A double blind randomized cross over trial comparing rate of decortication and efficacy of intrapleural instillation of alteplase vs placebo in patients with empyemas and complicated parapneumonic effusions

Respiratory Medicine

Volumn 106, Issue 5, 2012, Pages 716-723

  Thommi, G ^a   Shehan, J C ^a   Robison, K L ^a   Christensen, M ^a   Backemeyer, L A ^a   McLeay, M T ^a  

^a CREIGHTON UNIVERSITY   (United States)

Author keywords

Alteplase; CPE (complicated parapneumonic effusion); Empyema; Tissue plaminogen activator (tPA)

Indexed keywords

ALTEPLASE; PLACEBO;

ADULT; AGED; ANEMIA; ARTICLE; BLEEDING; CLINICAL EVALUATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DECORTICATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INSTILLATION; DRUG SAFETY; DRUG TREATMENT FAILURE; FEMALE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; PLEURA EFFUSION; PLEURA EMPYEMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; THORAX PAIN; TUBE;

ADULT; AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EMPYEMA, PLEURAL; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; PLEURAL EFFUSION; PNEUMONIA; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84859106012     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2012.02.005     Document Type: Article

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