Do the urinary bladder and large bowel interact, in sickness or in health?: ICI-RS 2011

Neurourology and Urodynamics

Volumn 31, Issue 3, 2012, Pages 352-358

  Malykhina, Anna P ^a   Wyndaele, Jean Jacques ^b   Andersson, Karl Erik ^c   De Wachter, Stefan ^d   Dmochowski, Roger R ^e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

afferent convergence; colon bladder co morbidity; cross organ sensitization; neurogenic inflammation

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CAPSAICIN; ESTROGEN; NEUROKININ A; RESINIFERATOXIN; SUBSTANCE P;

BLADDER CAPACITY; BLADDER FUNCTION; CLINICAL STUDY; COMORBIDITY; CONSTIPATION; DISEASE ASSOCIATION; FECES INCONTINENCE; HUMAN; INTESTINE FUNCTION; IRRITABLE COLON; LARGE INTESTINE; NERVE TRACT; NEUROGENIC INFLAMMATION; NONHUMAN; PATIENT CARE; PHYSIOLOGY; REVIEW; SACRAL NERVE STIMULATION; STRESS INCONTINENCE; URINE INCONTINENCE; URODYNAMICS;

ANIMALS; COLON; COLONIC DISEASES; COMORBIDITY; DISEASE MODELS, ANIMAL; EVIDENCE-BASED MEDICINE; HUMANS; REFLEX; URINARY BLADDER; URINARY BLADDER DISEASES;

EID: 84859101091     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21228     Document Type: Review

References (73)

1. De Wachter S, Wyndaele JJ,. Impact of rectal distention on the results of evaluations of lower urinary tract sensation. J Urol 2003; 169: 1392-6.
2. De Wachter S, de Jong A, Van Dyck J, et al. Interaction of filling related sensation between anorectum and lower urinary tract and its impact on the sequence of their evacuation. A study in healthy volunteers. Neurourol Urodyn 2007; 26: 481-5.
3. Burgers R, Liem O, Canon S, et al. Effect of rectal distention on lower urinary tract function in children. J Urol 2010; 184: 1680-5.
4. Panayi DC, Khullar V, Digesu GA, et al. Rectal distension: The effect on bladder function. Neurourol Urodyn 2011; 30: 344-7.
5. Klingele CJ, Lightner DJ, Fletcher JG, et al. Dysfunctional urinary voiding in women with functional defecatory disorders. Neurogastroenterol Motil 2010; 22: 1094-e284.
6. Wyndaele M, De Winter BY, Pelckmans P, et al. Lower bowel function in urinary incontinent women, urinary continent women and in controls. Neurourol Urodyn 2011; 30: 138-43.
7. Khullar V, Damiano R, Toozs-Hobson P, et al. Prevalence of faecal incontinence among women with urinary incontinence. Br J Obstet Gynaecol 1998; 105: 1211-3.
8. Soligo M, Salvatore S, Milani R, et al. Double incontinence in urogynecologic practice: A new insight. Am J Obstet Gynecol 2003; 189: 438-43.
9. Manning J, Eyers AA, Korda A, et al. Is there an association between fecal incontinence and lower urinary dysfunction ? Dis Colon Rectum 2001; 44: 790-8.
10. Wyndaele JJ, Goldfischer ER, Morrow JD, et al. Effects of flexible-dose fesoterodine on overactive bladder symptoms and treatment satisfaction: An open-label study. Int J Clin Pract 2009; 63: 560-7.
11. De Looze D, Van Laere M, De Muynck M, et al. Constipation and other chronic gastrointestinal problems in spinal cord injury patients. Spinal Cord 1998; 36: 63-6.
12. Johnson DK, Balmaseda MT,. Pseudomembranous colitis in spinal cord injury. Arch Phys Med Rehabil 1985; 66: 394-6.
13. Chen JL, Kuo HC,. Long-term outcomes of augmentation enterocystoplasty with an ileal segment in patients with spinal cord injury. J Formos Med Assoc 2009; 108: 475-80.
14. Monga AK, Marrero JM, Stanton SL, et al. Is there an irritable bladder in the irritable bowel syndrome ? Br J Obstet Gynaecol 1997; 104: 1409-12.
15. Francis CY, Duffy JN, Whorwell PJ, et al. High prevalence of irritable bowel syndrome in patients attending urological outpatient departments. Dig Dis Sci 1997; 42: 404-7.
16. Alagiri M, Chottiner S, Ratner V, et al. Interstitial cystitis: Unexplained associations with other chronic disease and pain syndromes. Urology 1997; 49: 52-7.
17. Coyne KS, Cash B, Kopp Z, et al. The prevalence of chronic constipation and faecal incontinence among men and women with symptoms of overactive bladder. BJU Int 2011; 107: 254-61.
18. Manning J, Korda A, Benness C, et al. The association of obstructive defecation, lower urinary tract dysfunction and the benign joint hypermobility syndrome: A case-control study. Int Urogynecol J Pelvic Floor Dysfunct 2003; 14: 128-32.
19. Ng SC, Chen YC, Lin LY, et al. Anorectal dysfunction in women with urinary incontinence or lower urinary tract symptoms. Int J Gynaecol Obstet 2002; 77: 139-45.
20. Talley NJ, Lasch KL, Baum CL,. A gap in our understanding: Chronic constipation and its comorbid conditions. Clin Gastroenterol Hepatol 2009; 7: 9-19.
21. Darkow T, Fontes CL, Williamson TE,. Costs associated with the management of overactive bladder and related comorbidities. Pharmacotherapy 2005; 25: 511-9.
22. Ouslander JG,. Management of overactive bladder. N Engl J Med 2004; 350: 786-99.
23. Cardozo L, Robinson D,. Special considerations in premenopausal and postmenopausal women with symptoms of overactive bladder. Urology 2002; 60: 64-71.
24. Zhang W, Song Y, He X, et al. Prevalence and risk factors of overactive bladder syndrome in Fuzhou Chinese women. Neurourol Urodyn 2006; 25: 717-21.
25. Alling ML, Lose G, Jorgensen T,. Risk factors for lower urinary tract symptoms in women 40 to 60 years of age. Obstet Gynecol 2000; 96: 446-51.
26. Leroi AM,. The role of sacral neuromodulation in double incontinence. Colorectal Dis 2011; 13: 15-8.
27. Sievert KD, Amend B, Gakis G, et al. Early sacral neuromodulation prevents urinary incontinence after complete spinal cord injury. Ann Neurol 2010; 67: 74-84.
28. Valles M, Rodriguez A, Borau A, et al. Effect of sacral anterior root stimulator on bowel dysfunction in patients with spinal cord injury. Dis Colon Rectum 2009; 52: 986-92.
29. Floyd K, McMahon SB, Morrison JF,. Inhibition of the micturition reflex by stimulation of pelvic nerve afferents from the colon [proceedings]. J Physiol 1978; 284: 39-40.
30. Floyd K, McMahon SB, Morrison JF,. Inhibitory interactions between colonic and vesical afferents in the micturition reflex of the cat. J Physiol 1982; 322: 45-52.
31. Floyd K, Hick VE, Morrison JF,. The influence of visceral mechanoreceptors on sympathetic efferent discharge in the cat. J Physiol 1982; 323: 65-75.
32. Berkley KJ,. A life of pelvic pain. Physiol Behav 2005; 86: 272-80.
33. Malykhina AP,. Neural mechanisms of pelvic organ cross-sensitization. Neuroscience 2007; 149: 660-72.
34. Brumovsky PR, Gebhart GF,. Visceral organ cross-sensitization-An integrated perspective. Auton Neurosci 2010; 153: 106-15.
35. Yamada Y, Marshall S, Specian RD, et al. A comparative analysis of two models of colitis in rats. Gastroenterology 1992; 102: 1524-34.
36. Kim HS, Berstad A,. Experimental colitis in animal models. Scand J Gastroenterol 1992; 27: 529-37.
37. Pezzone MA, Liang R, Fraser MO,. A model of neural cross-talk and irritation in the pelvis: Implications for the overlap of chronic pelvic pain disorders. Gastroenterology 2005; 128: 1953-64.
38. Ustinova EE, Fraser MO, Pezzone MA,. Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: An afferent origin of pelvic organ cross-sensitization. Am J Physiol Renal Physiol 2006; 290: F1478-F1487.
39. + currents in bladder sensory neurons. Neuroreport 2004; 15: 2601-5.
40. Malykhina AP, Qin C, Greenwood-Van MB, et al. Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: Mechanism for pelvic organ cross-talk. Neurogastroenterol Motil 2006; 18: 936-48.
41. Qin C, Malykhina AP, Akbarali HI, et al. Cross-organ sensitization of lumbosacral spinal neurons receiving urinary bladder input in rats with inflamed colon. Gastroenterology 2005; 129: 1967-78.
42. Pan XQ, Gonzalez JA, Chang S, et al. Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol 2010; 225: 262-73.
43. Ustinova EE, Gutkin DW, Pezzone MA,. Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides. Am J Physiol Renal Physiol 2007; 292: F123-F130.
44. Asfaw TS, Hypolite J, Northington GM, et al. Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization. Am J Physiol Regul Integr Comp Physiol 2011; 300: R1392-R1400.
45. Noronha R, Akbarali H, Malykhina A, et al. Changes in urinary bladder smooth muscle function in response to colonic inflammation. Am J Physiol Renal Physiol 2007; 293: F1461-F1467.
46. Lamb K, Zhong F, Gebhart GF, et al. Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways. Am J Physiol Gastrointest Liver Physiol 2006; 290: G451-G457.
47. Kanai A, Wyndaele JJ, Andersson KE, et al. Researching bladder afferents-determining the effects of beta(3)-adrenergic receptor agonists and botulinum toxin type-A. Neurourol Urodyn 2011; 30: 684-91.
48. Winnard KP, Dmitrieva N, Berkley KJ,. Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: Modulation by estrous stage and involvement of the hypogastric nerve. Am J Physiol Regul Integr Comp Physiol 2006; 291: R1592-R1601.
49. Bielefeldt K, Lamb K, Gebhart GF,. Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol 2006; 291: G658-G665.
50. Rudick CN, Chen MC, Mongiu AK, et al. Organ cross talk modulates pelvic pain. Am J Physiol Regul Integr Comp Physiol 2007; 293: R1191-R1198.
51. Brumovsky PR, Feng B, Xu L, et al. Cystitis increases colorectal afferent sensitivity in the mouse. Am J Physiol Gastrointest Liver Physiol 2009; 297: G1250-G1258.
52. Miranda A, Mickle A, Schmidt J, et al. Neonatal cystitis-induced colonic hypersensitivity in adult rats: A model of viscero-visceral convergence. Neurogastroenterol Motil 2011; 23: 683-e281.
53. Furness JB, Costa M,. The enteric nervous system. New York, USA: Churchill Livingstone; 1982.
54. Bradshaw HB, Berkley KJ,. Estrous changes in responses of rat gracile nucleus neurons to stimulation of skin and pelvic viscera. J Neurosci 2000; 20: 7722-7.
55. Johnson OL, Berkley KJ,. Estrous influences on micturition thresholds of the female rat before and after bladder inflammation. Am J Physiol Regul Integr Comp Physiol 2002; 282: R289-R294.
56. Christianson JA, Liang R, Ustinova EE, et al. Convergence of bladder and colon sensory innervation occurs at the primary afferent level. Pain 2007; 128: 235-43.
57. Ustinova EE, Fraser MO, Pezzone MA,. Cross-talk and sensitization of bladder afferent nerves. Neurourol Urodyn 2010; 29: 77-81.
58. Amir R, Devor M,. Functional cross-excitation between afferent A- and C-neurons in dorsal root ganglia. Neuroscience 2000; 95: 189-95.
59. Amir R, Michaelis M, Devor M,. Burst discharge in primary sensory neurons: Triggered by subthreshold oscillations, maintained by depolarizing afterpotentials. J Neurosci 2002; 22: 1187-98.
60. Amir R, Kocsis JD, Devor M,. Multiple interacting sites of ectopic spike electrogenesis in primary sensory neurons. J Neurosci 2005; 25: 2576-85.
61. Amir R, Devor M,. Chemically mediated cross-excitation in rat dorsal root ganglia. J Neurosci 1996; 16: 4733-41.
62. Qiao LY, Grider JR,. Up-regulation of calcitonin gene-related peptide and receptor tyrosine kinase TrkB in rat bladder afferent neurons following TNBS colitis. Exp Neurol 2007; 204: 667-79.
63. Ness TJ, Gebhart GF,. Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the rat. J Neurophysiol 1988; 60: 1419-38.
64. Rouzade-Dominguez ML, Miselis R, Valentino RJ,. Central representation of bladder and colon revealed by dual transsynaptic tracing in the rat: Substrates for pelvic visceral coordination. Eur J Neurosci 2003; 18: 3311-24.
65. Geppetti P, Nassini R, Materazzi S, et al. The concept of neurogenic inflammation. BJU Int 2008; 101: 2-6.
66. Ratcliffe P, Abernethy L, Ansari N, et al. Discovery of potent, soluble and orally active TRPV1 antagonists. Structure-activity relationships of a series of isoxazoles. Bioorg Med Chem Lett 2011; 21: 4652-7.
67. Charrua A, Cruz CD, Narayanan S, et al. GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol 2009; 181: 379-86.
68. Trevisani M, Campi B, Gatti R, et al. The influence of alpha1-adrenoreceptors on neuropeptide release from primary sensory neurons of the lower urinary tract. Eur Urol 2007; 52: 901-8.
69. Frenkl TL, Zhu H, Reiss T, et al. A multicenter, double-blind, randomized, placebo controlled trial of a neurokinin-1 receptor antagonist for overactive bladder. J Urol 2010; 184: 616-22.
70. Green SA, Alon A, Ianus J, et al. Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence. J Urol 2006; 176: 2535-40.
71. Geppetti P, Capone JG, Trevisani M, et al. CGRP and migraine: Neurogenic inflammation revisited. J Headache Pain 2005; 6: 61-70.
72. Lu B, Figini M, Emanueli C, et al. The control of microvascular permeability and blood pressure by neutral endopeptidase. Nat Med 1997; 3: 904-7.
73. Cattaruzza F, Cottrell GS, Vaksman N, et al. Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. Br J Pharmacol 2009; 156: 730-9.