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Volumn 8, Issue 4, 2012, Pages 234-242

Effects of Curcurma cotnosa Roxb. On platelet aggregation and atherosclerotic plaque development in hypercholesterolemic rabbits

Author keywords

Atherosclerosis; Curcuma comosa; Hypercholesterolemia; Platelet aggregation; Therapeutic potential

Indexed keywords

ACETYLCHOLINE; ADENOSINE DIPHOSPHATE; CHOLESTEROL; CURCUMA COMOSA EXTRACT; HYPOCHOLESTEROLEMIC AGENT; LIPID; NITROPRUSSIDE SODIUM; PLANT EXTRACT; SIMVASTATIN; UNCLASSIFIED DRUG;

EID: 84859074698     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2012.234.242     Document Type: Article
Times cited : (6)

References (52)
  • 1
    • 67649399591 scopus 로고    scopus 로고
    • Effects of cholesterol feeding periods on blood haematology and biochemistry of rabbits
    • Abdelhalim, M.A.K. and H.A. Alhadlaq, 2008. Effects of cholesterol feeding periods on blood haematology and biochemistry of rabbits. Int. J. Biol. Chem., 2: 49-53.
    • (2008) Int. J. Biol. Chem , vol.2 , pp. 49-53
    • Abdelhalim, M.A.K.1    Alhadlaq, H.A.2
  • 2
    • 0032773480 scopus 로고    scopus 로고
    • Nitric oxide synthase II (TSTOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors
    • Alfon, J., J.F. Guasch, M. Berrozpe and L. Badimon, 1999. Nitric oxide synthase II (TSTOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors. Atherosclerosis, 145: 325-331.
    • (1999) Atherosclerosis , vol.145 , pp. 325-331
    • Alfon, J.1    Guasch, J.F.2    Berrozpe, M.3    Badimon, L.4
  • 3
    • 60249083382 scopus 로고    scopus 로고
    • Redeeming measure of atorvastatin in the risk factors of cardiovascular disease
    • Anand, V Chenniappan., Uma, Saravanan and S. Kumar, 2008. Redeeming measure of atorvastatin in the risk factors of cardiovascular disease. Int. J. Pharmacol., 4: 305-309.
    • (2008) Int. J. Pharmacol , vol.4 , pp. 305-309
    • Anand, V.C.1    Uma, S.2    Kumar, S.3
  • 4
    • 0023103130 scopus 로고
    • Intracellular mechanisms in the activations of human platelets by low-density lipoproteins
    • Andrews, H.E., J.W. Aitken, D.G. Hassall, V.O. Skinner and K.R. Bruckdorfer, 1987. Intracellular mechanisms in the activations of human platelets by low-density lipoproteins. Biochem. J., 242: 559-564.
    • (1987) Biochem. J , vol.242 , pp. 559-564
    • Andrews, H.E.1    Aitken, J.W.2    Hassall, D.G.3    Skinner, V.O.4    Bruckdorfer, K.R.5
  • 5
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration
    • Antithrombotic Trialists' Collaboration, 2002. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. BMJ.,324: 71-86.
    • (2002) BMJ , vol.324 , pp. 71-86
  • 6
    • 0027738796 scopus 로고
    • Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages
    • Bernini, F., G. Didoni, G. Bonfadini, S. Bellosta and R. Fumagalli, 1993. Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. Atherosclerosis, 104: 19-26.
    • (1993) Atherosclerosis , vol.104 , pp. 19-26
    • Bernini, F.1    Didoni, G.2    Bonfadini, G.3    Bellosta, S.4    Fumagalli, R.5
  • 7
    • 0032029268 scopus 로고    scopus 로고
    • Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo
    • Bode-Boger, S.M., R.H. Boger, S. Kienke, M. Bohme, L. Phivthong-Ngam, D. Tsikas and J.C. Frolich, 1998. Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo. Cardiovasc. Res., 37: 756-764.
    • (1998) Cardiovasc Res , vol.37 , pp. 756-764
    • Bode-Boger, S.M.1    Boger, R.H.2    Kienke, S.3    Bohme, M.4    Phivthong-Ngam, L.5    Tsikas, D.6    Frolich, J.C.7
  • 8
    • 0002301506 scopus 로고
    • Quantitative investigation into the aggregation of blood platelets
    • Born, G.V.R., 1962. Quantitative investigation into the aggregation of blood platelets. J. Physiol., 162: 67-68.
    • (1962) J. Physiol , vol.162 , pp. 67-68
    • Born, G.V.R.1
  • 9
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee, 1996. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet, 348: 1329-1339.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 11
    • 40249085612 scopus 로고    scopus 로고
    • The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves
    • Chumark, P., P. Khunawat, Y. Sanvarinda, S. Phornchirasilp and N.P. Morales et al, 2008. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. J. Ethnopharmacology, 116: 439-446.
    • (2008) J. Ethnopharmacology , vol.116 , pp. 439-446
    • Chumark, P.1    Khunawat, P.2    Sanvarinda, Y.3    Phornchirasilp, S.4    Morales, N.P.5
  • 13
    • 20144375193 scopus 로고    scopus 로고
    • Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2
    • Fateh-Moghadam, S., Z. Li, S. Ersel, T. Reuter and P. Htun et al, 2005. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Arterioscler. Thromb. Vase. Biol, 25: 1299-1303.
    • (2005) Arterioscler. Thromb. Vase. Biol , vol.25 , pp. 1299-1303
    • Fateh-Moghadam, S.1    Li, Z.2    Ersel, S.3    Reuter, T.4    Htun, P.5
  • 17
    • 78649798576 scopus 로고    scopus 로고
    • Emerging evidences from the contribution of the traditional and new risk factors to the atherosclerosis pathogenesis
    • Garelnabi, M., 2010. Emerging evidences from the contribution of the traditional and new risk factors to the atherosclerosis pathogenesis. J. Med. Sci., 10: 153-161.
    • (2010) J. Med. Sci , vol.10 , pp. 153-161
    • Garelnabi, M.1
  • 18
    • 0035075438 scopus 로고    scopus 로고
    • Platelet CD40 hgand (CD40L)-subcellular localization, regulation of expression and inhibition by clopidogrel
    • Hermann, A., B.H. Rauch, M. Braun, K. Schror and A.A. Weber, 2001. Platelet CD40 hgand (CD40L)-subcellular localization, regulation of expression and inhibition by clopidogrel. Platelets, 12: 74-82.
    • (2001) Platelets , vol.12 , pp. 74-82
    • Hermann, A.1    Rauch, B.H.2    Braun, M.3    Schror, K.4    Weber, A.A.5
  • 19
    • 70349882083 scopus 로고    scopus 로고
    • Enhancement of vascular relaxation in rat aorta by phytoestrogens from Curcuma comosa Roxb
    • Intapad, S., A. Suksamrarn and P. Piyachaturawat, 2009. Enhancement of vascular relaxation in rat aorta by phytoestrogens from Curcuma comosa Roxb. Vase. Pharmacol, 51: 284-290.
    • (2009) Vase. Pharmacol , vol.51 , pp. 284-290
    • Intapad, S.1    Suksamrarn, A.2    Piyachaturawat, P.3
  • 20
    • 58649085872 scopus 로고    scopus 로고
    • Role of platelets in atherothrombosis
    • Jennings, L.K., 2009. Role of platelets in atherothrombosis. Am. J. Cardiol, 103: 4A-10A.
    • (2009) Am. J. Cardiol , vol.103
    • Jennings, L.K.1
  • 21
    • 0001447433 scopus 로고    scopus 로고
    • Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women
    • Koh, K.K., C. Cardillo, M.N. Bui, L. Hathaway and G. Csako et al., 1999. Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women. Circulation, 99: 354-360.
    • (1999) Circulation , vol.99 , pp. 354-360
    • Koh, K.K.1    Cardillo, C.2    Bui, M.N.3    Hathaway, L.4    Csako, G.5
  • 22
    • 0027537180 scopus 로고
    • UVB radiation exposes fibrinogen binding sites on platelets by activating protein kinase C via reactive oxygen species
    • Kooy, M.V.M., J.W.N. Akkerman, S. van Asbeck, L. Borghms and H.C. van Prooyen, 1993. UVB radiation exposes fibrinogen binding sites on platelets by activating protein kinase C via reactive oxygen species. Br. J. Haematol, 83: 253-258.
    • (1993) Br. J. Haematol , vol.83 , pp. 253-258
    • Kooy, M.V.M.1    Akkerman, J.W.N.2    van Asbeck, S.3    Borghms, L.4    van Prooyen, H.C.5
  • 23
    • 0031451344 scopus 로고    scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
    • Laufs, U., V. La Fata and J.K. Liao, 1997. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J. Biol. Chem., 272: 31725-31729.
    • (1997) J. Biol. Chem , vol.272 , pp. 31725-31729
    • Laufs, U.1    la Fata, V.2    Liao, J.K.3
  • 24
    • 77952967766 scopus 로고    scopus 로고
    • Cyclic nucleotides and mitogen-activated protein kinases: Regulation of simvastatin in platelet activation
    • Lee, Y.M., W.F. Chen, D.S. Chou, T. Jayakumar and S.Y. Hou et al, 2010. Cyclic nucleotides and mitogen-activated protein kinases: Regulation of simvastatin in platelet activation. J. Biomed. Sci., 17: 45-54.
    • (2010) J. Biomed. Sci , vol.17 , pp. 45-54
    • Lee, Y.M.1    Chen, W.F.2    Chou, D.S.3    Jayakumar, T.4    Hou, S.Y.5
  • 26
    • 0033542402 scopus 로고    scopus 로고
    • Mechanisms of disease: The protective effects of estrogen on the cardiovascular system
    • Mendelsohn, M.E. and R.H. Karas, 1999. Mechanisms of disease: The protective effects of estrogen on the cardiovascular system. N. Eng. J. Med., 340: 1801-1811.
    • (1999) N. Eng. J. Med , vol.340 , pp. 1801-1811
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 27
    • 0028200447 scopus 로고
    • Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions
    • Miller, M.E., G.M. Dores, S.L. Thorpe and W.L. Akerley, 1994. Paradoxical influence of estrogenic hormones on platelet-endothelial cell interactions. Thromb. Res., 74: 577-594.
    • (1994) Thromb. Res , vol.74 , pp. 577-594
    • Miller, M.E.1    Dores, G.M.2    Thorpe, S.L.3    Akerley, W.L.4
  • 28
    • 77957126077 scopus 로고
    • Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women
    • Miller, V.T., J. LaRosa, V. Barnabei, C. Kessler and G. Levin et al., 1995. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA, 273: 199-208.
    • (1995) JAMA , vol.273 , pp. 199-208
    • Miller, V.T.1    Larosa, J.2    Barnabei, V.3    Kessler, C.4    Levin, G.5
  • 29
    • 0031595187 scopus 로고    scopus 로고
    • Effect of 17-beta estradiol on inhibition of platelet aggregation in vitro is mediated by an increase in NO synthesis
    • Nakano, Y., T. Oshima, H. Matsuura, G. Kajiyama and M. Kambe, 1998. Effect of 17-beta estradiol on inhibition of platelet aggregation in vitro is mediated by an increase in NO synthesis. Arterioscler. Thromb. Vase. Biol, 18: 961-967.
    • (1998) Arterioscler. Thromb. Vase. Biol , vol.18 , pp. 961-967
    • Nakano, Y.1    Oshima, T.2    Matsuura, H.3    Kajiyama, G.4    Kambe, M.5
  • 31
    • 84858062814 scopus 로고    scopus 로고
    • Cholesterol-lowering and artherosclerosis inhibitory effect of Sibu olive in cholesterol fed-rabbit
    • In Press
    • Nurulhuda, M.H., A. Azlan, A. Ismail, Z. Amom and F.H. Shakirin, 2012. Cholesterol-lowering and artherosclerosis inhibitory effect of Sibu olive in cholesterol fed-rabbit. Asian. J. Biochem., Vol. 7, (In Press).
    • (2012) Asian. J. Biochem , vol.7
    • Nurulhuda, M.H.1    Azlan, A.2    Ismail, A.3    Amom, Z.4    Shakirin, F.H.5
  • 32
    • 77955575890 scopus 로고    scopus 로고
    • The overview of the chemistry, health benefits and the potential threats associated with prolonged exposure to dietary soy isoflavones
    • Ogbuewu, LP., A.A. Omede, O.K. Chukwuka, O.O.M. Iheshmlor and M.C. Uchegbu et al, 2010. The overview of the chemistry, health benefits and the potential threats associated with prolonged exposure to dietary soy isoflavones. Int. J. Agric. Res., 5: 1-16.
    • (2010) Int. J. Agric. Res , vol.5 , pp. 1-16
    • Ogbuewu, L.P.1    Omede, A.A.2    Chukwuka, O.K.3    Iheshmlor, O.O.M.4    Uchegbu, M.C.5
  • 34
    • 0347043610 scopus 로고    scopus 로고
    • Platelet factor 4 localization in carotid atherosclerotic plaques: Correlation with clinical parameters
    • Pitsilos, S., J. Hunt, E.R. Mohler, A.M. Prabhakar and M. Ponczx et al, 2003. Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thromb. Haemost.,90: 1112-1120.
    • (2003) Thromb. Haemost , vol.90 , pp. 1112-1120
    • Pitsilos, S.1    Hunt, J.2    Mohler, E.R.3    Prabhakar, A.M.4    Ponczx, M.5
  • 35
    • 0033057056 scopus 로고    scopus 로고
    • Reduction of plasma cholesterol by Curcuma comosa extract in hypercholesterolaemic hamsters
    • Piyachaturawat, P., J. Charoenpiboonsin, C. Toskulkao and A. Suksamrarn, 1999. Reduction of plasma cholesterol by Curcuma comosa extract in hypercholesterolaemic hamsters. J. EthnopharmacoL, 66: 199-204.
    • (1999) J. EthnopharmacoL , vol.66 , pp. 199-204
    • Piyachaturawat, P.1    Charoenpiboonsin, J.2    Toskulkao, C.3    Suksamrarn, A.4
  • 36
    • 0037165492 scopus 로고    scopus 로고
    • Evaluation of the acute and subacute toxicity of a choleretic phloracetophenone in experimental animals
    • Piyachaturawat, P., C. Tubtim, A. Chuncharunee, P. Komaratat and A. Suksamrarn, 2002a. Evaluation of the acute and subacute toxicity of a choleretic phloracetophenone in experimental animals. Toxicol. Lett, 129: 123-132.
    • (2002) Toxicol. Lett , vol.129 , pp. 123-132
    • Piyachaturawat, P.1    Tubtim, C.2    Chuncharunee, A.3    Komaratat, P.4    Suksamrarn, A.5
  • 38
    • 79960402741 scopus 로고    scopus 로고
    • Protective effect of leaf extract of Trichilia connaroides on hypercholesterolemia induced oxidative stress
    • Prasanna, G. S. and A. Purnima, 2011. Protective effect of leaf extract of Trichilia connaroides on hypercholesterolemia induced oxidative stress. Int. J. Pharmacol, 7: 106-112.
    • (2011) Int. J. Pharmacol , vol.7 , pp. 106-112
    • Prasanna, G.S.1    Purnima, A.2
  • 39
  • 40
    • 0032572043 scopus 로고    scopus 로고
    • Antiatherothrombotic properties of statins: Implications for cardiovascular event reduction
    • Rosenson, R.S. and C.C. Tangney, 1998. Antiatherothrombotic properties of statins: Implications for cardiovascular event reduction. JAMA, 279: 1643-1650.
    • (1998) JAMA , vol.279 , pp. 1643-1650
    • Rosenson, R.S.1    Tangney, C.C.2
  • 41
    • 84859030972 scopus 로고    scopus 로고
    • From evolution of platelets to their role in heart attacks
    • Saeed, S.A., M.Z.S. Urfy, F.W.A. Khimani and S.O. Saeed, 2004. From evolution of platelets to their role in heart attacks. J. Med. Sci., 4: 47-51.
    • (2004) J. Med. Sci , vol.4 , pp. 47-51
    • Saeed, S.A.1    Urfy, M.Z.S.2    Khimani, F.W.A.3    Saeed, S.O.4
  • 42
    • 0028881306 scopus 로고
    • Expression of constitutive endothelial nitric oxide synthase in human blood platelets
    • Sase, K. and T. Michel, 1995. Expression of constitutive endothelial nitric oxide synthase in human blood platelets. Life Sci., 57: 2049-2055.
    • (1995) Life Sci , vol.57 , pp. 2049-2055
    • Sase, K.1    Michel, T.2
  • 43
    • 41149097506 scopus 로고    scopus 로고
    • Effect of atorvastatin on paraoxonase activity in-patients with hyperlipidemia
    • Shetty, J.K., M. Prakash, S. Tripathy, M. Verma and P. Vikram, 2008. Effect of atorvastatin on paraoxonase activity in-patients with hyperlipidemia. Asian J. Biochem., 3: 139-142.
    • (2008) Asian J. Biochem , vol.3 , pp. 139-142
    • Shetty, J.K.1    Prakash, M.2    Tripathy, S.3    Verma, M.4    Vikram, P.5
  • 44
    • 33847071264 scopus 로고    scopus 로고
    • Suppression by Curcuma comosa Roxb. Of pro-inflammatory cytokine secretion in phorbol-12-myristate-l 3-acetate stimulated human mononuclear cells
    • Sodsai, A., P. Piyachaturawat, S. Sophasan, A. Suksamrarn and M. Vongsakul, 2007. Suppression by Curcuma comosa Roxb. Of pro-inflammatory cytokine secretion in phorbol-12-myristate-l 3-acetate stimulated human mononuclear cells. Int. Immunopharmacol., 7: 524-533.
    • (2007) Int. Immunopharmacol , vol.7 , pp. 524-533
    • Sodsai, A.1    Piyachaturawat, P.2    Sophasan, S.3    Suksamrarn, A.4    Vongsakul, M.5
  • 46
    • 33750372559 scopus 로고    scopus 로고
    • Protection of endothelial function: Targets for nutritional and pharmacological interventions
    • Sudano, I., L.E. Spieker, F. Hermann, A. Flammer and R. Corti et al., 2006. Protection of endothelial function: Targets for nutritional and pharmacological interventions. J. Cardiovasc. Pharmacol, 47: S136-S150.
    • (2006) J. Cardiovasc. Pharmacol , vol.47
    • Sudano, I.1    Spieker, L.E.2    Hermann, F.3    Flammer, A.4    Corti, R.5
  • 47
    • 41049092691 scopus 로고    scopus 로고
    • Lipid management to reduce cardiovascular risk: A new strategy is required
    • Superko, H.R. and S. King, 2008. Lipid management to reduce cardiovascular risk: A new strategy is required. Circulation, 117: 560-568.
    • (2008) Circulation , vol.117 , pp. 560-568
    • Superko, H.R.1    King, S.2
  • 48
    • 0037097809 scopus 로고    scopus 로고
    • Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia
    • Theilmeier, G., C. Michiels, E. Spaepen, I. Vreys and D. Collen et al, 2002. Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia. Blood, 99: 4486-4493.
    • (2002) Blood , vol.99 , pp. 4486-4493
    • Theilmeier, G.1    Michiels, C.2    Spaepen, E.3    Vreys, I.4    Collen, D.5
  • 49
    • 0035826856 scopus 로고    scopus 로고
    • Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V and factor XIII and by enhancing factor Va inactivation
    • Undas, A., K.E. Brummel, J. Musial, K.G. Mann and A. Szczeklik, 2001. Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V and factor XIII and by enhancing factor Va inactivation. Circulation, 103: 2248-2253.
    • (2001) Circulation , vol.103 , pp. 2248-2253
    • Undas, A.1    Brummel, K.E.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 50
    • 0028049273 scopus 로고
    • LDLs increase the exposure of fibrinogen binding sites on platelets and secretion of dense granules
    • Van Wilhgen, G., G. Gorter and J.W. Akkerman, 1994. LDLs increase the exposure of fibrinogen binding sites on platelets and secretion of dense granules. Arterioscler. Thromb., 14: 41-46.
    • (1994) Arterioscler. Thromb , vol.14 , pp. 41-46
    • van Wilhgen, G.1    Gorter, G.2    Akkerman, J.W.3
  • 51
    • 33846990867 scopus 로고    scopus 로고
    • Chronic dysfunction in spontaneously hypertensive rats: Involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity
    • Vera, R, M. Sanchez, M. Galisteo, I.C. Villar and R. Jimenez et al, 2007. Chronic dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity. Clin Sci.,112: 183-191.
    • (2007) Clin Sci , vol.112 , pp. 183-191
    • Vera, R.1    Sanchez, M.2    Galisteo, M.3    Villar, I.C.4    Jimenez, R.5
  • 52
    • 0031051122 scopus 로고    scopus 로고
    • Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans
    • Wolf, A., C. Zalpour, G. Theilmeier, B.Y. Wang and A. Ma et al, 1997. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J. Am. Coll. Cardiol, 29: 479-485.
    • (1997) J. Am. Coll. Cardiol , vol.29 , pp. 479-485
    • Wolf, A.1    Zalpour, C.2    Theilmeier, G.3    Wang, B.Y.4    Ma, A.5


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