b   Lee, Ly James ^a,b  

^a The Ohio State University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

coaxial electrospray; F rster resonance energy transfer; lipoplexes; oligonucleotides; quantum dots; static micromixer; theranostic nanomedicine

Indexed keywords

ELECTROSPRAYS; LIPOPLEXES; NANOMEDICINES; QUANTUM DOT; STATIC MICRO-MIXER;

CELL CULTURE; CONFOCAL MICROSCOPY; ENCAPSULATION; ENERGY TRANSFER; FLOW CYTOMETRY; GENE EXPRESSION; MEDICAL NANOTECHNOLOGY; MIXING; OLIGONUCLEOTIDES; SEMICONDUCTOR QUANTUM DOTS;

MIXERS (MACHINERY);

ANTISENSE OLIGODEOXYNUCLEOTIDE; CARBOCYANINE; CYANINE DYE 5; DIAGNOSTIC AGENT; NUCLEOTIDE; OBLIMERSEN; PROTEIN BCL 2; QUANTUM DOT;

ARTICLE; CHEMISTRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; INTRACELLULAR SPACE; METABOLISM; METHODOLOGY; NANOMEDICINE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

BIOLOGICAL TRANSPORT; CARBOCYANINES; CELL LINE, TUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; INTRACELLULAR SPACE; NANOMEDICINE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS C-BCL-2; QUANTUM DOTS; THIONUCLEOTIDES;

EID: 84859141584     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn204300s     Document Type: Article

References (28)

1. Jahn, A.; Vreeland, W. N.; Gaitan, M.; Locascio, L. E. Controlled Vesicle Self-Assembly in Microfluidic Channels with Hydrodynamic Focusing J. Am. Chem. Soc. 2004, 126, 2674-2675
2. Jahn, A.; Vreeland, W. N.; DeVoe, D. L.; Locascio, L. E.; Gaitan, M. Microfluidic Directed Formation of Liposomes of Controlled Size Langmuir 2007, 23, 6289-6293
3. Jahn, A.; Reiner, J. E.; Vreeland, W. N.; DeVoe, D. L.; Locascio, L. E.; Gaitan, M. Preparation of Nanoparticles by Continuous-Flow Microfluidics J. Nanopart. Res. 2008, 10, 925-934
4. Jahn, A.; Stavis, S. M.; Hong, J. S.; Vreeland, W. N.; DeVoe, D. L.; Gaitan, M. Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles ACS Nano 2010, 4, 2077-2087
5. Koh, C. G.; Zhang, X.; Liu, S.; Golan, S.; Yu, B.; Yang, X.; Guan, J.; Jin, Y.; Talmon, Y.; Muthusamy, N. et al. Delivery of Antisense Oligodeoxyribonucleotide Lipopolyplex Nanoparticles Assembled by Microfluidic Hydrodynamic Focusing J. Controlled Release 2010, 141, 62-69
6. Yu, B.; Zhu, J.; Xue, W.; Wu, Y.; Huang, X.; Lee, L. J.; Lee, R. J. Microfluidic Assembly of Lipid-Based Oligonucleotide Nanoparticles Anticancer Res. 2011, 31, 771-776
7. Valencia, P. M.; Basto, P. A.; Zhang, L.; Rhee, M.; Langer, R.; Farokhzad, O. C.; Karnik, R. Single-Step Assembly of Homogenous Lipid-Polymeric and Lipid-Quantum Dot Nanoparticles Enabled by Microfluidic Rapid Mixing ACS Nano 2010, 4, 1671-1679
8. Fenn, J. B.; Mann, M.; Meng, C. K.; Wong, S. F.; Whitehouse, C. M. Electrospray Ionization for Mass Spectrometry of Large Biomolecules Science 1989, 246, 64-71
9. Salata, V. Tools of Nanotechnology: Electrospray Curr. Nanosci. 2005, 1, 25-33
10. Yurteri, C. U.; Hartman, R. P. A; Marijnissen, J. C. M. Producing Pharmaceutical Particles via Electrospraying with an Emphasis on Nano and Nano Structured Particles-A Review KONA Powder Part. J. 2010, 28, 91-115
11. Jaworek, A.; Sobczyk, A. T. Electrospraying Route to Nanotechnology: An Overview J. Electrostat. 2008, 66, 197-219
12. Wu, Y.; Yu, B.; Jackson, A.; Zha, W.; Lee, L. J.; Wyslouzil, B. E. Coaxial Electrohydrodynamic Spraying: A Novel One-Step Technique To Prepare Oligodeoxynucleotide Encapsulated Lipoplex Nanoparticles Mol. Pharmaceutics 2009, 6, 1371-1379
13. Wu, Y.; Fei, Z.; Lee, L. J.; Wyslouzil, B. E. Electrohydrodynamic Spraying of DNA/Polyethylenimine Polyplexes for Nonviral Gene Delivery Biotechnol. Bioeng. 2009, 105, 834-841
14. Chen, D. R.; Wendt, C. H.; Pui, D. Y. H. A Novel Approach for Introducing Bio-materials into Cells J. Nanopart. Res. 2000, 2, 133-139
15. Jayasinghe, S, N.; Qureshi, A, N.; Eagles, P. A. M. Electrohydrodynamic Jet Processing: An Advanced Electric-Field-Driven Jetting Phenomenon for Processing Living Cells Small 2006, 2, 216-219
16. Pareta, R.; Brindley, A.; Edirisinghe, M. J.; Jayasinghe, S. N.; Lukinska, Z. B. Electrohydrodynamic Atomization of Protein (Bovine Serum Albumin) J. Mater. Sci: Mater. Med. 2005, 16, 919-925
17. Xie, J.; Wang, C. Encapsulation of Proteins in Biodegradable Polymeric Microparticles Using Electrospray in the Taylor Cone-jet Mode Biotechnol. Bioeng. 2007, 97, 1278-1290
18. Wu, Y.; Chalmers, J. J.; Wyslouzil, B. E. The Use of Electrohydrodynamic Spraying To Disperse Hydrophobic Compounds in Aqueous Media Aerosol Sci. Technol. 2009, 43, 902-910
19. Li, L.; Lee, L. J.; Castro, J. M.; Yi, A. Y. Improving Mixing Efficiency of a Polymer Micromixer by Use of a Plastic Shim Divider J. Micromech. Microeng. 2010, 20, 035012
20. Li, L.; Yang, C.; Shi, H.; Liao, W. C.; Huang, H.; Lee, L. J.; Castro, J. M.; Yi, A. Y. Design and Fabrication of an Affordable Polymer Micromixer for Medical and Biomedical Applications Polym. Eng. Sci. 2010, 50, 1594-1604
21. Farokhzad, O. C.; Langer, R. Nanomedicine: Developing Smarter Therapeutic and Diagnostic Modalities Adv. Drug Delivery Rev. 2006, 58, 1456-1459
22. Hillaireau, H.; Couvreur, P. Nanocarriers Entry into the Cell: Relevance to Drug Delivery Cell. Mol. Life Sci. 2009, 66, 2873-2896
23. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 2, 751-760
24. Medintz, I. L.; Mattoussi, H. Quantum Dot-Based Resonance Energy Transfer and Its Growing Application in Biology Phys. Chem. Chem. Phys. 2009, 11, 17-45
25. Michalet, X.; Pinaud, F. F.; Bentolila, L. A.; Tsay, J. M.; Doose, S.; Li, J. J.; Sundaresan, G.; Wu, A. M.; Gambhir, S. S.; Weiss, S. Quantum Dots for Live Cells, In Vivo Imaging, and Diagnostics Science 2005, 307, 538-544
26. Delehanty, J. B.; Bradburne, C. E.; Boeneman, K.; Susumu, K; Farrell, D.; Mei, B, C.; Blanco-Canosa, J. B.; Dawson, G.; Dawson, P. E.; Mattoussi, H. et al. Delivering Quantum Dot-Peptide Bioconjugates to the Cellular Cytosol: Escaping from the Endolysosomal System Integr. Biol. 2010, 2, 265-277
27. Janib, S. M.; Moses, A. S.; MacKay, J. A. Imaging and Drug Delivery Using Theranostic Nanoparticles Adv. Drug Delivery Rev. 2010, 62, 1052-1063
28. Park, K.; Lee, S.; Kang, E.; Kim, K.; Choi, K.; Kwon, I. C. New Generation of Multifunctional Nanoparticles for Cancer Imaging and therapy Adv. Funct. Mater. 2009, 19, 1553-1566