Expression of genes related to corticotropin production and glucocorticoid feedback in corticotroph adenomas of dogs with Cushing's disease

Domestic Animal Endocrinology

Volumn 36, Issue 1, 2009, Pages 3-12

  Teshima, Takahiro ^a   Hara, Yasushi ^a   Takekoshi, Susumu ^b   Teramoto, Akira ^c   Osamura, Robert Y ^b   Tagawa, Masahiro ^a  

^a Division of Veterinary Surgery   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Corticotroph adenoma; Cushing's disease; Dog; Negative feedback; Pituitary

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; PROOPIOMELANOCORTIN;

ACTH SECRETING ADENOMA; ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CUSHING DISEASE; DOG; DOG DISEASE; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION; GENETICS; HYPOPHYSIS TUMOR; MALE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ACTH-SECRETING PITUITARY ADENOMA; ADRENOCORTICOTROPIC HORMONE; ANIMALS; DOG DISEASES; DOGS; FEEDBACK, BIOCHEMICAL; FEMALE; GENE EXPRESSION; GLUCOCORTICOIDS; MALE; PITUITARY ACTH HYPERSECRETION; PITUITARY NEOPLASMS; PRO-OPIOMELANOCORTIN; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

CANIS FAMILIARIS;

EID: 56649103702     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2008.08.002     Document Type: Article

References (67)

1. Asa S.L., and Ezzat S. The pathogenesis of pituitary tumours. Nat Rev Cancer 2 (2002) 836-849
2. Fracassi F., Gandini G., Diana A., Preziosi R., Ingh T.S., Famigli-Bergamini P., et al. Acromegaly due to a somatroph adenoma in a dog. Domest Anim Endocrinol 32 (2007) 43-54
3. Feldman E.C., and Nelson R.W. Canine Hyperadrenocorticism (Cushing's syndrome). In: Feldman E.C., and Nelson R.W. (Eds). Canine and feline endocrinology and reproduction (2004), WB Saunders Co., Philadelphia 252-357
4. Peterson M.E., Krieger D.T., Drucker W.D., and Halmi N.S. Immunocytochemical study of the hypophysis in 25 dogs with pituitary-dependent hyperadrenocorticism. Acta Endocrinol (Copenh) 101 (1982) 15-24
5. Antoni F.A. Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr Rev 7 (1986) 351-378
6. Keller-Wood M.E., and Dallman M.F. Corticosteroid inhibition of ACTH secretion. Endocr Rev 5 (1984) 1-24
7. Trainer P.J., and Grossman A. The diagnosis and differential diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf) 34 (1991) 317-330
8. Peterson M.E. Hyperadrenocorticism. Vet Clin North Am Small Anim Pract 14 (1984) 731-749
9. Feldman E.C. Evaluation of a combined dexamethasone suppression/ACTH stimulation test in dogs with hyperadrenocorticism. J Am Vet Med Assoc 187 (1985) 49-53
10. Feldman E.C. Evaluation of a six-hour combined dexamethasone suppression/ACTH stimulation test in dogs with hyperadrenocorticism. J Am Vet Med Assoc 189 (1986) 1562-1566
11. Feldman E.C., Nelson R.W., and Feldman M.S. Use of low- and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs. J Am Vet Med Assoc 209 (1996) 772-775
12. Kooistra H.S., Voorhout G., Mol J.A., and Rijnberk A. Correlation between impairment of glucocorticoid feedback and the size of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism. J Endocrinol 152 (1997) 387-394
13. Bosje J.T., Rijnberk A., Mol J.A., Voorhout G., and Kooistra H.S. Plasma concentrations of ACTH precursors correlate with pituitary size and resistance to dexamethasone in dogs with pituitary-dependent hyperadrenocorticism. Domest Anim Endocrinol 22 (2002) 201-210
14. Granger N., de Fornel P., Devauchelle P., Segond S., Delisle F., and Rosenberg D. Plasma pro-opiomelanocortin, pro-adrenocorticotropin hormone, and pituitary adenoma size in dogs with Cushing's disease. J Vet Intern Med 19 (2005) 23-28
15. Asa S.L., and Ezzat S. The cytogenesis and pathogenesis of pituitary adenomas. Endocr Rev 19 (1998) 798-827
16. Herman V., Fagin J., Gonsky R., Kovacs K., and Melmed S. Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 71 (1990) 1427-1433
17. Dahia P.L., and Grossman A.B. The molecular pathogenesis of corticotroph tumors. Endocr Rev 20 (1999) 136-155
18. Suhardja A.S., Kovacs K.T., and Rutka J.T. Molecular pathogenesis of pituitary adenomas: a review. Acta Neurochir (Wien) 141 (1999) 729-736
19. Farrell W.E., and Clayton R.N. Molecular pathogenesis of pituitary tumors. Front Neuroendocrinol 21 (2000) 174-198
20. van Wijk P.A., Rijnberk A., Croughs R.J., Meij B.P., and Mol J.A. Effects of corticotrophin-releasing hormone, vasopressin and insulin-like growth factor-I on proliferation of and adrenocorticotrophic hormone secretion by canine corticotrophic adenoma cells in vitro. Eur J Endocrinol 138 (1998) 309-315
21. van Wijk P.A., Rijnberk A., Croughs R.J., Meij B.P., van Leeuwen I.S., Sprang E.P., et al. Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism. J Endocrinol Invest 20 (1997) 1-7
22. Hanson J.M., Mol J.A., Leegwater P.A., Bilodeau S., Drouin J., and Meij B.P. Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas. Domest Anim Endocrinol 34 (2008) 217-222
23. Meij B.P., Voorhout G., van den Ingh T.S., Hazewinkel H.A., Teske E., and Rijnberk A. Results of transsphenoidal hypophysectomy in 52 dogs with pituitary-dependent hyperadrenocorticism. Vet Surg 27 (1998) 246-261
24. Meij B.P., Voorhout G., Van den Ingh T.S., Hazewinkel H.A., and Van't Verlaat J.W. Transsphenoidal hypophysectomy in beagle dogs: evaluation of a microsurgical technique. Vet Surg 26 (1997) 295-309
25. Taoda T., Hara Y., Takekoshi S., Itoh J., Teramoto A., Osamura R.Y., et al. Effect of mitotane on pituitary corticotrophs in clinically normal dogs. Am J Vet Res 67 (2006) 1385-1394
26. Espina V., Wulfkuhle J.D., Calvert V.S., VanMeter A., Zhou W., Coukos G., et al. Laser-capture microdissection. Nat Protoc 1 (2006) 586-603
27. Sieber-Ruckstuhl N.S., Meli M.L., Boretti F.S., Gönczi E., Lutz H., and Reusch C.E. Quantitative real-time PCR for the measurement of 11beta-HSD1 and 11beta-HSD2 mRNA levels in tissues of healthy dogs. Horm Metab Res 39 (2007) 548-554
28. Brinkhof B., Spee B., Rothuizen J., and Penning L.C. Development and evaluation of canine reference genes for accurate quantification of gene expression. Anal Biochem 356 (2006) 36-43
29. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 18 (2002) 3 RESEARCH0034
30. Battaglia G., Webster E.L., and De Souza E.B. Characterization of corticotropin-releasing factor receptor-mediated adenylate cyclase activity in the rat central nervous system. Synapse 1 (1987) 572-581
31. Gagner J.P., and Drouin J. Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Mol Cell Endocrinol 40 (1985) 25-32
32. Clark A.J., Stewart M.F., Lavender P.M., Farrell W., Crosby S.R., Rees L.H., et al. Defective glucocorticoid regulation of proopiomelanocortin gene expression and peptide secretion in a small cell lung cancer cell line. J Clin Endocrinol Metab 70 (1990) 485-490
33. Suda T., Tozawa F., Yamada M., Ushiyama T., Tomori N., Sumitomo T., et al. In vitro study on proopiomelanocortin messenger RNA levels in cultured rat anterior pituitary cells. Life Sci 42 (1988) 1147-1152
34. Vig E., Barrett T.J., and Vedeckis W.V. Coordinate regulation of glucocorticoid receptor and c-jun mRNA levels: evidence for cross-talk between two signaling pathways' at the transcriptional level. Mol Endocrinol 8 (1994) 1336-1346
35. Gagner J.P., and Drouin J. Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing hormone, 3′,5′-cyclic adenosine monophosphate, and glucocorticoids. Mol Endocrinol 1 (1987) 677-682
36. Drouin J., Trifiro M.A., Plante R.K., Nemer M., Eriksson P., and Wrange O. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol Cell Biol 9 (1989) 5305-5314
37. Sapolsky R.M., Krey L.C., and McEwen B.S. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 7 (1986) 284-301
38. Dilman V.M., Revskoy S.Y., and Golubev A.G. Neuroendocrine-ontogenetic mechanism of aging: toward an integrated theory of aging. Int Rev Neurobiol 28 (1986) 89-156
39. Reul J.M., Rothuizen J., and de Kloet E.R. Age-related changes in the dog hypothalamic-pituitary-adrenocortical system: neuroendocrine activity and corticosteroid receptors. J Steroid Biochem Mol Biol 40 (1991) 63-69
40. Rothuizen J., Reul J.M., van Sluijs F.J., Mol J.A., Rijnberk A., and de Kloet E.R. Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs. Endocrinology 132 (1993) 161-168
41. Strasser A., Niedermüller H., Hofecker G., and Laber G. The effect of aging on laboratory values in dogs. Zentralbl Veterinarmed A 40 (1993) 720-730
42. Deuschle M., Gotthardt U., Schweiger U., Weber B., Körner A., Schmider J., et al. With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens. Life Sci 61 (1997) 2239-2246
43. Ferrari E., Cravello L., Muzzoni B., Casarotti D., Paltro M., Solerte S.B., et al. Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates. Eur J Endocrinol 144 (2001) 319-329
44. Ceccatelli S., Calzá L., and Giardino L. Age-related changes in the expression of corticotropin-releasing hormone receptor mRNA in the rat pituitary. Brain Res Mol Brain Res 37 (1996) 175-180
45. Tizabi Y., Aguilera G., and Gilad G.M. Age-related reduction in pituitary corticotropin-releasing hormone receptors in two rat strains. Neurobiol Aging 13 (1992) 227-230
46. Nelson J.F., Bender M., and Schachter B.S. Age-related changes in proopiomelanocortin messenger ribonucleic acid levels in hypothalamus and pituitary of female C57BL/6J mice. Endocrinology 123 (1988) 340-344
47. Heroux J.A., Grigoriadis D.E., and De Souza E.B. Age-related decreases in corticotropin-releasing factor (CRF) receptors in rat brain and anterior pituitary gland. Brain Res 542 (1991) 155-158
48. de Keyzer Y., René P., Beldjord C., Lenne F., and Bertagna X. Overexpression of vasopressin (V3) and corticotrophin-releasing hormone receptor genes in corticotroph tumours. Clin Endocrinol (Oxf) 49 (1998) 475-482
49. Tateno T., Izumiyama H., Doi M., Yoshimoto T., Shichiri M., Inoshita N., et al. Differential gene expression in ACTH -secreting and non-functioning pituitary tumors. Eur J Endocrinol 157 (2007) 717-724
50. De Kloet R., Wallach G., and McEwen B.S. Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 96 (1975) 598-609
51. Spencer R.L., Young E.A., Choo P.H., and McEwen B.S. Adrenal steroid type I and type II receptor binding: estimates of in vivo receptor number, occupancy, and activation with varying level of steroid. Brain Res 514 (1990) 37-48
52. Reul J.M., de Kloet E.R., van Sluijs F.J., Rijnberk A., and Rothuizen J. Binding characteristics of mineralocorticoid and glucocorticoid receptors in dog brain and pituitary. Endocrinology 127 (1990) 907-915
53. Krozowski Z., and Funder J.W. Mineralocorticoid receptors in rat anterior pituitary: toward a redefinition of "mineralocorticoid hormone". Endocrinology 109 (1981) 1221-1224
54. Moguilewsky M., and Raynaud J.P. Evidence for a specific mineralocorticoid receptor in rat pituitary and brain. J Steroid Biochem 12 (1980) 309-314
55. Peiffer A., Barden N., and Meaney M.J. Age-related changes in glucocorticoid receptor binding and mRNA levels in the rat brain and pituitary. Neurobiol Aging 12 (1991) 475-479
56. van Eekelen J.A., Rots N.Y., Sutanto W., and de Kloet E.R. The effect of aging on stress responsiveness and central corticosteroid receptors in the brown Norway rat. Neurobiol Aging 13 (1992) 159-170
57. Sheppard K.E., Roberts J.L., and Blum M. Differential regulation of type II corticosteroid receptor messenger ribonucleic acid expression in the rat anterior pituitary and hippocampus. Endocrinology 127 (1990) 431-439
58. Hügin-Flores M.E., Steimer T., Aubert M.L., and Schulz P. Mineralo- and glucocorticoid receptor mrnas are differently regulated by corticosterone in the rat hippocampus and anterior pituitary. Neuroendocrinology 79 (2004) 174-184
59. Stewart P.M., and Krozowski Z.S. 11 beta-Hydroxysteroid dehydrogenase. Vitam Horm 57 (1999) 249-324
60. Rabbitt E.H., Gittoes N.J., Stewart P.M., and Hewison M. 11beta-hydroxysteroid dehydrogenases, cell proliferation and malignancy. J Steroid Biochem Mol Biol 85 (2003) 415-421
61. Albiston A.L., Obeyesekere V.R., Smith R.E., and Krozowski Z.S. Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 105 (1994) 11-17
62. Tannin G.M., Agarwal A.K., Monder C., New M.I., and White P.C. The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. J Biol Chem 266 (1991) 16653-16658
63. Whorwood C.B., Sheppard M.C., and Stewart P.M. Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology 132 (1993) 2287-2292
64. Robson A.C., Leckie C.M., Seckl J.R., and Holmes M.C. 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. Brain Res Mol Brain Res 61 (1998) 1-10
65. Korbonits M., Bujalska I., Shimojo M., Nobes J., Jordan S., Grossman A.B., et al. Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors. J Clin Endocrinol Metab 86 (2001) 2728-2733
66. Rabbitt E.H., Ayuk J., Boelaert K., Sheppard M.C., Hewison M., Stewart P.M., et al. Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Oncogene 22 (2003) 1663-1667
67. Nigawara T., Iwasaki Y., Asai M., Yoshida M., Kambayashi M., Sashinami H., et al. Inhibition of 11beta-hydroxysteroid dehydrogenase eliminates impaired glucocorticoid suppression and induces apoptosis in corticotroph tumor cells. Endocrinology 147 (2006) 769-772