Blindness in dogs with pituitary dependent hyperadrenocorticism: Relationship with glucose, cortisol and triglyceride concentration and with ophthalmic blood flow

Research in Veterinary Science

Volumn 92, Issue 3, 2012, Pages 387-392

  Cabrera Blatter, M F ^a   del Prado, A ^a   Gallelli, M F ^a   D'Anna, E ^b   Ivanic, J ^a   Esarte, M ^c   Miceli, D D ^a   Gomez N V ^a   Castillo, V A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b U Diagnóstico por Imágenes   (Argentina)

^c FCV UBA   (Argentina)

Author keywords

Blindness; Cortisol; Glucose; Hypercortisolism; Pituitary dependent hyperadrenocorticism

Indexed keywords

GLUCOSE; HYDROCORTISONE; TRIACYLGLYCEROL;

A WAVE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B WAVE; BLINDNESS; CONTROLLED STUDY; DOG DISEASE; ECHOOCULOGRAPHY; ELECTRORETINOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HYDROCORTISONE BLOOD LEVEL; HYPERADRENOCORTICISM; MALE; NONHUMAN; OPTIC CHIASM; PITUITARY DEPENDENT HYPERADRENOCORTICISM; RETINA BLOOD FLOW; TRIACYLGLYCEROL BLOOD LEVEL; VISUAL IMPAIRMENT;

ADRENOCORTICAL HYPERFUNCTION; ANIMALS; BLINDNESS; BLOOD GLUCOSE; DOG DISEASES; DOGS; FEMALE; HYDROCORTISONE; MALE; PITUITARY GLAND; RETINAL VESSELS; TRIGLYCERIDES;

CANIS FAMILIARIS;

EID: 84859110052     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2011.04.017     Document Type: Article

References (46)

1. Andrews R.C., Walker B.R. Glucocorticoids and insulin resistance: old hormones, new targets. Clinical Science (London) 1999, 96:513-523.
2. Arnaldi G., Angeli A., Atkinson A.B., Bertagna X., Cavagnini F., Chrousos G.P., Fava G.A., Findling J.W., Gaillard R.C., Grossman A.B., Kola B., Lacroix A., Mancini T., Mantero F., Newell-Price J., Nieman L.K., Sonino N., Vance M.L., Giustina A., Boscaro M. Diagnosis and complications of Cushing's syndrome: a consensus statement. Journal Clinics Endocrinology Metabolism 2003, 88:5593-5602.
3. Beale E.G., Robert E., Hammer R.E., Antoine B., Forest C. Disregulated glyceroneogenesis: PCK1 as a candidate diabetes and obesity gene. Trends Endocrinology Metabolism 2004, 15:129-135.
4. Bosje J., Rijnberk A., Mol J., Voorhout G., Kooistra H. Plasma concentrations of ACTH precursors correlate with pituitary size and resistance to dexamethasone in dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology 2002, 22:201-210.
5. Caballero A.E. Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. Archives Medical Research 2005, 36:241-249.
6. Cassuto H., Kochan K., Chakravarty K., Cohen H., Blum B., Olswang Y., Hakimi P., Xu C., Massillon D., Hanson R.W., Reshef L. Glucocorticoids regulate transcription of the gen for phophoenolpyruvate carboxykinase (GTP) in the liver via an extended glucocorticoid regulatory unit. Journal of Biological Chemistry 2005, 280:33873-33884.
7. Castillo V.A., Gómez N.V., Lalia J.C., Cabrera Blatter M.F., García J.D. Cushing's disease in dogs: Cabergoline treatment. Research in Veterinary Science 2008, 85:26-34.
8. Castillo V.A., Gallelli M.F. Corticotroph adenoma in the dog: pathogenesis and new therapeutic possibilities. Research Veterinary Science 2010, 88:26-32.
9. Dahia P.M., Grossman A. The molecular pathogenesis of corticotroph tumors. Endocrinology Review 1999, 20:136-155.
10. Dodson P.M., Galton D.J., Hamilton A.M., Blach R.K. Retinal vein occlusion and the prevalence of lipoprotein abnormalities. British Journal of Ophthalmology 1982, 66:161-164.
11. Ekesten B. Ophthalmic examination and diagnostics. Veterinary Ophthalmology 2007, 510-535. Blackwell Publishing, Iowa USA. fourth ed. K.N. Gelatt (Ed.).
12. Galac S., Kooistra H., Teske E., Rijnberk A. Urinary corticoid/creatinina ratios in the differentiation between pituitary-dependent hyperadrenocorticism and hyperadrenocorticism due to adrenocortical tumour in the dog. Veterinary Quarterly 1997, 19:17-20.
13. Gallelli M.F., Cabrera Blatter M.F., Castillo V. A comparative study by age and gender of the pituitary adenoma and ACTH and a-MSH secretion in dogs with pituitary-dependent hyperadrenocorticism. Research in Veterinary Science 2010, 88:33-40.
14. Ginsberg H.N., Huang L.S. The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis. Journal Cardiovascular Risk 2000, 7:325-331.
15. Gittoes N.J.L. Pituitary radiotherapy: current controversies. Trends Endocrinology Metabolism 2005, 16:407-413.
16. Granger N., de Fornel P., Devauchelle P., Segond S., Delisle F., Rosenberg D. Plasma pro-opiomelanocortin, pro-adrenocorticotropin hormone, and pituitary adenoma size in dogs with Cushing's disease. Journal of Veterinary Internal Medicine 2005, 19:23-28.
17. Grunwald J.E., DuPont J., Riva C.E. Retinal haemodynamics in patients with early diabetes mellitus. British Journal Ophthalmology 1996, 80:327-331.
18. Hackman A., Yasunori A., Insull W., Pownall H., Smith L., Dunn K., Gotto A., Dphil M.D., Ballantyne C.M. Levels of soluble cell adhesion molecules in patients with dyslipidemia. Circulation 1996, 93:1334-1338.
19. Hess R.S., Kass P.H., Van Winkle T.J. Association between diabetes mellitus, hypothyroidism or hyperadrenocorticism, and atherosclerosis in dogs. Journal of Veterinary Internal Medicine 2003, 17:489-494.
20. Hollwich F., Dieckhues B. Circadian rhythm in the blind. Biological Rhythm 1971, 2:291-301.
21. Ikram M.K., Jong F.J., Vingerling J.R., Witterman J.C., Hofman A., Breteler M., Jong P. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam study. Investigative Ophthalmology and Visual Science 2004, 45:2129-2134.
22. Irving R.J., Walker B.R., Noon J.P., Watt G.C., Webb D.J., Shore A.C. Microvascular correlates of blood pressure, plasma glucose and insulin resistance in health. Cardiovascular Research 2002, 53:271-276.
23. Jericó M.M., De Camargo Chiquito F., Kajihara K., Bastistela Moreira M.A., Gonzales R., Lorenzini Aranha Machado F., Sutti Nunes V., Catanozi S., Nakandakare E.R. Chromatographic analysis of lipid fractions in healthy dogs and dogs with obesity or hyperadrenocorticism. Journal Veterinary Diagnostic Investigation 2009, 21:203-207.
24. Luchi T., Akaike M., Mitsui T., Ohshima Y., Shintani Y., Azuma H., Matsumoto T. Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction. Circulation Research 2003, 92:81-87.
25. Melmed S. Mechanisms for pituitary tumorigenesis: the plastic pituitary. Journal of Clinical Investigation 2003, 112:1603-1618.
26. Mitchell B.M., Webb R.C. Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension. Biological Research for Nursing 2002, 4:16-21.
27. Moore R.Y., Eichler V.B. Loss of circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Research 1972, 42:201-206.
28. Nakayama K., Ishida N., Shirane M., Inomata A., Inoue T., Shishido N., Horii I., Loh D., Nakayama K.-i. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996, 85:707-720.
29. Narfström K., Ekesten B., Rosolen S.G., Spiess B.M., Percicot C.L., Ofri R. Guidelines for clinical electroretinography in the dog. Documenta ophthalmologica. Advances in Ophthalmology 2002, 105:83-92.
30. Nguyen T., Wong T.Y. Retinal vascular manifestations of metabolic disorders. Trends in Endocrinology and Metabolism 2006, 17:262-268.
31. Oren S., Grossman E., Frohlich E. Arterial and venous compliance in obese and nonobese subjects. American Journal Cardiology 1996, 77:665-667.
32. Orth D.N., Besser G.M., King P.H., Nicholson W.E. Free-running circadian plasma cortisol rhythm in a blind human subject. Clinical Endocrinology 1978, 10:603-617.
33. Rijnberk A., Mol J.A., Rothuizen J., Bevers M.M., Middleton D.J. Circulating pro-opiomelanocortin-derived peptides in dogs with pituitary-dependent hyperadrenocorticism. Frontiers of Hormone Research 1987, 17:48-60.
34. Ring C.P., Pearson T.C., Sanders T.M.D., Wetherley-Mein G. Viscosity and retinal vein thrombosis. British Journal of Ophthalmology 1976, 60:397-410.
35. Rodríguez Piñeiro M.I., Benchekroun G., De Fornel-Thibaud P., Maurey-Guenec C., Garnier F., Rosenberg D. Accuracy of an adrenocorticotropic hormone (ACTH) immunoluminometric assay for differentiating ACTH-dependent from ACTH-independent hyperadrenocorticism in dogs. Journal of Veterinary Internal Medicine 2009, 23:850-855.
36. Ross E.J., Linch D.C. Cushing's syndrome-killing disease: discriminatory values of signs and symptoms aiding early diagnosis. Lancet 1982, 2:646-649.
37. Sack R.L., Lewy A.J., Blood M.L., Keith L.D., Nakagawa H. Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. Journal of Clinical Endocrinology and Metabolism 1992, 75:127-134.
38. Sage D., Maurel D., Bosler O. Involvement of the suprachiasmatic nucleus in diurnal ACTH and corticosterone responsiveness to stress. American Journal Physiology Endocrinology and Metabolism 2001, 280:E260-E269.
39. Smalley D.M., Lin J., Curtis M.L., Kobari Y., Stemerman M.B., Pritchard K.A. Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule - arteriosclerosis. Thrombosis and Vascular Biology 1996, 16:585-590.
40. Teshima T., Hara Y., Takekoshi S., Teramoto A., Osamura R.Y., Tagawa M. Expression of genes related to corticotropin production and glucocorticoid feedback in corticotroph adenomas of dogs with Cushing's disease. Domestic Animal Endocrinology 2009, 36:3-12.
41. Vegiopoulos A., Herzig S. Glucocorticoids, metabolism and metabolic diseases. Molecular and Cellular Endocrinology 2007, 275:43-61.
42. Watts A.G., Tanimura S., Sanchez-Watts G. Corticotropin-realising hormone and arginine vasopressin gene transcription in the hypothalamic paraventricular nucleus of unstressed rats: daily rhythms and their interactions with corticosterone. Endocrinology 2004, 145:529-540.
43. Wong T.Y., Duncan B.B., Golden S., Klein R., Couper D., Klein B., Hubbard L., Sharrett A., Schmidt M. Associations between the metabolic syndrome and retinal microvascular signs: the atherosclerosis risk in communities study. Investigative Ophthalmology and Visual Science 2004, 45:2949-2954.
44. Xenoulis P.G., Steiner J.M. Lipid metabolism and hyperlipidemia in dogs. The Veterinary Journal 2010, 183:12-21.
45. Yang S., Zhang L. Glucocorticoids and vascular reactivity. Current Vascular Pharmacology 2004, 2:1-12.
46. Zhang L., Krzentowski G., Albert A., Lefebvre P.J. Risk of developing retinopathy in diabetes control and complications trial type 1 diabetic patients with good or poor metabolic control. Diabetes Care 2001, 24:1275-1279.