Researching bladder afferents - Determining the effects of β3-adrenergic receptor agonists and botulinum toxin type-A

Neurourology and Urodynamics

Volumn 30, Issue 5, 2011, Pages 684-691

  Kanai, Anthony ^a   Wyndaele, Jean Jacques ^b   Andersson, Karl Erik ^c   Fry, Christopher ^d   Ikeda, Youko ^a   Zabbarova, Irina ^a   DeWachter, Stefan ^e  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SURREY   (United Kingdom)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

3 adrenergic receptor agonists; Bladder afferents; Botulinum toxin type A; Optical mapping

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BOTULINUM TOXIN A; DARIFENACIN; L 748 337; MUSCARINIC RECEPTOR BLOCKING AGENT; OXYBUTYNIN; UNCLASSIFIED DRUG;

BLADDER WALL; CENTRAL NERVOUS SYSTEM; DETRUSOR MUSCLE; DRUG EFFECT; DRUG MECHANISM; HUMAN; KIDNEY INTERSTITIUM; MICTURITION; MUSCLE CONTRACTION; MUSCLE RELAXATION; NONHUMAN; OVERACTIVE BLADDER; PERIPHERAL NERVE; REVIEW; SENSORY NERVE; UROTHELIUM;

ACTION POTENTIALS; ADRENERGIC BETA-3 RECEPTOR AGONISTS; AFFERENT PATHWAYS; ANIMALS; BOTULINUM TOXINS, TYPE A; HUMANS; MECHANOTRANSDUCTION, CELLULAR; RECEPTORS, ADRENERGIC, BETA-3; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; URINARY INCONTINENCE; URINATION; URODYNAMICS; UROTHELIUM;

EID: 79959839075     PISSN: 07332467     EISSN: 15206777     Source Type: Journal    
DOI: 10.1002/nau.21102     Document Type: Review

References (50)

1. Lincoln JBG. Autonomic innervation of the urinary bladder and urethra. In: Maggi CA, editor. Nervous control of the urogenital system. Vol. 3. Chur, Switzerland and Langhorne, PA: Harwood Academic Publishers; 1993. p. 33-68.
2. de Groat WC. A neurologic basis for the overactive bladder. Urology 1997;50:36.
3. Kane DD, Shott S, Hughes WF, et al. Motor pudendal nerve characterization in the female rat. Anat Rec 2002;266:21.
4. Sengupta JN, Gebhart GF. Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol 1994;71: 2046.
5. Xu L, Gebhart GF. Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents. J Neurophysiol 2008;99: 244.
6. Zagorodnyuk VP, Gibbins IL, Costa M, et al. Properties of the major classes of mechanoreceptors in the guinea pig bladder. J Physiol 2007;585:147.
7. Kanai A, Andersson KE. Bladder afferent signaling: Recent findings. J Urol 2010;183:1288.
8. Michaelis M, Habler HJ, Jaenig W. Silent afferents: A separate class of primary afferents? Clin Exp Pharmacol Physiol 1996;23:99.
9. Habler HJ, Janig W, Koltzenburg M. Receptive properties of myelinated primary afferents innervating the inflamed urinary bladder of the cat. J Neurophysiol 1993;69:395.
10. Steers WD, Ciambotti J, Etzel B, et al. Alterations in afferent pathways from the urinary bladder of the rat in response to partial urethral obstruction. J Comp Neurol 1991;310:401.
11. Cheng CL, de Groat WC. The role of capsaicin-sensitive afferent fibers in the lower urinary tract dysfunction induced by chronic spinal cord injury in rats. Exp Neurol 2004;187:445.
12. Steers WD, Mackway-Gerardi AM, Ciambotti J, et al. Alterations in neural pathways to the urinary bladder of the rat in response to streptozotocin-induced diabetes. J Auton Nerv Syst 1994;47:83.
13. Yoshimura N, de Groat WC. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation. J Neurosci 1999;19:4644.
14. Ustinova EE, Gutkin DW, Pezzone MA. Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides. Am J Physiol Renal Physiol 2007;292: F123.
15. Hou S, Duale H, Rabchevsky AG. Intraspinal sprouting of unmyelinated pelvic afferents after complete spinal cord injury is correlatedwith autonomic dysreflexia induced by visceral pain. Neuroscience 2009;159:369.
16. Araki I, Du S, Kobayashi H, et al. Roles of mechanosensitive ion channels in bladder sensory transduction and overactive bladder. Int J Urol 2008;15: 681.
17. Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes--a possible sensory mechanism? J Physiol 1997;505:503.
18. Yoshida M, Inadome A, Maeda Y, et al. Non-neuronal cholinergic system in human bladder urothelium. Urology 2006;67:425.
19. Aizawa N, Igawa Y, Nishizawa O, et al. Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment. Eur Urol 2011;59:264.
20. Cockayne DA, Dunn PM, Zhong Y, et al. P2X2 knockout mice and P2X2/P2X3 double knockoutmice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 2005;567:621.
21. Vlaskovska M, Kasakov L, Rong W, et al. P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci 2001;21: 5670.
22. Aizawa N, Igawa Y, Andersson KE, et al. Effects of intravesical instillation of ATP on rat bladder primary afferent activity and its relationship with capsaicin-sensitivity. Neurourol Urodyn 2011;30:163.
23. Smith CP, Gangitano DA, Munoz A, et al. Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury. Neurochem Int 2008;52:1068.
24. Khera M, Somogyi GT, Kiss S, et al. Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury. Neurochem Int 2004;45:987.
25. Birder LA, Barrick SR, Roppolo JR, et al. Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 2003;285:F423.
26. Sun Y, Chai TC. Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis. Am J Physiol Cell Physiol 2006;290:C27.
27. Chess-Williams R. Muscarinic receptors of the urinary bladder: Detrusor, urothelial and prejunctional. Auton Autacoid Pharmacol 2002;22:133.
28. Zarghooni S, Wunsch J, Bodenbenner M, et al. Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sci 2007;80:2308.
29. Datta SN, Roosen A, Pullen A, et al. Immunohistochemical expression of muscarinic receptors in the urothelium and suburothelium of neurogenic and idiopathic overactive human bladders, and changes with botulinum neurotoxin administration. J Urol 2010;184:2578.
30. Grol S, Essers PB, van Koeveringe GA, et al.M(3)muscarinic receptor expression on suburothelial interstitial cells. BJU Int 2009;104:398.
31. Nandigama R, Bonitz M, Papadakis T, et al. Muscarinic acetylcholine receptor subtypes expressed by mouse bladder afferent neurons. Neuroscience 2010;168:842.
32. De Laet K, De Wachter S, Wyndaele JJ. Systemic oxybutynin decreases afferent activity of the pelvic nerve of the rat: New insights into the working mechanism of antimuscarinics. Neurourol Urodyn 2006;25:156.
33. Iijima K, De Wachter S, Wyndaele JJ. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol 2007;52:842.
34. Haga N, Aikawa K, Shishido K, et al. Effect of long-term oxybutynin administration on c-Fos expression in spinal neurons: Inhibition of antimuscarinics on bladder afferents in conscious rats. Urology 2009;73:200.
35. Limberg BJ, Andersson KE, Aura Kullmann F, et al. Beta-adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Cell Tissue Res 2010;342:295.
36. Aizawa N, Igawa Y, Nishizawa O, et al. Effects of CL316,243, a beta 3-adrenoceptor agonist, and intravesical prostaglandin E2 onthe primary bladder afferent activity of the rat. Neurourol Urodyn 2010;29:771.
37. Birder LA, Apodaca G, De Groat WC, et al. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol 1998;275:F226.
38. Smith CP, Radziszewski P, Borkowski A, et al. Botulinum toxin a has antinociceptive effects in treating interstitial cystitis. Urology 2004;64:871.
39. Aoki KR, Guyer B. Botulinumtoxin type A and other botulinumtoxin serotypes: Acomparative reviewof biochemical and pharmacological actions. Eur J Neurol 2001;8:21.
40. Roosen A, Datta SN, Chowdhury RA, et al. Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment. Eur Urol 2009;55:1440.
41. Lucioni A, Bales GT, Lotan TL, et al. Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation. BJU Int 2008;101:366.
42. McCarthy CJ, Zabbarova IV, Brumovsky PR, et al. Spontaneous contractions evoke afferent nerve firing in mouse bladderswith detrusor overactivity. J Urol 2009;181:1459.
43. Fujimura T, Tamura K, Tsutsumi T, et al. Expression and possible functional role of the beta3-adrenoceptor in human and rat detrusor muscle. J Urol 1999;161:680.
44. Otsuka A, Shinbo H, Matsumoto R, et al. Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium. Naunyn Schmiedebergs Arch Pharmacol 2008;377:473.
45. Lecci A, Maggi CA. Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul Pept 2001;101:1.
46. Zeng XP, Moore KH, Burcher E. Characterization of tachykinin NK2 receptors in human urinary bladder. J Urol 1995;153:1688.
47. Sculptoreanu A, de Groat WC. Neurokinins enhance excitability in capsaicin-responsive DRG neurons. Exp Neurol 2007;205:92.
48. Sculptoreanu A, Artim DE, de Groat WC. Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons. Exp Neurol 2009;219:562.
49. Smet PJ, Jonavicius J, Marshall VR, et al. Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 1996;71:337.
50. Hanna-Mitchell AT, Beckel JM, Barbadora S, et al. Non-neuronal acetylcholine and urinary bladder urothelium. Life Sci 2007;80:2298.